Zobrazeno 1 - 10
of 43
pro vyhledávání: '"N. Loftus"'
Autor:
R. Griffin, E.E. Psarelli, T.F. Cox, M. Khedr, A.M. Milan, A.S. Davison, A.T. Hughes, J.L. Usher, S. Taylor, N. Loftus, A. Daroszewska, E. West, A. Jones, M. Briggs, M. Fisher, M. McCormick, S. Judd, S. Vinjamuri, N. Sireau, J.P. Dillon, J.M. Devine, G. Hughes, J. Harrold, G.J. Barton, J.C. Jarvis, J.A. Gallagher, L.R. Ranganath
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1620-1628 (2018)
Alkaptonuria is a rare genetic disorder characterized by a high level of circulating (and urine) homogentisic acid (HGA), which contributes to ochronosis when it is deposited in connective tissue as a pigmented polymer. In an observational study carr
Externí odkaz:
https://doaj.org/article/247e76b7f67246bcbb8301147532802f
Autor:
Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionUltraviolet (UV) light is a known trigger of both cutaneous and systemic disease manifestations in lupus patients. Lupus skin has elevated expression of type I interferons (IFNs) that promote increased keratinocyte (KC) death after UV exp
Externí odkaz:
https://doaj.org/article/2688932f602c4078829249e84a14bb01
Autor:
Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, J. Michelle Kahlenberg
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components in murine models of lupus has been shown to reduce the severity of disease. Interleukin-1
Externí odkaz:
https://doaj.org/article/aa064b19d56a431ba58940d74183f8e1
Akademický článek
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Publikováno v:
GA – 70th Annual Meeting 2022.
Autor:
Joshua A. Sommers, Lorin N. Loftus, Martin P. Jones, Rebecca A. Lee, Caitlin E. Haren, Adaira J. Dumm, Robert M. Brosh
Publikováno v:
Journal of Biological Chemistry. 299:102980
Publikováno v:
Neuroscience Applied. 1:100024
Autor:
Andrew S. Davison, Sobhan Vinjamuri, S Judd, Anna M. Milan, Elizabeth West, Andrew T. Hughes, G. Hughes, J.P. Dillon, R Griffin, JM Devine, Nicolas Sireau, Jonathan C. Jarvis, N Loftus, A Jones, M McCormick, Lakshminarayan R. Ranganath, Anna Daroszewska, Sophie Taylor, Milad Khedr, James A. Gallagher, JL Usher, Michael Fisher, Joanne A. Harrold, M. C. Briggs, Trevor Cox, Eftychia E. Psarelli, Gabor Barton
Publikováno v:
Data in Brief, Vol 20, Iss, Pp 1620-1628 (2018)
Data in Brief
Data in Brief
Alkaptonuria is a rare genetic disorder characterized by a high level of circulating (and urine) homogentisic acid (HGA), which contributes to ochronosis when it is deposited in connective tissue as a pigmented polymer. In an observational study carr
Autor:
G. Hughes, JM Devine, S Judd, Anna M. Milan, Nicolas Sireau, N Loftus, James A. Gallagher, Milad Khedr, Trevor Cox, Lakshminarayan R. Ranganath, Joanne A. Harrold, Elizabeth West, Andrew S. Davison, JL Usher, J.P. Dillon, Jonathan C. Jarvis, A Jones, R Griffin, M. C. Briggs, Michael J. Fisher, Eftychia E. Psarelli, Gabor Barton, Sobhan Vinjamuri, Andrew T. Hughes, M McCormick, Anna Daroszewska, Sophie Taylor
Publikováno v:
Molecular genetics and metabolism
QUESTION: Does Nitisinone prevent the clinical progression of the Alkaptonuria? FINDINGS: In this observational study on 39 patients, 2 mg of daily nitisinone inhibited ochronosis and significantly slowed the progression of AKU over a three-year peri
Akademický článek
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