Zobrazeno 1 - 10
of 36
pro vyhledávání: '"N. L. Alderson"'
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 7, Pp 1440-1449 (2005)
Chemical modification of proteins by advanced glycation and lipoxidation end products is implicated in the pathogenesis of macrovascular disease in aging and diabetes. To identify biomarkers of the lipoxidative modification of protein, we studied the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dd9cb4ff015ecd5240b706cb20bc3c
https://doi.org/10.1194/jlr.m400442-jlr200
https://doi.org/10.1194/jlr.m400442-jlr200
Autor:
Thera P. Links, J. J. Jager, P. H. N. Oomen, Robbert Meerwaldt, Reinold O. B. Gans, Suzanne R. Thorpe, Andries J. Smit, John W. Baynes, Reindert Graaff, N. L. Alderson
Publikováno v:
Diabetologia, 47(7), 1324-1330. SPRINGER
Aims/hypothesis. The accumulation of AGE is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. All current measurements of AGE accumulation require invasive sampling. We exploited the fact that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd2da4db74b5092ca610595eb1cb1c3
https://doi.org/10.1007/s00125-004-1451-2
https://doi.org/10.1007/s00125-004-1451-2
Autor:
Suzanne R. Thorpe, Nadja Alt, N. L. Alderson, James A. Carson, Ryoji Nagai, Thomas Henle, John W. Baynes, Yuping Wang
Publikováno v:
Archives of Biochemistry and Biophysics. 425:200-206
Levels of glycation (fructose-lysine, FL) and advanced glycoxidation and lipoxidation end-products (AGE/ALEs) were measured in total skeletal (gastrocnemius) muscle and myofibril protein and compared to levels of the same compounds in insoluble skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4d2c9210e08774b839033d6eedd132
https://doi.org/10.1016/j.abb.2004.03.012
https://doi.org/10.1016/j.abb.2004.03.012
Publikováno v:
Biochemical Society Transactions. 31:1413-1416
Hyperglycaemia is the major risk factor for the development of complications in both Type I and Type II diabetes; however, there is growing evidence from several clinical trials that dyslipidaemia, including hypertriglyceridaemia, is a significant an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75c266b42a46ce79ae609256ee899e2
https://doi.org/10.1042/bst0311413
https://doi.org/10.1042/bst0311413
Publikováno v:
Archives of Biochemistry and Biophysics. 419:41-49
Pyridoxamine (PM), originally described as a post-Amadori inhibitor of formation of advanced glycation end-products (AGEs), also inhibits the formation of advanced lipoxidation end-products (ALEs) on protein during lipid peroxidation reactions. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad82c21052c609c9000cf9ba0b2e0a44
https://doi.org/10.1016/j.abb.2003.08.021
https://doi.org/10.1016/j.abb.2003.08.021
Publikováno v:
Journal of Biological Chemistry. 278:42012-42019
Maillard or browning reactions between reducing sugars and protein lead to formation of advanced glycation end products (AGEs) and are thought to contribute to the pathogenesis of diabetic complications. AGE inhibitors such as aminoguanidine and pyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9197aa94582f33b2843379d70eabedc5
https://doi.org/10.1074/jbc.m304292200
https://doi.org/10.1074/jbc.m304292200
Autor:
N. L. Alderson, John W. Baynes, Nancy N. Youssef, Mark E. Chachich, Maurice Nachtigal, Suzanne R. Thorpe, Robert J. Beattie
Publikováno v:
Kidney International. 63:2123-2133
The AGE inhibitor pyridoxamine inhibits lipemia and development of vascular and renal disease in Zucker obese rats. Background In previous studies, pyridoxamine (PM) limited the formation of advanced glycation end products (AGEs) and development of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa83af86f21c9b772aca5f2e91e5f1e
https://doi.org/10.1046/j.1523-1755.2003.00027.x
https://doi.org/10.1046/j.1523-1755.2003.00027.x
Autor:
Francesco Wagner, Gabriel Virella, Elias M. Stephan, Maria F. Lopes-Virella, Daniel H. Atchley, Suzanne R. Thorpe, N. L. Alderson
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 3, Pp 487-493 (2003)
Advanced glycosylation end-products (AGEs) are believed to play a significant role in the development of vascular complications in diabetic patients. One such product, AGE-LDL, has been shown to be immunogenic. In this report, we describe the isolati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2caa8ed5a3cc0a819e79af594996cca5
https://doi.org/10.1194/jlr.m200370-jlr200
https://doi.org/10.1194/jlr.m200370-jlr200
Autor:
P. E. Mosher, N. L. Alderson, M. A. Ferguson, Stewart G. Trost, Paul K. Davis, J. L. Durstine
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 63:73-80
The purpose of this study was to examine the effect of prolonged exercise on plasma lipid and lipoprotein concentrations and to identify caloric time-points where changes occurred. Eleven active male subjects ran on a treadmill at 70% of maximal fitn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888125d6823387e115646fac33da97e0
https://doi.org/10.1080/00365510308583
https://doi.org/10.1080/00365510308583
Autor:
Andrzej Januszweski, Alan W. Stitt, Suzanne R. Thorpe, Agnieszka M. Lichanska, N. L. Alderson, Tom A. Gardiner, Stephanie M Jimenez, Norma Frizzell, Paul Canning, Mark E. Chachich, Nancy N. Youssef, John W. Baynes
Publikováno v:
International Congress Series. 1245:169-173
We hypothesized that the beneficial effects of a variety of pharmacological agents on the progression of diabetic complications were mediated by a common pathway limiting the formation of advanced glycation and advanced lipoxidation end products (AGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13f1a9a0e9523cbc768b7d413b6c84c0
https://doi.org/10.1016/s0531-5131(02)01002-6
https://doi.org/10.1016/s0531-5131(02)01002-6