Zobrazeno 1 - 6 of 6 pro vyhledávání: '"N. J. Smeulers"'
1
Hypothermic cardiopulmonary bypass influences the concentration-response relationship and the biodisposition of rocuronium
Autor: N J, Smeulers, J M, Wierda, L, van den Broek, R C, Gallandat Huet, P J, Hennis
Publikováno v: European Journal of Anaesthesiology. 12:91-94
In 10 patients scheduled for elective coronary artery bypass grafting under midazolam-sufentanil anaesthesia, the influence of hypothermia on the plasma concentration-response and biodisposition of rocuronium were investigated. Neuromuscular function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::00acc5e55b5c71b169ba2b4a794e1a3e
https://www.ncbi.nlm.nih.gov/pubmed/8557015
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2
Clinical pharmacology of rocuronium (ORG 9426): Study of the time course of action, dose requirement, reversibility, and pharmacokinetics
Autor: Pim J. Hennis, Lambertus van den Broek, N. J. Smeulers, Gert Jan van Santen, J.Mar K.H. Wierda, Monique G.L. Leclercq
Publikováno v: Journal of Clinical Anesthesia. 6:288-296
Study Objective: To evaluate the time course of action, dose requirement, reversibility, and pharmacokinetics of rocuronium (Org 9426) under 3 anesthetic techniques (nitrous oxide-fentanyl supplemented with propofol, halothane, or isoflurane). Design
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c694abf112900c529ecd70d1385e50e
https://doi.org/10.1016/0952-8180(94)90075-2
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3
Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487
Autor: A. M. Beaufort, Sandor Agoston, N. J. Smeulers, Jmkh Wierda, U. W. Kleef
Publikováno v: Canadian Journal of Anaesthesia. 41:213-220
Three muscle relaxants, Org 9453, Org 9489 and Org 9487, short-acting in animals, were investigated to establish their profiles in humans. Potency, time course of action, and pharmacokinetic behaviour were studied in 90 healthy patients during fentan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f24f1e0902681c9990d6243335f5a62
https://doi.org/10.1007/bf03009833
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4
Effects of hypothermic cardiopulmonary bypass on the pharmacodynamics and pharmacokinetics of rocuronium
Autor: Lambertus van den Broek, Pim J. Hennis, J. Mark K.H. Wierda, Rolf C.G. Gallandat Huet, N. J. Smeulers
Publikováno v: Journal of cardiothoracic and vascular anesthesia. 9(6)
Objective: To study the influence of hypothermic cardiopulmonary bypass (CPB) on the pharmacodynamics and pharmacokinetics of rocuronium. Design: Prospective, descriptive study. Setting: Operating room at a university hospital. Participants: Ten ASA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8189cd6aa938f1576201727b12ef5fe6
https://pubmed.ncbi.nlm.nih.gov/8664462
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5
Pharmacodynamics and pharmacokinetics of an infusion of Org 9487, a new short-acting steroidal neuromuscular blocking agent
Autor: L. van den Broek, N. J. Smeulers, Johannes H. Proost, J. M. K. H. Wierda
Publikováno v: British Journal of Anaesthesia, 73(3), 331-335. ELSEVIER SCI LTD
We have evaluated in 10 anaesthetized patients the time course of action, infusion requirements, reversibility and pharmacokinetics of Org 9487. Org 9487 was administered as a bolus dose of 1.5 mg kg(-1), followed by an infusion to maintain a block o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed192f7d0634e4a46eb340058e3b206
https://research.rug.nl/en/publications/bc91b2d0-0220-43c9-808f-37b202e0cb46
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