Zobrazeno 1 - 10
of 53
pro vyhledávání: '"N. Kinloch"'
Autor:
Z. Brumme, N. Kinloch, A. Shahid, W. Dong, D. Kirkby, B.R. Jones, C. Beelen, D. MacMillan, T.M. Mota, H. Sudderuddin, E. Barad, M. Harris, C.J. Brumme, R. Brad Jones, M.A. Brockman, J.B. Joy
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss , Pp 100186- (2022)
Externí odkaz:
https://doaj.org/article/e1b363f70d03481e80fe74ecc3eb8b39
Autor:
B. Jones, N. Kinloch, J. Horacsek, B. Ganase, M. Harris, R. Harrigan, R.B. Jones, M. Brockman, J. Joy, A. Poon, Z. Brumme
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss , Pp 27- (2017)
Externí odkaz:
https://doaj.org/article/a40fc22e24334a18a351ce8d4c65b9d8
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
Autor:
Guinevere Q. Lee, Pragya Khadka, Sarah N. Gowanlock, Dennis C. Copertino, Maggie C. Duncan, F. Harrison Omondi, Natalie N. Kinloch, Jingo Kasule, Taddeo Kityamuweesi, Paul Buule, Samiri Jamiru, Stephen Tomusange, Aggrey Anok, Zhengming Chen, R. Brad Jones, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Zabrina L. Brumme, Andrew D. Redd, Jessica L. Prodger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral landscape, which have been predominantly conducted in males in the United States and Euro
Externí odkaz:
https://doaj.org/article/8753461e8307400b835f50ad980f61a1
Autor:
Natalie N. Kinloch, Aniqa Shahid, Winnie Dong, Don Kirkby, Bradley R. Jones, Charlotte J. Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Zabrina L. Brumme
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTIn order to cure human immunodeficiency virus (HIV), we need to better understand the within-host evolutionary origins of the small reservoir of genome-intact proviruses that persist within infected cells during antiretroviral therapy (ART).
Externí odkaz:
https://doaj.org/article/1447a0402b68443b8658e7d4faad4893
Autor:
Miriam Rosás-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane Schleimann, Paul W. Denton, Victor Ramos, Adam Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escribà, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Søgaard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cel
Externí odkaz:
https://doaj.org/article/ef639b4a891643dcb296cca780fd13c0
Autor:
Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie Dong, Pragya Khadka, Szu Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin Kovacs, Erika Benko, Mario A. Ostrowski, Perla M. Del Rio Estrada, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Lynsay MacLaren, Harris Goldstein, Chanson J. Brumme, Guinevere Q. Lee, Rebecca M. Lynch, Zabrina L. Brumme, R. Brad Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The intact proviral DNA assay quantifies the genomically intact HIV reservoir, but assay failure due to HIV-1 polymorphism has been observed. Here, the authors report a 28% failure rate in a cohort of people with HIV-1, and note within-host HIV-1 div
Externí odkaz:
https://doaj.org/article/2f1b4a3b13f745078fbaecf15223c1ef
Autor:
F. Harrison Omondi, Hanwei Sudderuddin, Aniqa Shahid, Natalie N. Kinloch, Bradley R. Jones, Rachel L. Miller, Olivia Tsai, Daniel MacMillan, Alicja Trocha, Mark A. Brockman, Chanson J. Brumme, Jeffrey B. Joy, Richard Liang, Bruce D. Walker, Zabrina L. Brumme
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Curing HIV will require eliminating the reservoir of integrated, replication-competent proviruses that persist despite antiretroviral therapy (ART). Understanding the burden, genetic diversity, and longevity of persisting proviruses in diver
Externí odkaz:
https://doaj.org/article/e29d5e60d3034aedb7b7c5c53808e009
Autor:
Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie Dong, Pragya Khadka, Szu Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin Kovacs, Erika Benko, Mario A. Ostrowski, Perla M. Del Rio Estrada, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Lynsay MacLaren, Harris Goldstein, Chanson J. Brumme, Guinevere Q. Lee, Rebecca M. Lynch, Zabrina L. Brumme, R. Brad Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/d63b13d33e68408f9ca3dd6ccf322f0f
Autor:
Julie S. Nielsen, Andrew R. Chang, Darin A. Wick, Colin G. Sedgwick, Zusheng Zong, Andrew J. Mungall, Spencer D. Martin, Natalie N. Kinloch, Susann Ott-Langer, Zabrina L. Brumme, Steven P. Treon, Joseph M. Connors, Randy D. Gascoyne, John R. Webb, Brian R. Berry, Ryan D. Morin, Nicol Macpherson, Brad H. Nelson
Publikováno v:
OncoImmunology, Vol 6, Iss 7 (2017)
Oncogenic “driver” mutations are theoretically attractive targets for the immunotherapy of lymphoid cancers, yet the proportion that can be recognized by T cells remains poorly defined. To address this issue without any confounding effects of the
Externí odkaz:
https://doaj.org/article/fb3d07d87ea0480292f902b4900879f2
Autor:
Danielle K. Sohai, Michael Keller, Patrick J. Hanley, Anushree Datar, Emily Reynolds, Dennis Copertino, Chase McCann, Haili Lang, Cecilia Motta, Andrew Wilson, Rebecca Lynch, Winiffer Conce Alberto, Zabrina L. Brumme, Natalie N. Kinloch, Conrad Russell Y. Cruz, Lynsay MacLaren Ehui, Sarah Henn, R. Brad Jones, Catherine M Bollard
Publikováno v:
Blood. 140:7498-7499