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Akademický článek

Technical Review of Clinical Outcomes Assessments Across the Continuum of Alzheimer's Disease

Publikováno v: Neurology and Therapy, Vol 12, Iss 2, Pp 571-595 (2023)

Abstract Introduction Insight into the relationship between concepts that matter to the people affected by Alzheimer’s disease (AD) and the clinical outcome assessments (COAs) commonly used in AD clinical studies is limited. Phases 1 and 2 of the W

Externí odkaz: https://doaj.org/article/4563c68c02c441bda9571595e1d88641

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Akademický článek

Assessing What Matters to People Affected by Alzheimer’s Disease: A Quantitative Analysis

Publikováno v: Neurology and Therapy, Vol 12, Iss 2, Pp 505-527 (2023)

Abstract Introduction In this phase of the ongoing What Matters Most study series, designed to evaluate concepts that are meaningful to people affected by Alzheimer’s disease (AD), we quantified the importance of symptoms, impacts, and outcomes of

Externí odkaz: https://doaj.org/article/3e5b9fbbd452432f931fe5334ada2652

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Akademický článek

Assessing what matters most to patients with or at risk for Alzheimer’s and care partners: a qualitative study evaluating symptoms, impacts, and outcomes

Autor: Dana B. DiBenedetti, Christina Slota, Samantha L. Wronski, George Vradenburg, Meryl Comer, Leigh F. Callahan, John Winfield, Ivana Rubino, Holly B. Krasa, Ann Hartry, Dan Wieberg, Ian N. Kremer, Debra Lappin, Allison D. Martin, Terry Frangiosa, Virginia Biggar, Brett Hauber

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020)

Abstract Background The What Matters Most (WMM) study was initiated to evaluate symptoms, AD-related impacts, treatment-related needs, preferences, and priorities among individuals with or at risk for Alzheimer’s disease (AD) and their care partner

Externí odkaz: https://doaj.org/article/5cc835866e684736885a9b7f9e22351c

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Akademický článek

Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens

Autor: Hannah Reimann, Edith D van der Meijden, Judith Bausenwein, Sascha Kretschmann, Anna Luise Bernhardt, Julia Zeun, Miriam Marecek, Margarete M Karg, Tabea Haug, Lisa Meintker, Gloria Lutzny-Geier, Anita N Kremer

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)

Background Graft-versus-host-disease (GvHD) is a major problem in allogeneic stem cell transplantation. We previously described two types of endogenous human leukocyte antigen (HLA)-II restricted antigens depending on their behavior towards HLA-DM. W

Externí odkaz: https://doaj.org/article/bcc0d925c21d4c1b89cc3f57512617d1

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Akademický článek

Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy

Autor: James L Gulley, Andrew Nguyen, Shahrooz Rabizadeh, Kayvan Niazi, Duane H Hamilton, Marieke Griffioen, Stephen C Benz, Patricia Spilman, Peter A Fasching, Matthias W Beckmann, Matthias Ruebner, J Zachary Sanborn, Charles J Vaske, Karin L Lee, Anita N. Kremer

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Background Therapeutic regimens designed to augment the immunological response of a patient with breast cancer (BC) to tumor tissue are critically informed by tumor mutational burden and the antigenicity of expressed neoepitopes. Herein we describe a

Externí odkaz: https://doaj.org/article/c6c241c5fc884858ab13b1108e690d29

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Akademický článek

Vascular occlusion by neutrophil extracellular traps in COVID-19

Publikováno v: EBioMedicine, Vol 58, Iss , Pp 102925- (2020)

Background: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Methods: Samples

Externí odkaz: https://doaj.org/article/724dc37caf5547c390e6022a21be3717

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Akademický článek

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase

Autor: Anita N. Kremer, Judith Bausenwein, Ellie Lurvink, Andreas E. Kremer, Caroline E. Rutten, Cornelis A. M. van Bergen, Sascha Kretschmann, Edith van der Meijden, Maria W. Honders, Daniela Mazzeo, Colin Watts, Andreas Mackensen, J. H. Frederik Falkenburg, Marieke Griffioen

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs. leuke

Externí odkaz: https://doaj.org/article/2b1638512c1844b2a06d1ee783b55349

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Akademický článek

LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling

Autor: Divij Mathew, Kimberly N. Kremer, Pamela Strauch, Gabor Tigyi, Roberta Pelanda, Raul M. Torres

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Persistent T cell antigen receptor (TCR) signaling by CD8 T cells is a feature of cancer and chronic infections and results in the sustained expression of, and signaling by, inhibitory receptors, which ultimately impair cytotoxic activity via poorly

Externí odkaz: https://doaj.org/article/04ded64fa8034a9f98f2f41f0056312a

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