Enhanced Survival of Dopaminergic Neuronal Transplants in Hemiparkinsonian Rats by the p53 Inactivator PFT-α

Autor: J. Chou, N. H. Greig, D. Reiner, B. J. Hoffer, Y. Wang M.D., Ph.D.

Publikováno v: Cell Transplantation, Vol 20 (2011)

A key limiting factor impacting the success of cell transplantation for Parkinson's disease is the survival of the grafted cells, which are often short lived. The focus of this study was to examine a novel strategy to optimize the survival of exogeno

Externí odkaz: https://doaj.org/article/f6ba157cda074f379a790a11fd3ff762

Novel 1,2,4-triazole derivatives containing the naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, and biological evaluation.

Autor: Koçak Aslan E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Sıhhiye, Turkey., Sezer A; Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Sıhhiye, Ankara, Turkey., Tüylü Küçükkılınç T; Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Sıhhiye, Ankara, Turkey., Palaska E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Sıhhiye, Turkey.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Nov; Vol. 357 (11), pp. e2400406. Date of Electronic Publication: 2024 Jul 21.

Amyloid and Neurodegeneration: Alzheimer's Disease and Retinal Degeneration

Autor: Anitha Suram, Kumar Sambamurti, Chitra Venugopal, M. A. Pappolla, N. H. Greig, K. A. Sharpe, Y. Zhou, D. K. Lahiri, Bärbel Rohrer, Annamalai Prakasam, Javier Pacheco-Quinto

Publikováno v: Handbook of Neurochemistry and Molecular Neurobiology ISBN: 9780387303437
Handbook of Neurochemistry and Molecular Neurobiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dadb06ba47b1f80ec4edbdb2cb5b134e
https://doi.org/10.1007/978-0-387-30375-8_7

CIM-Immobilized Butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer’s Disease

Autor: BARTOLINI, MANUELA, ANDRISANO, VINCENZA, N. H. Greig

Alzheimer’s Disease (AD) is associated with a progressive decline in the neurotransmitter acetylcholine (ACh) in the forebrain of afflicted subjects. In healthy human brain, butyrylcholinesterase (BChE, EC 3.1.1.8) has prevalently a supportive role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::b6042b30add15f9434f49277c4627df1
http://hdl.handle.net/11585/61314

In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger

Autor: D M, Cerasoli, E M, Griffiths, B P, Doctor, A, Saxena, J M, Fedorko, N H, Greig, Q S, Yu, Y, Huang, H, Wilgus, C N, Karatzas, I, Koplovitz, D E, Lenz

Publikováno v: Chemico-biological interactions.

Previous studies in rodents and nonhuman primates have demonstrated that pretreatment with cholinesterases can provide significant protection against behavioral and lethal effects of nerve agent intoxication. Human butyrylcholinesterase (HuBuChE) pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a72eefdfe509b68cfaac59bb0669b330
https://pubmed.ncbi.nlm.nih.gov/16429486