Zobrazeno 1 - 10
of 162
pro vyhledávání: '"N. Lawton"'
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106444- (2023)
Summary: P53 is a master transcriptional regulator and effector of the DNA damage response (DDR) that localizes to DNA damage sites, in part, via an interaction with PARP1. However, the mechanisms that regulate p53 abundance and activity at PARP1-dec
Externí odkaz:
https://doaj.org/article/1a25c30a47ef4be387c3ab40b42f1601
Autor:
Pei-Suen Tsou, Chenyang Lu, Mikel Gurrea-Rubio, Sei Muraoka, Phillip L. Campbell, Qi Wu, Ellen N. Model, Matthew E. Lind, Sirapa Vichaikul, Megan N. Mattichak, William D. Brodie, Jonatan L. Hervoso, Sarah Ory, Camila I. Amarista, Rida Pervez, Lucas Junginger, Mustafa Ali, Gal Hodish, Morgan M. O’Mara, Jeffrey H. Ruth, Aaron M. Robida, Andrew J. Alt, Chengxin Zhang, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, Tristan Maerz, Thomas L. Saunders, Vincent E. Groppi, David A. Fox, M. Asif Amin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
CD13, an ectoenzyme on myeloid and stromal cells, also circulates as a shed, soluble protein (sCD13) with powerful chemoattractant, angiogenic, and arthritogenic properties, which require engagement of a G protein–coupled receptor (GPCR). Here we i
Externí odkaz:
https://doaj.org/article/e5e9835fa1944ab4a428208a7bd7d3dd
Autor:
Kirsty Wienand, Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, David Wu, Jaegil Kim, Atanas Kamburov, Timothy R. Wood, Fathima Zumla Cader, Matthew D. Ducar, Aaron R. Thorner, Anwesha Nag, Alexander T. Heubeck, Michael J. Buonopane, Robert A. Redd, Kamil Bojarczuk, Lee N. Lawton, Philippe Armand, Scott J. Rodig, Jonathan R. Fromm, Gad Getz, Margaret A. Shipp
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4065-4080 (2019)
Abstract: Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed-Sternberg (HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS cells exhibit near-universal somatic copy gains of chromosome 9
Externí odkaz:
https://doaj.org/article/fb5ce2af40844774bf1b968171dded99
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
Autor:
Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Lynne Rokita, John M. Maris, Richard A. Young, A. Thomas Look, Takaomi Sanda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the differentiation of neurons, demonstrating that ASCL1 is
Externí odkaz:
https://doaj.org/article/e6eb4888c5884e66bc019c078ad386b1
Autor:
Linfeng Chen, Jing Ouyang, Kirsty Wienand, Kamil Bojarczuk, Yansheng Hao, Bjoern Chapuy, Donna Neuberg, Przemyslaw Juszczynski, Lee N. Lawton, Scott J. Rodig, Stefano Monti, Margaret A. Shipp
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
B-cell receptor (BCR) signaling pathway components represent promising treatment targets in multiple B-cell malignancies including diffuse large B-cell lymphoma (DLBCL). In in vitro and in vivo model systems, a subset of DLBCLs depend upon BCR surviv
Externí odkaz:
https://doaj.org/article/e45df442ab06411b89d31bae3d7a29df
Autor:
RICKY N. LAWTON, DANIEL FUJIWARA
Publikováno v:
Climate Change Economics. 14
Following the UK’s hosting of the United Nations Convention of the Parties Climate Summit in 2021, political targets for reducing greenhouse gas emissions — “Net-Zero” — have gained momentum. We address the gap in how public preferences are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::061fd6cdd96d377e0dc1bc15cb68781f
https://doi.org/10.1142/s2010007823500070
https://doi.org/10.1142/s2010007823500070
Publikováno v:
Journal of Cultural Economics
With the passage of time, celluloid film degrades and valuable film history is lost, resulting in loss of cultural history which contributes to the shared sense of community, identify, and place at a local and national level. Despite the growth in di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddf575753922bd7b2e99a7cc349abdf
https://doi.org/10.1007/s10824-021-09414-7
https://doi.org/10.1007/s10824-021-09414-7
Akademický článek
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Autor:
David J. Hosfield, Jiangchun Xu, Young K. Chen, Matt M. Kreilein, James Marvin Veal, Chon Lai, Christophe Severin, Toufike Kanouni, Stephen W. Kaldor, Lee N. Lawton, Robert Cho, Joselyn R. Del Rosario, Ryan Stansfield, Jeffrey A. Stafford, Natalie Y.-Y. Yuen, Shawn O’Connell, Paula Alessandra Tavares-Greco, Zhe Nie, Lihong Shi
Publikováno v:
Journal of Medicinal Chemistry. 63:14522-14529
Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are hallmarks of a number of human dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ec0fbdb2c348ac2a377e0b118afeee
https://doi.org/10.1021/acs.jmedchem.0c00978
https://doi.org/10.1021/acs.jmedchem.0c00978
Autor:
Wenjiang Ma, Philippe Armand, Pei-Hsuan Chen, Jason L. Weirather, Xihao Hu, Fathima Zumla Cader, Lee N. Lawton, Margaret A. Shipp, Ron C. J. Schackmann, Robert A. Redd, Elisa Mandato, Jing Ouyang, Scott J. Rodig, Walter Goh, Bo Li, Donna Neuberg, Kirsty Wienand, X. Shirley Liu
Publikováno v:
Nat Med
PD-1 blockade is highly effective in classical Hodgkin lymphomas (cHLs), which exhibit frequent copy-number gains of CD274 (PD-L1) and PDC1LG2 (PD-L2) on chromosome 9p24.1. However, in this largely MHC-class-I-negative tumor, the mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf708a4672044835c3e5a2c915d086c3
https://doi.org/10.1038/s41591-020-1006-1
https://doi.org/10.1038/s41591-020-1006-1