Zobrazeno 1 - 10 of 206 pro vyhledávání: '"N. Haines"'
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Akademický článek
HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species
Autor: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H. Palacios, Maurie Balch, Macy L. Sprunger, Matthew K. Howard, Jeremy J. Ryan, Jessica N. Haines, Gary J. Patti, Albert A. Davis, Meredith E. Jackrel
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Parkinson’s disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease, and inactivating mutation
Externí odkaz: https://doaj.org/article/d3a814cfc6b44384be88ec4319bf5430
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6
Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer
Autor: Corinne N. Haines, Suzanne E. Wardell, Donald P. McDonnell
Publikováno v: Essays in Biochemistry. 65:985-1001
Nearly 80% of all breast cancers are estrogen receptor positive (ER+) and require the activity of this transcription factor for tumor growth and survival. Thus, endocrine therapies, which target the estrogen signaling axis, have and will continue to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6d7a7ff3f46e6f93b2b60779200d7f
https://doi.org/10.1042/ebc20200174
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7
Akademický článek
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8
GREB1 regulates PI3K/Akt signaling to control hormone-sensitive breast cancer proliferation
Autor: Craig J. Burd, Corinne N Haines, Hope D Klingensmith, Makanko Komara
Publikováno v: Carcinogenesis
Over 70% of breast cancers express the estrogen receptor (ER) and depend on ER activity for survival and proliferation. While hormone therapies that target receptor activity are initially effective, patients invariably develop resistance which is oft
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d5cf82ef9b2c528115b709464bb634
https://doi.org/10.1093/carcin/bgaa096
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9
Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma
Autor: Brent A. Hanks, Debarati Mukherjee, Jonathan Shepherd, Suzanne E. Wardell, Robert Baldi, Wen Liu, Corinne N. Haines, Charles M. Perou, Sandeep Artham, Jovita Byemerwa, Weida Gong, Olivia Brueckner, Binita Chakraborty, Ching-Yi Chang, Yeeun Bae, Donald P. McDonnell, Felicia Lim, Kendall A. Heetderks
Publikováno v: J Clin Invest
Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences in response to ICB have been observed, with males receiving a grea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7193cf9a960764dd33f6d5636a5b5862
https://doi.org/10.1172/jci151347
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10
Structural Perturbations of Rhodopseudomonas palustris Form II RuBisCO Mutant Enzymes That Affect CO2 Fixation
Autor: Annie Shin, Vanessa A. Varaljay, Sidney N Haines, John A. Wildenthal, Sriram Satagopan, Justin A. North, F. Robert Tabita, Kathryn M. Byerly, Mark A. Arbing
Publikováno v: Biochemistry. 58:3880-3892
The enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its central role in capturing atmospheric CO2 via the Calvin-Benson-Bassham (CBB) cycle have been well-studied. Previously, a form II RuBisCO from Rhodopseudomonas palustris, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70e6fb398a3ae4e1923cd55589fb8ffd
https://doi.org/10.1021/acs.biochem.9b00617
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