Zobrazeno 1 - 9
of 9
pro vyhledávání: '"N. G. Theodorakis"'
Publikováno v:
Molecular and Cellular Biology. 14:4076-4086
The steady-state level of alpha- and beta-tubulin synthesis is autoregulated by a posttranscriptional mechanism that selectively alters alpha- and beta-tubulin mRNA levels in response to changes in the unassembled tubulin subunit concentration. For b
Autor:
N. G. Theodorakis, Don W. Cleveland
Publikováno v:
Molecular and Cellular Biology. 12:791-799
Tubulin synthesis is controlled by an autoregulatory mechanism through which an increase in the intracellular concentration of tubulin subunits leads to specific degradation of tubulin mRNAs. The sequence necessary and sufficient for the selective de
Publikováno v:
Nucleic acids research. 22(2)
The 3'-untranslated regions of many labile transcripts contain AU-rich sequences that serve as cis determinants of mRNA stability and translational efficiency. Using a photocrosslinking technique, our laboratory has previously defined three cytoplasm
Publikováno v:
Molecular and Cellular Biology. 9:3166-3173
Hemin-induced differentiation of the human erythroleukemia cell line K562 results in the expression and accumulation of erythroid-specific gene products such as embryonic and fetal hemoglobins and the elevated synthesis of the major heat shock protei
Publikováno v:
Journal of Biological Chemistry. 263:14579-14585
During heat shock of chicken reticulocytes the synthesis of a single heat shock protein, HSP70, increases greater than 10-fold, while the level of HSP70 mRNA increases less than 2-fold during the same period. Comparison of the in vivo levels of HSP70
Publikováno v:
Carcinogenesis. 9:1733-1738
We investigated the induction of a stress response gene by anticancer drugs that damage and covalently modify DNA and other cellular macromolecules. Two human colon adenocarcinoma cell lines (HT-29 and BE) which differ in sensitivity to chloroethylni
Publikováno v:
Molecular and Cellular Biology. 8:4736-4744
Activation of human heat shock gene transcription by heat shock, heavy metal ions, and amino acid analogs required the heat shock element (HSE) in the HSP70 promoter. Both heat shock- and metal ion-induced HSP70 gene transcription occurred independen
Publikováno v:
Molecular and Cellular Biology. 4:2437-2448
Incubation of chicken reticulocytes at elevated temperatures (43 to 45 degrees C) resulted in a rapid change in the pattern of protein synthesis, characterized by the decreased synthesis of normal proteins, e.g., alpha and beta globin, and the prefer
Publikováno v:
The Journal of biological chemistry. 263(28)
During heat shock of chicken reticulocytes the synthesis of a single heat shock protein, HSP70, increases greater than 10-fold, while the level of HSP70 mRNA increases less than 2-fold during the same period. Comparison of the in vivo levels of HSP70