Zobrazeno 1 - 10
of 60
pro vyhledávání: '"N. K. Zenkov"'
Autor:
S. E. Khrapov, P. M. Kozhin, M. V. Khrapova, A. E. Serykh, L. P. Romakh, V. S. Pavlov, A. V. Chechushkov, S. V. Kholshin, N. K. Zenkov, E. B. Menshchikova
Publikováno v:
Сибирский научный медицинский журнал, Vol 41, Iss 3, Pp 25-31 (2021)
Under certain conditions, both activators and inhibitors of Nrf2-dependent signaling and autophagy can serve as potential agents for the prevention, treatment, and maintenance therapy of cancer, as well as overcoming chemoresistance. We are developin
Externí odkaz:
https://doaj.org/article/b5fda36ed7084758af04b032e864aa8b
Autor:
E. B. Menshchikova, N. K. Zenkov, P. M. Kozhin, A. V. Chechushkov, V. S. Pavlov, L. P. Romakh, M. V. Khrapova, A. E. Serykh, O. B. Gritsyk, N. V. Kandalintseva
Publikováno v:
Сибирский научный медицинский журнал, Vol 40, Iss 6, Pp 58-69 (2020)
Understanding the role of reactive oxygen and nitrogen species in eustress (redox balance) and distress (oxidative stress) development poses new challenges for biomedical scientists and pharmacologists in the search for compounds that can not only ha
Externí odkaz:
https://doaj.org/article/d474da70577948f88ecfc58d526ab64c
Autor:
N. K. Zenkov, A. V. Chehushkov, P. M. Kozhin, G. G. Martinovich, N. V. Kandalintseva, E. B. Menshchikova
Publikováno v:
Бюллетень сибирской медицины, Vol 18, Iss 2, Pp 195-214 (2019)
Autophagy is the main catabolic process required for the removal of damaged organelles, aggregated proteins and intracellular pathogens from cells. Oxidative stress is accompanied by an increase in autophagy, which has a protective effect by maintain
Externí odkaz:
https://doaj.org/article/3dd073a9e9164a6eaa1e66ede1017681
Autor:
N. K. Zenkov, P. M. Kozhin, A. V. Vcherashnyaya, G. G. Martinovich, N. V. Kandalintseva, E. B. Menshchikova
Publikováno v:
Сибирский научный медицинский журнал, Vol 39, Iss 2, Pp 11-26 (2019)
Endogenous mechanisms of reactive oxygen (ROS) and nitrogen species production and of antioxidant defense systems in tumor cells are analyzed. Increased ROS production is an important regulator of metabolic changes in these cells: enhanced proliferat
Externí odkaz:
https://doaj.org/article/57059c42a168468798b406cd20866ae2
Autor:
P. I. Gaynutdinov, P. M. Kozhin, A. V. Chechushkov, G. G. Martinovich, S. V. Kholshin, N. V. Kandalintseva, N. K. Zenkov, E. B. Menshchikova
Publikováno v:
Сибирский научный медицинский журнал, Vol 38, Iss 1, Pp 22-31 (2019)
The aim of the study was to study investigate the relationship between the antioxidant activity of new synthetic structurally related water-soluble monophenols and their effect on the tumor cell viability in vitro. Material and methods. Five original
Externí odkaz:
https://doaj.org/article/9aee845f3df24acb8dba91409904e7aa
Autor:
P. M. Kozhin, A. V. Kovner, N. K. Zenkov, T. I. Petrenko, N. V. Kandalintseva, E. B. Menshchikova
Publikováno v:
Сибирский научный медицинский журнал, Vol 38, Iss 1, Pp 5-11 (2019)
The aim of the study was to determine the dose of a virulent strain of Mycobacterium tuberculosis H37Rv that is optimal for modeling experimental tuberculosis granulomatosis in mice and to investigate the effect of the original inductor of the Keap1/
Externí odkaz:
https://doaj.org/article/fb15bafe3f554f38b02d0fdfff4dddff
Autor:
E. B. Menshchikova, N. K. Zenkov
Publikováno v:
Acta Biomedica Scientifica, Vol 1, Iss 3(2), Pp 174-180 (2016)
The concept of oxidative stress remains attractive to researchers combining the chemical nature of activated oxygen metabolites (AOM] and antioxidants, physical and biochemical mechanisms of action, including conditional simplicity of their versatili
Externí odkaz:
https://doaj.org/article/8e090d67114d4dc09cbd00086b3ff2ef
Autor:
P. M. Kozhin, N. K. Zenkov, A. V. Chechushkov, N. S. Zaytseva, N. V. Kandalintseva, E. B. Menshchikova
Publikováno v:
Acta Biomedica Scientifica, Vol 1, Iss 3(2), Pp 92-95 (2016)
The emergence of drug-resistant TB caused by resistance to antibiotic strains of bacteria, prompted to search for new "organism-oriented" ("host-targeted") adjuvant treatment strategies. Free radical oxidation plays an important role in the developme
Externí odkaz:
https://doaj.org/article/ece0e2e1174a4d0ab8f692336b680645
Publikováno v:
Туберкулез и болезни лёгких, Vol 94, Iss 3, Pp 8-19 (2016)
Autophagy is an important immune mechanism defining the host resistance to intracellular pathogens and tuberculous mycobacteria in particular. Autophagy is involved into direct elimination of the pathogenic agent, control of immune reactions of the h
Externí odkaz:
https://doaj.org/article/f3992b58c8384142b5bbd64d9fa64081
Autor:
Sergey N. Cherenkevich, E. B. Menshchikova, G. G. Martinovich, N. K. Zenkov, I. V. Martinovich, A. V. Vcherashniaya
Publikováno v:
Biophysics. 65:920-930
Pharmacological modification of the redox properties of tumor cells is a promising approach to enhance the efficiency of antitumor therapy. The Nrf2 transcription factor is considered as a new target for the development of selective chemosensitizers.