Zobrazeno 1 - 10
of 146
pro vyhledávání: '"N. Ghadiali"'
Autor:
Christopher M. Bobba, Qinqin Fei, Vasudha Shukla, Hyunwook Lee, Pragi Patel, Rachel K. Putman, Carleen Spitzer, MuChun Tsai, Mark D. Wewers, Robert J. Lee, John W. Christman, Megan N. Ballinger, Samir N. Ghadiali, Joshua A. Englert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological leve
Externí odkaz:
https://doaj.org/article/d590e28056334e1c821dbc94a711313f
Autor:
Hyunwook Lee, Qinqin Fei, Adam Streicher, Wenjuan Zhang, Colleen Isabelle, Pragi Patel, Hilaire C. Lam, Antonio Arciniegas-Rubio, Miguel Pinilla-Vera, Diana P. Amador-Munoz, Diana Barragan-Bradford, Angelica Higuera-Moreno, Rachel K. Putman, Lynette M. Sholl, Elizabeth P. Henske, Christopher M. Bobba, Natalia Higuita-Castro, Emily M. Shalosky, R. Duncan Hite, John W. Christman, Samir N. Ghadiali, Rebecca M. Baron, Joshua A. Englert
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
The acute respiratory distress syndrome (ARDS) is a highly lethal condition that impairs lung function and causes respiratory failure. Mechanical ventilation (MV) maintains gas exchange in patients with ARDS but exposes lung cells to physical forces
Externí odkaz:
https://doaj.org/article/046048147d16480695cff473141c80c1
Autor:
Caitlin E. Jones, Anisha M. Hammer, YouJin Cho, Gina M. Sizemore, Edna Cukierman, Lisa D. Yee, Samir N. Ghadiali, Michael C. Ostrowski, Jennifer L. Leight
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 132-145 (2019)
The organization of the extracellular matrix has a profound impact on cancer development and progression. The matrix becomes aligned throughout tumor progression, providing “highways” for tumor cell invasion. Aligned matrix is associated with bre
Externí odkaz:
https://doaj.org/article/fb890cfa8be04e6385066d38ace09c7d
Autor:
Caymen M. Novak, Shruthi Sethuraman, Kristina L. Luikart, Brenda F. Reader, Jana S. Wheat, Bryan Whitson, Samir N. Ghadiali, Megan N. Ballinger
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L507-L520
Idiopathic pulmonary fibrosis (IPF) is characterized by increased collagen accumulation that is progressive and nonresolving. Although fibrosis progression may be regulated by fibroblasts and alveolar macrophage (AM) interactions, this cellular inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef13fc41df1cd3801cdce4c15ac1639b
https://doi.org/10.1152/ajplung.00263.2022
https://doi.org/10.1152/ajplung.00263.2022
Autor:
Caitlin E Jones, Joe T Sharick, Sheila E Colbert, Vasudha C Shukla, Joshua M Zent, Michael C Ostrowski, Samir N Ghadiali, Steven T Sizemore, Jennifer L Leight
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245653 (2021)
Collagen deposition contributes to both high mammographic density and breast cancer progression. Low stromal PTEN expression has been observed in as many as half of breast tumors and is associated with increases in collagen deposition, however the me
Externí odkaz:
https://doaj.org/article/9f9da990094543c491980f3fcf8a6c82
Autor:
Anisha M. Hammer, Gina M. Sizemore, Vasudha C. Shukla, Alex Avendano, Steven T. Sizemore, Jonathan J. Chang, Raleigh D. Kladney, Maria C. Cuitiño, Katie A. Thies, Quinn Verfurth, Arnab Chakravarti, Lisa D. Yee, Gustavo Leone, Jonathan W. Song, Samir N. Ghadiali, Michael C. Ostrowski
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 6, Pp 496-508 (2017)
The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth fac
Externí odkaz:
https://doaj.org/article/e1399869f2b04546b0a7627580e40856
Autor:
Richard S. Nho, Megan N. Ballinger, Mauricio M. Rojas, Samir N. Ghadiali, Jeffrey C. Horowitz
Publikováno v:
Am J Pathol
Lung fibrosis is characterized by the continuous accumulation of extracellular matrix (ECM) proteins produced by apoptosis-resistant (myo)fibroblasts. Lung epithelial injury promotes the recruitment and activation of fibroblasts, which are necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8763c3d91855691fb8713ab024d0e3c
https://doi.org/10.1016/j.ajpath.2022.02.001
https://doi.org/10.1016/j.ajpath.2022.02.001
Autor:
Qinqin Fei, Emily M. Shalosky, Ryelie Barnes, Vasudha C. Shukla, Megan N. Ballinger, Laszlo Farkas, Robert J. Lee, Samir N. Ghadiali, Joshua A. Englert
Publikováno v:
bioRxiv
The pro-inflammatory response of alveolar macrophages to injurious physical forces during mechanical ventilation is regulated by the anti-inflammatory microRNA, miR-146a. Increasing miR-146a expression to supraphysiologic levels using untargeted lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cf87f9ac593e4cf2175e4122462748
https://europepmc.org/articles/PMC9949132/
https://europepmc.org/articles/PMC9949132/
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 79:102196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcef45e6b62e3456ee9b7a4596801f95
https://doi.org/10.1016/j.pupt.2023.102196
https://doi.org/10.1016/j.pupt.2023.102196
Autor:
Carleen R. Spitzer, Robert J. Lee, Rachel K. Putman, Mark D. Wewers, Joshua A. Englert, MuChun Tsai, John W. Christman, Vasudha C. Shukla, Qinqin Fei, Hyunwook Lee, Megan N. Ballinger, Samir N. Ghadiali, Christopher M Bobba, Pragi Patel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Mechanical ventilation generates injurious forces that exacerbate lung injury. These forces disrupt lung barrier integrity, trigger proinflammatory mediator release, and differentially regulate genes and non-coding oligonucleotides including microRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f6972beeb89a8d35b73ca6a3a0d3c6
https://doaj.org/article/d590e28056334e1c821dbc94a711313f
https://doaj.org/article/d590e28056334e1c821dbc94a711313f