Zobrazeno 1 - 10
of 20
pro vyhledávání: '"N. I. Gutkina"'
Publikováno v:
Сибирский онкологический журнал, Vol 17, Iss 4, Pp 30-35 (2018)
PCR clamping/wild-type blocking PCR with non-extendable locked nucleic acid (LNA) oligonucleotides is used for sensitive detection of somatic mutations in tumors. Various versions of the technique use different DNA polymerases and LNA oligonucleotide
Externí odkaz:
https://doaj.org/article/4c0606961de94c8084c06cd29a8b52a0
Autor:
M. S. Anisimenko, G. A. Paul, A. E. Kozyakov, N. I. Gutkina, D. A. Berdyugina, A. Yu. Garanin, A. V. Butorina, E. V. Gornostaeva, K. F. Khafizov, Yu. V. Vyatkin, D. N. Shtokalo, S. P. Kovalenko
Publikováno v:
Сибирский онкологический журнал, Vol 17, Iss 4, Pp 53-58 (2018)
Aim of the study. Aim of the study was to estimate the occurrence of pathogenic mutations in the BRCA1 gene in Russian breast cancer patients.Material and methods. Complete coding sequence of the BRCA1 gene of 445 early onset breast cancer patients (
Externí odkaz:
https://doaj.org/article/e8f4586fb9f3475097456d7988c4d278
Publikováno v:
Molecular Biology. 46:658-663
The technique for the detection of frame shift and nonsense mutations in BRCA1 gene was suggested. The technique presumes the construction of recombinant plasmids where the tested DNA fragment placed in-frame with alkaline phosphatase gene of Escheri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af560517ca3346ac0ad330127e4f3bcc
https://doi.org/10.1134/s002689331204005x
https://doi.org/10.1134/s002689331204005x
Publikováno v:
Molecular Biology. 46:588-595
The introduction of foreign peptides into alkaline phosphatase that have a minimal influence on the enzymatic activity of a protein is described in the work. Calculated based on the methods of molecular dynamics the longest surface loops of alkaline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d9a760684523af283cac8f12e0a3d31
https://doi.org/10.1134/s0026893312020094
https://doi.org/10.1134/s0026893312020094
Publikováno v:
Molekuliarnaia biologiia. 46(4)
The paper presents the description of the experiments in line with the rational concept for the "safe" insertion of guest polypeptides into the alkaline phosphatase with the minimal influence of the inserts on the enzymatic activity of the protein. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b890b87b6add2860bdf5f569817fa42
https://pubmed.ncbi.nlm.nih.gov/23113355
https://pubmed.ncbi.nlm.nih.gov/23113355
Autor:
V V, Liakhovich, V A, Vavilin, S I, Makarova, S M, Gavalov, O A, Riabova, O B, Chasovnikova, N I, Gutkina
Publikováno v:
Vestnik Rossiiskoi akademii meditsinskikh nauk. (12)
The paper shows the impact of some mutations of CYP1A, GSTM1, GSTT1, and NAT2 genes and different combinations of alleles of these genes on susceptibility to bronchial asthma and its clinical features. Passive smoking modulates these relationships.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d02a50a288cf99a2abcd1c316282826
https://pubmed.ncbi.nlm.nih.gov/11202642
https://pubmed.ncbi.nlm.nih.gov/11202642
Autor:
T G, Duzhak, N I, Gutkina, D V, Mitrofanov, O A, Afanas'eva, O L, Posukh, Iu A, Kriukov, L P, Osipova, V V, Liakhovich
Publikováno v:
Genetika. 34(11)
Data on the first examination of the CYP1A1 and CYP2D6 genes' polymorphism in the populations of Tundra Nentsis (Yamalo-Nenetskii Autonomous District) and migrant population of Western Siberia (Novosibirsk oblast and Altaiskii krai) are presented. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ceccea94860873215d2fba87874eb757
https://pubmed.ncbi.nlm.nih.gov/10096031
https://pubmed.ncbi.nlm.nih.gov/10096031
Publikováno v:
International journal of circumpolar health. 57
The purpose of this study was to establish the frequencies of CYP1A1 and CYP2D6 polymorphic genotypes in the Tundra Nentsi population, which is a small indigenous northern people living in Siberia and belonging to the Northern Mongoloid race. The fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0441a43aa4de489190b66629e2cda44c
https://pubmed.ncbi.nlm.nih.gov/10093378
https://pubmed.ncbi.nlm.nih.gov/10093378
Autor:
V V, Liakhovich, V A, Vavilin, N I, Gutkina, I P, Laktionova, S I, Makarova, D V, Mitrofanov, V A, Ostashevskiĭ, O B, Chasovnikova
Publikováno v:
Voprosy meditsinskoi khimii. 43(5)
The paper presents the results of study on polymorfisms of xenobiotic biotransformation enzymes (CYP1A1, glutathione S-transferase MI and N-acetyltransferase 2) and p53 tumor suppressor protein in patients with lung, stomach and intestine cancer. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdad49322b56781a80c025a438badb8e
https://pubmed.ncbi.nlm.nih.gov/9446323
https://pubmed.ncbi.nlm.nih.gov/9446323
Publikováno v:
Biokhimiia (Moscow, Russia). 55(1)
The induction by triphenyldioxane (TPD) of cytochrome P-450 in rat liver microsomes was studied. It was demonstrated that TPD injection in a single dose (10 mg/kg of body mass) is associated with a marked induction of cytochromes P-450 b/e (cytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9783804a342cb1f680530566cc25bff0
https://pubmed.ncbi.nlm.nih.gov/2344457
https://pubmed.ncbi.nlm.nih.gov/2344457