Zobrazeno 1 - 10
of 324
pro vyhledávání: '"N. Le Novère"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 14, Iss C, Pp 363-370 (2016)
Recent growth in annual new therapeutic entity (NTE) approvals by the U.S. Food and Drug Administration (FDA) suggests a positive trend in current research and development (R&D) output. Prior to this, the cost of each NTE was considered to be rising
Externí odkaz:
https://doaj.org/article/f7d4b91f21ee4dd49b77e7eaf81fd5f9
Publikováno v:
Pathology & Oncology Research. 25:1269-1277
Large investments by pharmaceutical companies in the development of new antineoplastic drugs have not been resulting in adequate advances of new therapies. Despite the introduction of new methods, technologies, translational medicine and bioinformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd183814069d39327980c80570f466a
https://doi.org/10.1007/s12253-018-0467-8
https://doi.org/10.1007/s12253-018-0467-8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 14, Iss C, Pp 363-370 (2016)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Recent growth in annual new therapeutic entity (NTE) approvals by the U.S. Food and Drug Administration (FDA) suggests a positive trend in current research and development (R&D) output. Prior to this, the cost of each NTE was considered to be rising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527669d3878aca0d51a837e3de7acb76
http://www.sciencedirect.com/science/article/pii/S2001037016300435
http://www.sciencedirect.com/science/article/pii/S2001037016300435
Autor:
R Kaye, Charlotte Kloft, Toni Giorgino, Ron J. Keizer, Joost N. Kok, Andrew C. Hooker, Lutz Harnisch, C Franklin, Lorenzo Pasotti, Pierre Grenon, D Edwards, C Sarr, Mats O. Karlsson, Maciej J. Swat, Kajsa Harling, Stuart L. Moodie, Nadia Terranova, Phylinda L. S. Chan, Henrik Bjugård Nyberg, Elodie L. Plan, N Le Novère, Marc Lavielle, J Chard, Camille Laibe, Emmanuelle Comets, Mike K. Smith, Enrica Mezzalana, G Lestini, Sarala M. Wimalaratne, Natallia Kokash, Florent Yvon, Andrea Mari, Iñaki F. Trocóniz, Henning Hermjakob, Niels Rode Kristensen, Benjamin Ribba, Peter A. Milligan, Rikard Nordgren, Marylore Chenel, Eric Blaudez, Pascal Girard, George Davey Smith, F Mentré, Mihai Glont, Paolo Magni, Christian Laveille, K Chatel, R Bizzotto, Zinnia P. Parra-Guillen, Alain Munafo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology 4 (2015): 316–319. doi:10.1002/psp4.57
info:cnr-pdr/source/autori:Swat M.J.; Moodie S.; Wimalaratne S.M.; Kristensen N.R.; Lavielle M.; Mari A.; Magni P.; Smith M.K.; Bizzotto R.; Pasotti L.; Mezzalana E.; Comets E.; Sarr C.; Terranova N.; Blaudez E.; Chan P.; Chard J.; Chatel K.; Chenel M.; Edwards D.; Franklin C.; Giorgino T.; Glont M.; Girard P.; Grenon P.; Harling K.; Hooker A.C.; Kaye R.; Keizer R.; Kloft C.; Kok J.N.; Kokash N.; Laibe C.; Laveille C.; Lestini G.; Mentre F.; Munafo A.; Nordgren R.; Nyberg H.B.; Parra-Guillen Z.P.; Plan E.; Ribba B.; Smith G.; Troconiz I.F.; Yvon F.; Milligan P.A.; Harnisch L.; Karlsson M.; Hermjakob H.; Le Novere N./titolo:Pharmacometrics Markup Language (PharmML): Opening new perspectives for model exchange in drug development/doi:10.1002%2Fpsp4.57/rivista:CPT: Pharmacometrics & Systems Pharmacology/anno:2015/pagina_da:316/pagina_a:319/intervallo_pagine:316–319/volume:4
CPT: Pharmacometrics & Systems Pharmacology 4 (2015): 316–319. doi:10.1002/psp4.57
info:cnr-pdr/source/autori:Swat M.J.; Moodie S.; Wimalaratne S.M.; Kristensen N.R.; Lavielle M.; Mari A.; Magni P.; Smith M.K.; Bizzotto R.; Pasotti L.; Mezzalana E.; Comets E.; Sarr C.; Terranova N.; Blaudez E.; Chan P.; Chard J.; Chatel K.; Chenel M.; Edwards D.; Franklin C.; Giorgino T.; Glont M.; Girard P.; Grenon P.; Harling K.; Hooker A.C.; Kaye R.; Keizer R.; Kloft C.; Kok J.N.; Kokash N.; Laibe C.; Laveille C.; Lestini G.; Mentre F.; Munafo A.; Nordgren R.; Nyberg H.B.; Parra-Guillen Z.P.; Plan E.; Ribba B.; Smith G.; Troconiz I.F.; Yvon F.; Milligan P.A.; Harnisch L.; Karlsson M.; Hermjakob H.; Le Novere N./titolo:Pharmacometrics Markup Language (PharmML): Opening new perspectives for model exchange in drug development/doi:10.1002%2Fpsp4.57/rivista:CPT: Pharmacometrics & Systems Pharmacology/anno:2015/pagina_da:316/pagina_a:319/intervallo_pagine:316–319/volume:4
