Zobrazeno 1 - 10
of 46
pro vyhledávání: '"N. J. Goulding"'
Publikováno v:
Mediators of Inflammation, Vol 8, Iss 1, Pp 53-62 (1999)
Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the prote
Externí odkaz:
https://doaj.org/article/0f9398d88bdf4f3ca3f31a64e55838f7
Publikováno v:
Mediators of Inflammation, Vol 2, Iss 1, Pp 49-52 (1993)
The annexin lipocortin 1 is reported to mediate some anti-inflammatory effects of glucocorticoids, but the mechanisms of this mediation are incompletely understood. The involvement of lipocortin 1 in glucocorticoid inhibition of monocyte interleukin
Externí odkaz:
https://doaj.org/article/5ba593a15b9b49dcba8e822e9305f379
Autor:
N J Goulding
Publikováno v:
Rheumatology. 37:477-480
Potential role of Clara cell protein, an endogenous phospholipase A2 inhibitor, in acute lung injury
Autor:
N J Goulding, Alfred Bernard, W. De Backer, A.G. Herman, Yves Sibille, P. G. Jorens, Robert Lauwerys, R J Flower, F. J. van Overveld, L. Bossaert
Publikováno v:
The European respiratory journal
It is now recognized that epithelial cells lining airways and alveoli are capable of releasing various mediators, which have the potential to modulate local inflammatory reactions. The amount of the 16 kDa Clara cell protein (CC16), an inhibitor of p
Publikováno v:
The Journal of Immunology. 151:4306-4314
The activity of the steroid-inducible protein lipocortin-1 (LC1; with a primary sequence of 346 amino acids; also called annexin 1), a fragment corresponding to amino acids 1-188 and a short peptide from the N-terminus (amino acid 2-26) were tested f
Autor:
N. J. Goulding, Eric F Morand
Publikováno v:
Rheumatology. 32:816-819
Publikováno v:
Journal of Immunological Methods. 131:119-125
The physiological function of the lipocortins, proteins which are thought to be glucocorticoid-regulated, is unclear. An improved assay for lipocortins might help to elucidate their role. A rapid and specific sandwich enzyme-linked immunosorbent assa
Publikováno v:
British journal of pharmacology. 133(2)
Transfection of the pre-monomyelocytic U937 cell line with a plasmid coding for full-length annexin 1 (ANX1, 347 amino acid) leads to cell death by promoting apoptosis. In addition, over-expression of the N-terminal and the first domain of the protei
Autor:
Ivana Aiello, Helen C. Christian, K.G. Mugridge, Mauro Perretti, Samantha K. Wheller, John F. Morris, Roderick J. Flower, N. J. Goulding
Publikováno v:
Cell biology international. 24(3)
Annexin I, a member of the calcium- and phospholipid-binding annexin superfamily of proteins, is largely present in human neutrophils. To determine its exact intracellular distribution a combination of flow cytometry, confocal microscopy and electron
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 47
Neutrophils have been implicated in mediating much of the tissue damage associated with chronic inflammatory diseases such as rheumatoid arthritis, where they are involved in destruction of both cartilage and bone. Glucocorticoids are powerful anti-i