Zobrazeno 1 - 10
of 63
pro vyhledávání: '"N. Greenhalgh"'
Autor:
Jessica E. Martin, Emma M. Baxter, Jasmine M. Clarkson, Marianne Farish, Richard E. Clutton, Stephen N. Greenhalgh, Rachael Gregson, Dorothy E. F. McKeegan
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Alternatives to carbon dioxide (CO2) stunning for the commercial slaughter of pigs are urgently needed because there is robust evidence that exposing pigs to hypercapnic environments is associated with pain, fear, and distress. Hypobaric hypoxia (via
Externí odkaz:
https://doaj.org/article/14d935f14cad4c5193c399e621e9a170
Autor:
Emma M. Baxter, Dorothy E. F. McKeegan, Marianne Farish, Jill R. Thomson, Richard E. Clutton, Stephen N. Greenhalgh, Rachael Gregson, Jessica E. Martin
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Pigs are commonly stunned pre-slaughter by exposure to carbon dioxide (CO2), but this approach is associated with significant welfare concerns. Hypobaric hypoxia, achieved with gradual decompression (also known as Low Atmospheric Pressure Stunning or
Externí odkaz:
https://doaj.org/article/5509bf6671e8459fbf6026234fae1fb8
Autor:
Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl-pr
Externí odkaz:
https://doaj.org/article/fb7adb2cd6174d5a9c38555ece25def7
Autor:
Jamie R.K. Marland, Mark E. Gray, Camelia Dunare, Ewen O. Blair, Andreas Tsiamis, Paul Sullivan, Eva González-Fernández, Stephen N. Greenhalgh, Rachael Gregson, R. Eddie Clutton, Magdalena M. Parys, Alex Dyson, Mervyn Singer, Ian H. Kunkler, Mark A. Potter, Srinjoy Mitra, Jonathan G. Terry, Stewart Smith, Andrew R. Mount, Ian Underwood, Anthony J. Walton, David J. Argyle, Alan F. Murray
Publikováno v:
Sensing and Bio-Sensing Research, Vol 30, Iss , Pp 100375- (2020)
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor
Externí odkaz:
https://doaj.org/article/4d575ed143ff4ab788ad2253711af3ac
Autor:
I. R. Murray, Z. N. Gonzalez, J. Baily, R. Dobie, R. J. Wallace, A. C. Mackinnon, J. R. Smith, S. N. Greenhalgh, A. I. Thompson, K. P. Conroy, D. W. Griggs, P. G. Ruminski, G. A. Gray, M. Singh, M. A. Campbell, T. J. Kendall, J. Dai, Y. Li, J. P. Iredale, H. Simpson, J. Huard, B. Péault, N. C. Henderson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The mechanisms underlying tissue fibrosis are unclear. The authors show that mesenchymal cells expressing PDGFRβ mediate fibrosis in skeletal muscle and heart via a mechanism involving αv integrin, and that inhibitors of αv integrins attenuate fib
Externí odkaz:
https://doaj.org/article/8d98304aaf1746329d6b32e5bc823995
Autor:
Mark E. Gray, Paul Sullivan, Jamie R. K. Marland, Stephen N. Greenhalgh, James Meehan, Rachael Gregson, R. Eddie Clutton, Chris Cousens, David J. Griffiths, Alan Murray, David Argyle
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
In vitro cell line and in vivo murine models have historically dominated pre-clinical cancer research. These models can be expensive and time consuming and lead to only a small percentage of anti-cancer drugs gaining a license for human use. Large an
Externí odkaz:
https://doaj.org/article/3ecff992c3ba4e9a98691efa22d5a1fe
Autor:
Mark E. Gray, James Meehan, Paul Sullivan, Jamie R. K. Marland, Stephen N. Greenhalgh, Rachael Gregson, Richard Eddie Clutton, Carol Ward, Chris Cousens, David J. Griffiths, Alan Murray, David Argyle
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Lung cancer represents a major worldwide health concern; although advances in patient management have improved outcomes for some patients, overall 5-year survival rates are only around 15%. In vitro studies and mouse models are commonly used to study