The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759ed16c9f69127554d0da81c18210d7
https://doi.org/10.1002/psp4.57
https://doi.org/10.1002/psp4.57
Autor:
Nick Juty, Nicolas Rodriguez, Sarah M. Keating, Raza Ali, Camille Laibe, Vijayalakshmi Chelliah, Sarala M. Wimalaratne, Mihai Glont, N Le Novère, Henning Hermjakob, Maciej J. Swat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 4:55-68
BioModels is a reference repository hosting mathematical models that describe the dynamic interactions of biological components at various scales. The resource provides access to over 1,200 models described in literature and over 140,000 models autom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7b0c07954e742250a37e519af3706c6
https://doi.org/10.1002/psp4.3
https://doi.org/10.1002/psp4.3
Autor:
Audald Lloret-Villas, Nick Juty, Thawfeek M. Varusai, Camille Laibe, Vijayalakshmi Chelliah, N Le Novère, Henning Hermjakob
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18f4015b2c4af96907bd101bd6c3475
https://pubmed.ncbi.nlm.nih.gov/28063254
https://pubmed.ncbi.nlm.nih.gov/28063254
Autor:
R.R. Adams, N. Tsorman, K. Stratford, O.E. Akman, S. Gilmore, N. Juty, N. Le Novère, A.J. Millar
Publikováno v:
Journal of Biological Rhythms
Adams, R R, Tsorman, N, Stratford, K, Akman, O E, Gilmore, S, Juty, N, Le Novère, N & Millar, A J 2012, ' The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models ', Journal of biological rhythms, vol. 27, no. 4, pp. 328-332 . https://doi.org/10.1177/0748730412451077
Adams, R R, Tsorman, N, Stratford, K, Akman, O E, Gilmore, S, Juty, N, Le Novère, N & Millar, A J 2012, ' The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models ', Journal of biological rhythms, vol. 27, no. 4, pp. 328-332 . https://doi.org/10.1177/0748730412451077
Time-dependent light input is an important feature of computational models of the circadian clock. However, publicly available models encoded in standard representations such as the Systems Biology Markup Language (SBML) either do not encode this inp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a81c3d7a82ad2db74060b8b13c72b4
http://europepmc.org/articles/PMC3423168
http://europepmc.org/articles/PMC3423168
Publikováno v:
Journal of Molecular Biology. 308:541-553
We recently suggested that the sensitivity and range of a cluster of membrane receptors in bacteria would be enhanced by cooperative interactions between neighbouring proteins. Here, we examine the consequences of this "conformational spread" mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814f2205044c924129bacbbbbfe6d228
https://doi.org/10.1006/jmbi.2001.4610
https://doi.org/10.1006/jmbi.2001.4610
Autor:
N. Le Novère
Computational neurosciences and systems biology are among the main domains of life science research where mathematical modeling made a difference. This book introduces the many different types of computational studies one can develop to study neurona
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Diabetes is a chronic and complex multifactorial disease caused by persistent hyperglycemia and for which underlying pathogenesis is still not completely understood. The mathematical modeling of glucose homeostasis, diabetic condition, and its associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b28e9324a0bdf1c3440b96a4c63b82
https://pubmed.ncbi.nlm.nih.gov/23842097
https://pubmed.ncbi.nlm.nih.gov/23842097