Zobrazeno 1 - 10
of 76
pro vyhledávání: '"N. Jeffreys"'
Autor:
Shaowei Zhang, Laura N. Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O. Johannissen, Lingyun Zhu, Matthew J. Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W. Levy, David Leys, Derren J. Heyes, Nigel S. Scrutton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme B12) can act as a light-sensing chromophore heralded a new field of B12-photobiology. Although mi
Externí odkaz:
https://doaj.org/article/a0f44c530eda465fa74001ba20e7cc49
Autor:
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J. Heyes, Muralidharan Shanmugam, Adam Brookfield, Linus O. Johannissen, Colin W. Levy, Laura N. Jeffreys, Shaowei Zhang, Michiyo Sakuma, Jacques-Philippe Colletier, Sam Hay, Giorgio Schirò, Martin Weik, Nigel S. Scrutton, David Leys
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract CarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a seri
Externí odkaz:
https://doaj.org/article/001606f7b0874be9a4255441eb03bd98
Autor:
Laura N. Jeffreys, Alison Ardrey, Taghreed A. Hafiz, Lauri-Anne Dyer, Ashley J. Warman, Nada Mosallam, Gemma L. Nixon, Nicholas E. Fisher, W. David Hong, Suet C. Leung, Ghaith Aljayyoussi, Jaclyn Bibby, Deepak V. Almeida, Paul J. Converse, Nader Fotouhi, Neil G. Berry, Eric L. Nuermberger, Anna M. Upton, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
ACS Infectious Diseases. 9:221-238
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11380 (2021)
CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated from Bacillus megaterium, which displays similar metabolic capabilities to many drug-metabolizing human P450 isoforms. BM3′s high catalytic efficiency, ease o
Externí odkaz:
https://doaj.org/article/5d9b5c24683a4f389d4469fba5f9a5c4
Autor:
N Penney, J Dirie, N Jeffreys, A Siddig, A Currie, A Kamocka, P Prabhu, N Abbassi-Ghadi, P Singh, S R Preston
Publikováno v:
Diseases of the Esophagus. 35
Background and aim The role of perioperative chemotherapy in oesophago-gastric adenocarcinoma is well established. Epirubicin, Cisplatin/Oxaliplatin and Capecitabine (ECX/EOX) based regimens have recently been challenged by Fluoruracil, Leucovorin, O
Autor:
Helen Box, Shaun H Pennington, Edyta Kijak, Lee Tatham, Claire H Caygill, Rose C Lopeman, Laura N Jeffreys, Joanne Herriott, Joanne Sharp, Megan Neary, Anthony Valentijn, Henry Pertinez, Paul Curley, Usman Arshad, Rajith KR Rajoli, Steve Rannard, James P. Stewart, Giancarlo A Biagini, Andrew Owen
Antiviral interventions are urgently required to support vaccination programmes and reduce the global burden of COVID-19. Prior to initiation of large-scale clinical trials, robust preclinical data in support of candidate plausibility are required. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced3ede5533d4549e2592e3ab29697ed
https://doi.org/10.1101/2022.03.03.482788
https://doi.org/10.1101/2022.03.03.482788
Autor:
Ysaias José Alvarado, Yosmari Olivarez, Carla Lossada, Joan Vera-Villalobos, José Luis Paz, Eddy Vera, Marcos Loroño, Alejandro Vivas, Fernando Javier Torres, Laura N. Jeffreys, María Laura Hurtado-León, Lenin González-Paz
Publikováno v:
Computational biology and chemistry. 99
The COVID-19 pandemic has accelerated the study of drugs, most notably ivermectin and more recently Paxlovid (PF-07321332) which is in phase III clinical trials with experimental data showing covalent binding to the viral protease M
Autor:
Lenin González, Carla Lossada, María Laura Hurtado-León, Francelys V. Fernández-Materán, Edgar Portillo, Joan Vera-Villalobos, Marcos Loroño, J. L. Paz, Laura N. Jeffreys, María Dolores Fernández, Ysaias J. Alvarado
Publikováno v:
SSRN Electronic Journal.
Akademický článek
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Autor:
Laura N Jeffreys, Shaun H Pennington, Jack Duggan, Claire H Caygill, Rose C Lopeman, Alastair F Breen, Jessica B Jinks, Alison Ardrey, Samantha Donnellan, Edward I Patterson, Grant L Hughes, David W Hong, Paul M O’Neill, Ghaith Aljayyoussi, Andrew Owen, Stephen A Ward, Giancarlo A Biagini
A key element to the prevention and management of the COVID-19 pandemic is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer a number of advantages to monotherapies including the potential to achieve gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3be06334fa54c60b7259c9da3758b2a
https://doi.org/10.1101/2020.12.23.424232
https://doi.org/10.1101/2020.12.23.424232