Externí odkaz:
https://doaj.org/article/cc0fd80d0a444c4d856cc13f6fba9c2d
Publikováno v:
Laboratory Animals
Gregson, R, Greenhalgh, S, Cox, B, Cochrane, S & Clutton, E 2020, ' Feeding management before gastrointestinal studies in pigs ', Laboratory Animals . https://doi.org/10.1177/0023677220960509
Gregson, R, Greenhalgh, S, Cox, B, Cochrane, S & Clutton, E 2020, ' Feeding management before gastrointestinal studies in pigs ', Laboratory Animals . https://doi.org/10.1177/0023677220960509
Pigs are used to model humans in gastrointestinal (GI) studies because of their comparable size, physiology and behaviour: both are monogastric omnivores. A porcine surgical model for testing novel, tethered ultrasound capsule endoscopes (USCE) requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed50490a7879e6195896e768e08114bf
https://doi.org/10.1177/0023677220960509
https://doi.org/10.1177/0023677220960509
Autor:
Ahmet Ucar, Stewart Smith, Jamie R. K. Marland, Matteo Staderini, Ewen O. Blair, Paul Sullivan, R. E. Clutton, Eva González-Fernández, Mark Gray, Mark Bradley, Andreas Tsiamis, David J. Argyle, Jonathan G. Terry, Alan F. Murray, Stephen N. Greenhalgh, Camelia Dunare, Anthony J. Walton, Rachael Gregson, Andrew R. Mount
Publikováno v:
González-fernández, E, Staderini, M, Marland, J R K, Gray, M E, Uçar, A, Dunare, C, Blair, E O, Sullivan, P, Tsiamis, A, Greenhalgh, S N, Gregson, R, Clutton, R E, Smith, S, Terry, J G, Argyle, D J, Walton, A J, Mount, A R, Bradley, M & Murray, A F 2021, ' In vivo application of an implantable tri-anchored methylene blue-based electrochemical pH sensor ', Biosensors and Bioelectronics, pp. 113728 . https://doi.org/10.1016/j.bios.2021.113728
The development of robust implantable sensors is important in the successful advancement of personalised medicine as they have the potential to provide in situ real-time data regarding the status of health and disease and the effectiveness of treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4721ccc36575ae47ef2e80bbacb0484e
https://hdl.handle.net/20.500.11820/d2ed2ab0-e2ce-4cca-81e9-e1f267bfb8f4
https://hdl.handle.net/20.500.11820/d2ed2ab0-e2ce-4cca-81e9-e1f267bfb8f4
Autor:
Andreas Tsiamis, Camelia Dunare, Alex Dyson, Jamie R. K. Marland, Ewen O. Blair, Alan F. Murray, Rachael Gregson, Andrew R. Mount, Magdalena M Parys, Stewart Smith, R Eddie Clutton, Ian H. Kunkler, Anthony J. Walton, Mark A Potter, Stephen N. Greenhalgh, Mark Gray, Ian Underwood, Srinjoy Mitra, Paul Sullivan, David Argyle, Mervyn Singer, Jonathan G. Terry, Eva González-Fernández
Publikováno v:
Marland, J, Gray, M, Dunare, C, Blair, E, Tsiamis, A, Sullivan, P, González-Fernández, E, Greenhalgh, S, Gregson, R, Clutton, E, Parys, M, Dyson, A, Singer, M, Kunkler, I, Potter, M A, Mitra, S, Terry, J, Smith, S, Mount, A, Underwood, I, Walton, A, Argyle, D & Murray, A 2020, ' Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor ', Sensing and Bio-Sensing Research, vol. 30, 100375, pp. 1-12 . https://doi.org/10.1016/j.sbsr.2020.100375
Sensing and Bio-Sensing Research, Vol 30, Iss, Pp 100375-(2020)
Sensing and Bio-Sensing Research
Sensing and Bio-Sensing Research, Vol 30, Iss, Pp 100375-(2020)
Sensing and Bio-Sensing Research
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610c5eea425894e8d1edc2edcbde5ec8
https://doi.org/10.1016/j.sbsr.2020.100375
https://doi.org/10.1016/j.sbsr.2020.100375