Zobrazeno 1 - 10
of 50
pro vyhledávání: '"N. I. Solov'eva"'
Autor:
N I Solov'eva, O S Ryzhakova
Publikováno v:
Biomeditsinskaya Khimiya. 59:530-540
Matrix metalloproteinases (MMP) play a key role in development of tumor invasion and metestasis. The purpose of the work is the elucidation of peculiarities of expression of MMP-1, MMP-2, MMP-9 and their activity regulators: plasminogen activator uPA
Publikováno v:
Bioorganicheskaia khimiia. 40(6)
A key role in tumor progression play two processes--the destruction and angiogenesis. Matrix metalloproteases (MMPs) play a leading role during tissue degradation. Tissue collagenase--MMP-1 and MT1-MMP hydrolyze fibrillar collagens, which are the bas
Publikováno v:
Bulletin of Experimental Biology and Medicine. 117:593-596
The action of the preparation Digestase on several protein and synthetic substrates is examined, as well as the effect of a number of proteinase inhibitors on this enzyme preparation. Digestase has been found to exhibit considerable trypsinlike and c
Autor:
T A, Moskvitina, N I, Solov'eva
Publikováno v:
Klinicheskaia laboratornaia diagnostika. (1)
The paper describes the physiological effects of various biogenic amines, their occurrence in the body, and degradation. It outlines the present views of diversity of flavin adenine dinucleotide-dependent and semicarbazide-sensitive amine oxidases. M
Autor:
N I, Solov'eva, O S, Ryzhakova
Publikováno v:
Klinicheskaia laboratornaia diagnostika. (2)
The paper describes methods for determining the activity of matrix metalloproteinases (MMP), primarily collagenases and gelatinases, by applying natural protein substrates. Reconstructed fluorescein-labeled type I collagen fibrils were used to determ
Publikováno v:
Biomeditsinskaia khimiia. 55(4)
Matrix metalloproteinases (MMP) play a critical role in tumor invasion and metastasis. The aim of this study was to elucidate peculiarity of expression of gelatinases A and B (MMP-2 and MMP-9), membrane type MMP (MT1-MMP) and tissue inhibitor of MMP
Publikováno v:
Biomeditsinskaia khimiia. 53(3)
Matrix metalloproteinases (MMPs) play a critical role in tumor development and invasion. The aim of this study is to elucidate peculiarity of expression of interstitial collagenase (MMP-1) and its endogenous regulators in the process of oncogenic tra
Autor:
O S, Ryzhakova, N I, Solov'eva
Publikováno v:
Biomeditsinskaia khimiia. 51(4)
This report describes the assay of collagenolytic activity, particularly activity of tissue collagenases, using the reconstituted fibrils of fluorescein-labeled collagen type I as substrate. Labeling of soluble rat skin collagen was carried out by th
Publikováno v:
Voprosy meditsinskoi khimii. 48(6)
The thermostable endogenous cysteine proteinase inhibitors (CPI) from the primary (REF), immortal (clone IE5) and transformed (clones trF8 and trF8nmcc) fibroblasts were isolated. All the isolated CPI act as reversible competitive inhibitors of cathe
Autor:
N I, Solov'eva, S V, Vinokurova, E A, Dilakian, T A, Gureeva, V A, Zhurbitskaia, T O, Balaevskaia
Publikováno v:
Voprosy meditsinskoi khimii. 47(1)
To elucidate the role of matrix metalloproteinases (MMP) in carcinogenesis, the expression of collagenases of types I (MMP-I) and IV (MMP-2 and MMP-9) as well as the behaviour of urokinase-like plasminogen activator (uPA) and of tissue MMP inhibitors