Zobrazeno 1 - 10
of 11
pro vyhledávání: '"N. M. Clayton"'
Autor:
J. W. Clitherow, R. Stables, N. M. Clayton, C. J. Grinham, A. McLAREN, A. A. McCOLM, C. J. Campbell, M. A. Trevethick
Publikováno v:
Alimentary Pharmacology & Therapeutics. 7:237-246
SUMMARY Ranitidine bismuth citrate is a novel compound formed from ranitidine and a bismuth citrate complex. In conscious dogs, ranitidine bismuth citrate had similar activity to ranitidine hydrochloride as an inhibitor of histamine-induced gastric a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1af5c91d8eac516686e44276401ecc
https://doi.org/10.1111/j.1365-2036.1993.tb00094.x
https://doi.org/10.1111/j.1365-2036.1993.tb00094.x
Publikováno v:
Alimentary Pharmacology & Therapeutics. 10:339-345
Background : The role of acid in the pathogenesis of indomethacin-induced ulcers of the rat gastric antrum was studied by comparing the effects of pretreating animals with both long-acting (loxtidine, AH22216) and short-acting (ranitidine and cimetid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce458d7203e1c7e1d0bcff0895cbca43
https://doi.org/10.1111/j.0953-0673.1996.00339.x
https://doi.org/10.1111/j.0953-0673.1996.00339.x
Publikováno v:
Gut. 34:156-160
The potential involvement of neutrophils in the pathogenesis of indomethacin induced ulceration of the gastric antrum in the re-fed rat was studied. Indomethacin was associated with a time dependent increase in the extent and severity of ulceration,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f109458e7ea4a144bbd9faab1b0ea66f
https://doi.org/10.1136/gut.34.2.156
https://doi.org/10.1136/gut.34.2.156
Autor:
Patrick P.A. Humphrey, C. Bountra, Jeremy D. Gale, V J Barrett, R Sargent, D Cambridge, A A Hunt, M P Maxwell, A. D. Butler, N. M. Clayton
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 11(3)
The purpose of this study was to investigate the pharmacological properties of the novel, selective 5-HT3 receptor antagonist, alosetron, and its effects on transit time in both the normal and perturbed small intestine of the rat. Alosetron concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f63d4e484667e468e39a63e617817e4
http://ora.ox.ac.uk/objects/uuid:4115c8b7-6b2d-4f33-866b-2ada6b6bad36
http://ora.ox.ac.uk/objects/uuid:4115c8b7-6b2d-4f33-866b-2ada6b6bad36
Autor:
N. M. Clayton, Jeremy D. Gale
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 8(1)
Cisapride and metoclopramide are used clinically in the treatment of gastro-oesophageal reflux disease and also in a variety of motility disorders of the gastrointestinal tract. Their prokinetic effect is thought to be due to the augmentation of acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c128e958b4f662b6d393d85ad944af86
https://pubmed.ncbi.nlm.nih.gov/8697180
https://pubmed.ncbi.nlm.nih.gov/8697180
Autor:
M. A. Trevethick, P. Strong, A. K. Bahl, Ian G. Oakley, D.P. Martin, N. M. Clayton, Jill Coates
Publikováno v:
British journal of pharmacology. 117(3)
1. This paper compares the activity of a range of agonists as stimulants of the beta 3-adrenoceptor in rat isolated oesophagus with their ability to afford protection against indomethacin-induced gastric damage in the conscious rat. 2. The beta 3-adr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7127b5c3dd7c73331dc487eea122ef76
https://pubmed.ncbi.nlm.nih.gov/8821552
https://pubmed.ncbi.nlm.nih.gov/8821552
Publikováno v:
Agents and actions. 43(1-2)
We have previously suggested (Trevethick et al., Gut 34, 156-160) that indomethacin-induced ulceration of the rat gastric antrum may be a neutrophil-dependent process. Accordingly, in this study we have used an anti-neutrophil serum (ANS) to investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0dc4b75db477bf7738a3118412fb04
https://pubmed.ncbi.nlm.nih.gov/7741039
https://pubmed.ncbi.nlm.nih.gov/7741039
Publikováno v:
Agents and actions. 41(3-4)
The potential involvement of leukotrienes in the pathogenesis of indomethacin-induced ulceration of the rat gastric antrum has been studied. Pretreatment with the leukotriene biosynthesis inhibitor, MK886 (30 mg/kg p.o.), inhibited the increases in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abaaeb52ce9a56d939cf5093655b923
https://pubmed.ncbi.nlm.nih.gov/7942326
https://pubmed.ncbi.nlm.nih.gov/7942326
Autor:
K T, Bunce, N M, Clayton, R A, Coleman, E W, Collington, H, Finch, J M, Humphray, P P, Humphrey, J J, Reeves, R L, Sheldrick, R, Stables
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1854871fb1ce8d8d8932dc298c766ffc
https://pubmed.ncbi.nlm.nih.gov/1825574
https://pubmed.ncbi.nlm.nih.gov/1825574
Publikováno v:
Agents and Actions. 41:C226-C227
Indomethacin-induced ulceration of the rat gastric antrum is paralleled by an increase in blood neutrophil numbers and of neutrophil infiltration into the antrum. Thus, in this study, neutrophil depletion has been employed to study the potential role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::194a213ab7ef999e557423904c970dd5
https://doi.org/10.1007/bf01987647
https://doi.org/10.1007/bf01987647