Zobrazeno 1 - 10
of 135
pro vyhledávání: '"N. Haidar"'
Autor:
Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering
Externí odkaz:
https://doaj.org/article/d2f84672e7fe4eb3b7df368784cf9d36
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Michael Kalos, Dale L. Ludwig, Gregory D. Plowman, Christopher M. Moxham, Ruslan D. Novosiadly, Jaafar N. Haidar, Andreas Sonyi, Darin Chin, Stacy Torgerson, Bing Han, Yanbin Lao, Tim Bailey, Danielle K. Bulaon, Yiwei Zhang, Xinlei Chen, Michael Topper, Sagit Hindi, Krishnadatt Persaud, Anthony L. Pennello, David Surguladze, Ivan Inigo, George Wang, Yang Shen, Scott W. Eastman, Carmine Carpenito, Maria Malabunga, Yiwen Li, Helen Kotanides
The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell–mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1986ead76832948fc92b79c10618c0e0
https://doi.org/10.1158/2326-6066.c.6550090
https://doi.org/10.1158/2326-6066.c.6550090
Autor:
Michael Kalos, Dale L. Ludwig, Gregory D. Plowman, Christopher M. Moxham, Ruslan D. Novosiadly, Jaafar N. Haidar, Andreas Sonyi, Darin Chin, Stacy Torgerson, Bing Han, Yanbin Lao, Tim Bailey, Danielle K. Bulaon, Yiwei Zhang, Xinlei Chen, Michael Topper, Sagit Hindi, Krishnadatt Persaud, Anthony L. Pennello, David Surguladze, Ivan Inigo, George Wang, Yang Shen, Scott W. Eastman, Carmine Carpenito, Maria Malabunga, Yiwen Li, Helen Kotanides
Supplementary Figures 1-9 and Supplementary Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae9b70f08e357e6f6d0737e3afa7b80
https://doi.org/10.1158/2326-6066.22542937.v1
https://doi.org/10.1158/2326-6066.22542937.v1
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Figure S9 shows antitumor efficacy of combination therapy in the L55 NSCLC tumor xenograft model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e0befc3cf257f3da5e314069cd7d7a
https://doi.org/10.1158/1535-7163.22519392.v1
https://doi.org/10.1158/1535-7163.22519392.v1
Autor:
Kathryn M. Ferguson, Ruslan D. Novosiadly, Yang Shen, Amelie Forest, Jason M. Walker, Michelle D. Iacolina, Michael Topper, Michal Vieth, Scott W. Eastman, Jaafar N. Haidar, Atrish Bagchi
Supplementary Table S1 - Therapeutic antibody induced EGFR ECR mutations; Supplementary Table S2 - Mean SPR KD values for binding of wild type (WT) and cetuximab resistance variants of sEGFR to immobilized Fab fragments from cetuximab (FabC225) and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d92447c8e255cf0b039b66a1add238
https://doi.org/10.1158/1535-7163.22510134
https://doi.org/10.1158/1535-7163.22510134
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Table S2 shows human immune effector ADCC and CDC activity EC50 (nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7d8844ae274ecd96486d49338c0e0
https://doi.org/10.1158/1535-7163.22519383
https://doi.org/10.1158/1535-7163.22519383
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20e7787d1efd66b5f6dc06f92584d9f
https://doi.org/10.1158/1535-7163.22519389
https://doi.org/10.1158/1535-7163.22519389
Autor:
Eduardo P. Reis, Joselisa P. Q. de Paiva, Maria C. B. da Silva, Guilherme A. S. Ribeiro, Victor F. Paiva, Lucas Bulgarelli, Henrique M. H. Lee, Paulo V. Santos, Vanessa M. Brito, Lucas T. W. Amaral, Gabriel L. Beraldo, Jorge N. Haidar Filho, Gustavo B. S. Teles, Gilberto Szarf, Tom Pollard, Alistair E. W. Johnson, Leo A. Celi, Edson Amaro
Publikováno v:
Scientific Data. 9
Chest radiographs allow for the meticulous examination of a patient’s chest but demands specialized training for proper interpretation. Automated analysis of medical imaging has become increasingly accessible with the advent of machine learning (ML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c2fd6322b6a320a53ee2175c5f57f3
https://doi.org/10.1038/s41597-022-01608-8
https://doi.org/10.1038/s41597-022-01608-8