Zobrazeno 1 - 10
of 44
pro vyhledávání: '"N. Lynskey"'
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A Streptococcus (GAS), a lethal human pathogen currently associated with an unprecedented surge
Externí odkaz:
https://doaj.org/article/062aa1ee6b4045769e419927d7f794d4
Autor:
Matthew K. Siggins, Nicola N. Lynskey, Lucy E. Lamb, Louise A. Johnson, Kristin K. Huse, Max Pearson, Suneale Banerji, Claire E. Turner, Kevin Woollard, David G. Jackson, Shiranee Sriskandan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Pathogenic agents can spread from an initial to a secondary site via the lymphatics. Here, using a mouse model of infection, the authors show that S. pyogenes readily transit through sequential lymph nodes within efferent lymphatics to reach the bloo
Externí odkaz:
https://doaj.org/article/82442a72732d4568ad2c06ae269341a8
Autor:
L. E. Lamb, M. K. Siggins, C. Scudamore, W. Macdonald, C. E. Turner, N. N. Lynskey, L. K. K. Tan, S. Sriskandan
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1074-1084 (2018)
Invasive group A Streptococcus (iGAS) is frequently associated with emm1 isolates, with an attendant mortality of around 20%. Cases occasionally arise in previously healthy individuals with a history of upper respiratory tract infection, soft tissue
Externí odkaz:
https://doaj.org/article/35ff6adb318f472c9c38b92372677756
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The orphan regulator RocA plays a critical role in the colonization and pathogenesis of the obligate human pathogen group A Streptococcus. Despite multiple lines of evidence supporting a role for RocA as an auxiliary regulator of the control
Externí odkaz:
https://doaj.org/article/3b252973b25c4b33b4e9c9a6e7a86e3d
Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group AStreptococcus(GAS), a lethal human pathogen currently associated with an unprecedented surge of infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959e9bab5174747b9af766057b5a2a96
https://doi.org/10.1101/2023.04.10.536284
https://doi.org/10.1101/2023.04.10.536284
Autor:
F. Diaz-Toro, F. Petermann-Rocha, N. Lynskey, G. Nazar, I. Cigarroa, C. Troncoso, Y. Concha-Cisternas, A.M. Leiva-Ordoñez, M.A. Martinez-Sanguinetti, S. Parra-Soto, C. Celis-Morales
Publikováno v:
Journal of Frailty & Aging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a857d4ae80fe3b5d14dc95deb36f2332
https://doi.org/10.14283/jfa.2023.2
https://doi.org/10.14283/jfa.2023.2
Autor:
Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006493 (2017)
The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays a vital role in opsonization of bact
Externí odkaz:
https://doaj.org/article/7031e2a0cadc406fa19911befda17da0
Autor:
Michael R. Wessels, James J. Chou, Ian J Lichtenstein, Jorge J. Velarde, Nicola N Lynskey, Alessandro Piai
Publikováno v:
J Bacteriol
The emergence and continued dominance of a Streptococcus pyogenes (group A Streptococcus, GAS) M1T1 clonal group is temporally correlated with acquisition of genomic sequences that confer high level expression of cotoxins streptolysin O (SLO) and NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d271343a94b68714c85e9a3d2c863b
https://doi.org/10.1128/jb.00366-21
https://doi.org/10.1128/jb.00366-21
Autor:
Nicola N Lynskey, Suneale Banerji, Louise A Johnson, Kayla A Holder, Mark Reglinski, Peter A C Wing, David Rigby, David G Jackson, Shiranee Sriskandan
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005137 (2015)
The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a predilection to induce pathology in the lymphatic system and draining lymph nodes, however the underl
Externí odkaz:
https://doaj.org/article/53dd3fe8d8ca4781884062489bb9ec8c
Publikováno v:
Davies, F J, Olme, C, Lynskey, N N, Turner, C E & Sriskandan, S 2019, ' Streptococcal superantigen-induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death and reduced immunoglobulin release ', Clinical and Experimental Immunology, vol. 197, no. 1, pp. 83-94 . https://doi.org/10.1111/cei.13282
Clinical and Experimental Immunology
Clinical and Experimental Immunology
BackgroundStreptococcal pyrogenic exotoxin (SPE)A expression is epidemiologically linked to streptococcal tonsillo-pharyngitis and outbreaks of scarlet fever, although the mechanisms by which superantigens confer advantageStreptococcus pyogenesare un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570e3963c7e9da7d61e9ea3ece5da5cc
https://doi.org/10.1111/cei.13282
https://doi.org/10.1111/cei.13282