Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis

Autor: N. Laufhäger, David J. Lamb, Paul Dietl, T. Kiechle, Nicolas Pairet, Samuel Mang

Publikováno v: Biochemistry and Biophysics Reports, Vol 20, Iss, Pp-(2019)
Biochemistry and Biophysics Reports

Transient receptor potential vanilloid 4 (TRPV4) has been implicated in many disease conditions also in the lung. Its activation leads to an increase endothelial permeability in an intracellular calcium-influx dependent manner. We investigated its fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a470dc30e7ac2802a085952ad0be59
https://pubmed.ncbi.nlm.nih.gov/31650038

Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis.

Autor: Pairet N; Institute of General Physiology, University of Ulm, Ulm, Germany.; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, D-88397, Biberach an der Riß, Germany., Mang S; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, D-88397, Biberach an der Riß, Germany.; Institute of Immunology, Hannover Medical School, D-30625, Hannover, Germany., Kiechle T; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, D-88397, Biberach an der Riß, Germany., Laufhäger N; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, D-88397, Biberach an der Riß, Germany., Dietl P; Institute of General Physiology, University of Ulm, Ulm, Germany., Lamb DJ; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, D-88397, Biberach an der Riß, Germany.

Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2019 Sep 19; Vol. 20, pp. 100672. Date of Electronic Publication: 2019 Sep 19 (Print Publication: 2019).