Zobrazeno 1 - 10
of 70
pro vyhledávání: '"N. J. McHugh"'
Autor:
N J McHugh, Georgina Harvey
Publikováno v:
Current Opinion in Rheumatology. 11:495-502
Recent evidence has confirmed that sera from most systemic sclerosis (SSc) patients contain one of three mutually exclusive, SSc-associated autoantibodies (anti-RNA polymerase III, anti-topoisomerase I, or anti-centromere antibodies). Each is associa
Autor:
W, Tillett, D, Jadon, G, Shaddick, G, Robinson, R, Sengupta, E, Korendowych, C S, de Vries, N J, McHugh
Publikováno v:
Arthritis careresearch. 66(2)
We set out to assess the feasibility, reliability, and sensitivity to change of 4 radiographic scoring methods in psoriatic arthritis (PsA).Hand and feet radiographs from 50 patients with PsA were scored at 2 time points by 2 assessors with each of t
Publikováno v:
British Journal of Dermatology. 135:678-686
The cutaneous lesions in systemic sclerosis (SSc) and lupus erythematosus (LE) are pathologically distinct and may display separate cell adhesion receptors. We have scored lesional skin for the presence of cell adhesion molecules that may influence i
Publikováno v:
Annals of the Rheumatic Diseases. 55:507-512
OBJECTIVE: To describe and quantify the morphological characteristics of nailfold capillaries that distinguish different forms of connective tissue disease from healthy controls. METHODS: A CCD video microscope with fibreoptic illumination and PC bas
Publikováno v:
Arthritis & Rheumatism. 38:1845-1850
Objective. To study the serologic status of 3 previously unreported monozygotic twin pairs discordant for systemic sclerosis (SSc). Methods. Autoantibodies were measured by indirect immunofluorescence, immunodiffusion, and immunoprecipitation of 35S-
Autor:
James J. Champoux, Lance Stewart, N. D. Hall, J Whyte, William C. Earnshaw, Leon H. Parker, N J McHugh
Publikováno v:
Scopus-Elsevier
SUMMARYTopoisomerase I (topo I) is a major systemic sclerosis (SSc)-associated autoantigen. A cDNA construct encoding full length human topo I in a recombinant baculovirus transfer vector was used to infect insect cells in culture from which recombin
Autor:
C. O. Stephens, Ken I. Welsh, N J McHugh, Peter J. Maddison, J Whyte, Georgina Harvey, Carol M. Black, Carol M. Artlett
Publikováno v:
Journal of Autoimmunity. 7:509-520
The frequency and functional properties of anti-topoisomerase-1 antibodies (ATA) have been studied in 58 systemic sclerosis (SSc) probands, 218 first degree relatives and 22 spouses. The dependence of ATA on the presence of certain HLA-DRB1 and HLA-D
Publikováno v:
Rheumatology. 33:834-839
Subgroups of PsA have been described but their relationship to the mode of onset of arthritis, to DIP joint disease and to nail and skin disease remains controversial. Therefore, the pattern of disease was documented in 100 patients with PsA in whom
Autor:
David Briggs, C. O. Stephens, J Whyte, Peter J. Maddison, N. G. Gusseva, Carol M. Artlett, Kenneth I. Welsh, Carol M. Black, Nancy J. Olsen, A. B. Scherbakov, N J McHugh
Publikováno v:
Europe PubMed Central
Families with more than one case of scleroderma are unusual. Four families each with two members (in one case monozygotic twins) with scleroderma (systemic sclerosis, SSc) were identified. Clinical, immunogenetic and autoantibody studies were carried
Publikováno v:
Rheumatology. 33:255-259
Cervical spondylitis has been reported in 35-75% of patients with PsA. The clinical and radiological changes of the cervical spine were evaluated in 75 patients with PsA. Cervical spine involvement was found in 45% of those examined and 36% of patien