Výsledky vyhledávání - "N. J. Parsons"

Lactate Stimulation of Gonococcal Metabolism in Media Containing Glucose: Mechanism, Impact on Pathogenicity, and Wider Implications for Other Pathogens

Autor: Harry Smith, Edwin A. Yates, N. J. Parsons, Jeffrey A. Cole

Publikováno v: Infection and Immunity. 69:6565-6572

Over the past decade, studies of Neisseria gonorrhoeae have shown that in media containing glucose, lactate stimulates metabolism, and this could affect pathogenicity (7, 19). Recently, the probable mechanism of this stimulation has been identified a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af803f8e5e40efc15fec7a739795de9b
https://doi.org/10.1128/iai.69.11.6565-6572.2001

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Lactic acid is the factor in blood cell extracts which enhances the ability of CMP-NANA to sialylate gonococcal lipopolysaccharide and induce serum resistance

Autor: Peter D. Redfern, Yuan Gao, Geert-Jans Boons, Philip G. Quirk, Harry Smith, N. J. Parsons, Peter R. Ashton, Jeffrey A. Cole, Jetesh Patel, J. Bramley, Chrystala Constantinidou

Publikováno v: Microbial Pathogenesis. 20:87-100

In previous work, a factor which enhances the ability of cytidine 5'-monophospho-N-acetyl neuraminic acid (CMP-NANA) to sialylate gonococcal lipopolysaccharide (LPS) was liberated at 4 degrees C in diffusates from high M(r) fractions of blood cell so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e88b50afa4943dcc9e199addf4b5fd
https://doi.org/10.1006/mpat.1996.0008

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A serum-sensitive, sialyltransferase-deficient mutant of Neisseria gonorrhoeae defective in conversion to serum resistance by CMP-NANA or blood cell extracts

Autor: J. Bramley, P. Jones, X. Nassif, R Demarco de Hormaeche, J. A. Cole, N. J. Parsons, Chrystala Constantinidou, Harry Smith

Publikováno v: Microbial Pathogenesis. 18:187-195

A stable, sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62 totally defective in CMP-NANA-dependent lipopolysaccharide (LPS) sialylation was isolated by insertion mutagenesis with transposon Tn 1545-delta 3 and screened for unlab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47aa9bd007a0100cd9273d9c106e72d
https://doi.org/10.1016/s0882-4010(95)90040-3

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Identification by mass spectrometry of CMP-NANA in diffusible material released from high Mr blood cell fractions that confers serum resistance on gonococci

Autor: N. J. Parsons, Peter R. Ashton, Chrystala Constantinidou, Jeffrey A. Cole, Harry Smith

Publikováno v: Microbial Pathogenesis. 14:329-335

In previous work, a low M(r) component from human blood which converts serum-sensitive gonococci to resistance was shown to be indistinguishable from cytidine 5'-monophospho-N-acetyl neuraminic acid (CMP-NANA) by seven criteria. However, the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecbbec533277e8bc9fbb6d0afd216b8
https://doi.org/10.1006/mpat.1993.1032

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The surface structure seen on gonococci after treatment with CMP-NANA is due to sialylation of surface lipopolysaccharide previously described as a ‘capsule’

Autor: J. A. Cole, N. J. Parsons, Alan Curry, D.M. Jones, Andrew J. Fox, Harry Smith, Raquel Demarco de Hormaeche

Publikováno v: Microbial Pathogenesis. 11:199-210

Phenotypic serum resistance of gonococci in urethral exudates is due to sialylation of lipopolysaccharide (LPS) by host cytidine 5′-monophospho- N -acetyl neuraminic acid (CMP-NANA). A surface structure was visible on gonococci [strain BS4 (agar)]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006b9d44be71157025bc16b38d416299
https://doi.org/10.1016/0882-4010(91)90050-k

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A surface polysaccharide forms when gonococci are converted to serum resistance by cytidine 5′-monophospho-N-acetyl neuraminic acid

Autor: D.M. Jones, Sylvia Lancaster, Jeffrey A. Cole, Alan Curry, Andrew J. Fox, N. J. Parsons, Harry Smith, Patricia L. Rowland

Publikováno v: FEMS Microbiology Letters. 66:75-80

A serum-susceptible, guinea-pig chamber-passaged, laboratory strain (BS4 (agar)) of Neisseria gonorrhoeae was converted to serum resistance by incubation with cytidine 5-monophospho-N-acetyl neuraminic acid (CMP-NANA) and examined by electron microsc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b467c46c60928f50894d52c04eb851d9
https://doi.org/10.1016/0378-1097(90)90261-n

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In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased: implications regarding lactate stimulation of metabolism

Autor: Jeffrey A. Cole, Nicola Woodcock, Edwin A. Yates, N. J. Parsons, Lihui Gao, Harry Smith

Publikováno v: Scopus-Elsevier
Europe PubMed Central

The reason for stimulation by lactate of metabolism of gonococci growing in a medium containing glucose, which enhances pathogenicity by increasing growth rate, lipopolysaccharide (LPS) synthesis and protein formation, has been investigated. Tricine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b7c792c2857e86de6de9f848e5ac75
https://pubmed.ncbi.nlm.nih.gov/11200544

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Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose

Autor: Alan Curry, Jeffrey A. Cole, Lihui Gao, N. J. Parsons, Harry Smith

Publikováno v: FEMS microbiology letters. 169(2)

Gonococci (strain BS4(agar)), emerging from lag-phase during 1-1.5 h incubation in a medium containing glucose (28 mM) and either 5 microM or 50 microM sodium lactate, show enhanced capacity for their lipopolysaccharide (LPS) to be sialylated by cyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eedffb551405a481333a26e30a9d70c
https://pubmed.ncbi.nlm.nih.gov/9868775

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Lactate enhancement of sialylation of gonococcal lipopolysaccharide and of induction of serum resistance by CMP-NANA is not due to direct activation of the sialyltransferase: metabolic events are involved

Autor: Morris Goldner, N. J. Parsons, Jean-Philippe Emond, Harry Smith, Helen Crooke, J. Bramley, Jeffrey A. Cole

Publikováno v: Microbial pathogenesis. 21(3)

Lactate enhances lipopolysaccharide (LPS) sialylation and induction of serum resistance in gonococci by CMP-NANA. To investigate whether the enhancement is due to a direct effect on the sialyltransferase, an improved extraction of the enzyme and a re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6cc9abb220f887d87ef53d24d6e807
https://pubmed.ncbi.nlm.nih.gov/8878016

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