Zobrazeno 1 - 10
of 67
pro vyhledávání: '"N. M. Blackett"'
Publikováno v:
Cytokine. 10:49-54
Interleukin 3 (IL-3) and stem cell factor (SCF) are both important regulators of early haemopoietic cell development. Here, we have compared their effects or the kinetics of erythroid burst formation by BFU-E in normal adult bone marrow. We grew the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a102838e56e5dcaa14497b3b20103c8
https://doi.org/10.1006/cyto.1997.0256
https://doi.org/10.1006/cyto.1997.0256
Autor:
N M Blackett, M Y Gordon
Publikováno v:
Cell Transplantation, Vol 7 (1998)
The practice of hematopoietic stem cell transplantation to rescue patients from the myeloablative effects of chemo- or radiotherapy, or to replace defective hematopoiesis, is based on the assumption that hematopoietic stem cells in the graft have suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f8386e92a2c2dc3f8f43902d90472f
https://doaj.org/article/5a7cbf35729b4daa8df045f792211a01
https://doaj.org/article/5a7cbf35729b4daa8df045f792211a01
Autor:
N M, Blackett, M Y, Gordon
Publikováno v:
British journal of haematology. 92(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1e6bfdc713449b0349ec59af97f1d9c
https://pubmed.ncbi.nlm.nih.gov/9136981
https://pubmed.ncbi.nlm.nih.gov/9136981
Publikováno v:
Leukemia. 9(7)
One of the controversies surrounding the repopulating capacities of haemopoietic stem cells is whether or not the same or different populations are responsible for short-term and long-term repopulation after transplantation. To address this question,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51a98f3c846bcdce6e5af255499bb0a5
https://pubmed.ncbi.nlm.nih.gov/7630201
https://pubmed.ncbi.nlm.nih.gov/7630201
Autor:
M Y, Gordon, N M, Blackett
Publikováno v:
Bone marrow transplantation. 15(5)
Theoretically, a single pluripotent haemopoietic stem cell should be able to reconstitute haemopoiesis following transplantation. However, clinical and experimental observations demonstrate that it is necessary to transplant numerous stem cells to ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c06e92730f85d821fc5b5b2c905871d
https://pubmed.ncbi.nlm.nih.gov/7670392
https://pubmed.ncbi.nlm.nih.gov/7670392
Publikováno v:
British journal of haematology. 88(2)
Summary. Video-recordings of whole normal bone marrow granulocyte-macrophage colony (CFU-GM) cultures were made after 7, 14 and 21 d. Retrospective viewing of the tapes allowed the relationships to each other of the colonies scored on the three diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df45bba98e0648773972719e391a6841
https://pubmed.ncbi.nlm.nih.gov/7803302
https://pubmed.ncbi.nlm.nih.gov/7803302
Autor:
M Y, Gordon, N M, Blackett
Publikováno v:
Leukemia. 8(6)
In summary, we propose that the haemopoietic system consists of a hierarchy of clonogenic stem and progenitor cells and that the stochastic effect is superimposed upon these compartments. This means that (i) considerable heterogeneity can exist withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afea50c5cac563c147bdf46a7efd409c
https://pubmed.ncbi.nlm.nih.gov/8207981
https://pubmed.ncbi.nlm.nih.gov/8207981
Autor:
N. M. Blackett, T. A. Boarder
Publikováno v:
Cell Proliferation. 9:589-596
High concentrations of tritiated thymidine and cytosine arabinoside (Ara-C) have been used to selectively kill cells in the crypts of Lieberkuhn that are synthesizing DNA. The effect of these agents on the number of regenerating microcolonies seen 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da69da8bed45f95796b0dc8ed821f24
https://doi.org/10.1111/j.1365-2184.1976.tb01308.x
https://doi.org/10.1111/j.1365-2184.1976.tb01308.x
Autor:
N. M. Blackett
Publikováno v:
Cell Proliferation. 20:393-402
Substantial support has been obtained for the stochastic model for stem cell differentiation first proposed by Till, McCulloch & Siminovitch (1964), over 20 years ago. By adding a cell maturation pathway, it is possible to predict (by computer simula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ffa32ab779fe04f7be890bad9a6283
https://doi.org/10.1111/j.1365-2184.1987.tb01324.x
https://doi.org/10.1111/j.1365-2184.1987.tb01324.x
Publikováno v:
Cell Proliferation. 11:543-553
It is known that pretreatment of mice with bacterial endotoxin and certain stathmokinetic agents between 1 and 3 days prior to exposure to ioninzing radiation reduce radiation lethality. In this communication it is shown that pretreatment with cytosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d1fc50a4846bcdd63c140f672c3ae7
https://doi.org/10.1111/j.1365-2184.1978.tb00826.x
https://doi.org/10.1111/j.1365-2184.1978.tb00826.x