Zobrazeno 1 - 9
of 9
pro vyhledávání: '"N. L. Gowrishankar"'
Publikováno v:
Rasayan Journal of Chemistry. 15:497-503
In human breast cancers, the human epidermal development factor receptor-2 is a membrane tyrosine kinase that is overexpressed, and gene amplified. Pyrazolone fused heterocyclic moieties- thiazolidinone, carboxymethyl thiazolidinone, azetidinone are
Publikováno v:
Research Journal of Pharmacy and Technology. :2095-2100
Objective: Drug nanoparticles offer a versatile platform for enhancing the dissolution rate and bioavailability of poorly water soluble drugs The present study was aimed to design and develop dasatinib (DAS) loaded Poly lactide co glycolic acid (PLGA
Autor:
Pappu S Swapanthi, Deshetti Bhagya, Gisela Ileana Mazaira, C. V. S. Subrahmanyam, Mario D. Galigniana, N. L. Gowrishankar, Sayan Dutta Gupta, Nulgumnalli Manjunathaiah Raghavendra, Fernando Federicci
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:369-385
Background: Heat shock protein 90 (Hsp90) is an encouraging anticancer target for the development of clinically significant molecules. Schiff bases play a crucial role in anticancer research because of their ease of synthesis and excellent antiprolif
Autor:
C. V. S. Subrahmanyam, Sayan Dutta Gupta, Nulgumnalli Manjunathaiah Raghavendra, N. L. Gowrishankar
Publikováno v:
Indian Journal of Pharmaceutical Sciences. 82
In this study a methodology was described to recognize the conserved water molecules required for efficient binding of ligands with heat shock protein. Subsequently, a substantiated procedure for the determination of an effective docking methodology
Publikováno v:
Indian Journal of Pharmaceutical Sciences. 80
Targeting of drugs to brain is one of the most challenging issues for pharmaceutical research as blood-brain barrier acts as an insurmountable obstacle for the passage of systemically delivered therapeutics and the brain extracellular matrix attribut
Autor:
Manish Kumar Bommaka, Gisela Ileana Mazaira, C. V. S. Subrahmanyam, Sayan Dutta Gupta, Nulgumnalli Manjunathaiah Raghavendra, N. L. Gowrishankar, Mario D. Galigniana
Publikováno v:
International Journal of Biological Macromolecules. 80:253-259
The ubiquitously expressed heat shock protein 90 is an encouraging target for the development of novel anticancer agents. In a program directed towards uncovering novel chemical scaffolds against Hsp90, we performed molecular docking studies using Tr
Autor:
Sayan Dutta Gupta, Gisela Ileana Mazaira, D. Snigdha, Mario D. Galigniana, N. L. Gowrishankar, Nulgumnalli Manjunathaiah Raghavendra, C. V. S. Subrahmanyam
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Heat shock protein 90 (Hsp90) is an emerging attractive target for the discovery of novel cancer therapeutic agents. Docking methods are powerful in silico tools for lead generation and optimization. In our mission to rationally develop novel effecti
Publikováno v:
Pharmaceutical Chemistry Journal. 46:381-385
3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose has emerged as structurally new antibacterial and anti-inflammatory agent. Therefore, various substituted bis-indolyl- (3-O-benzyl-1,2-O-isopropylidene-xylopentadialdose glucofuranose) derivatives wer
Autor:
N. L. Gowrishankar, Sayan Dutta Gupta, B. Revathi, C. V. S. Subrahmanyam, Mario D. Galigniana, Gisela Ileana Mazaira, Nulgumnalli Manjunathaiah Raghavendra
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Hsp90 is a molecular chaperone that heals diverse array of biomolecules ranging from multiple oncogenic proteins to the ones responsible for development of resistance to chemotherapeutic agents. Moreover they are over-expressed in cancer cells as a c