Výsledky vyhledávání - "N. G. Neville"

Randomized phase II trial with an uPA inhibitor (WX-671) in patients with locally advanced nonmetastatic pancreatic cancer

Autor: P. Bevan, V. Heinemann, C. Mala, N. G. Neville, Matthias P. Ebert, T. Pinter

Publikováno v: Journal of Clinical Oncology. 28:4060-4060

4060 Background: WX-671 (Mesupron) is an orally available prodrug of WX-UK1, a serine protease inhibitor that inhibits uPA as well as other serine proteases. WX-UK1 (Setyono-Han et al., Thromb Haem...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abb1af680b8a520d1dc3c835fdaf822f
https://doi.org/10.1200/jco.2010.28.15_suppl.4060

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A phase I, first-in-human single ascending dose study of the MEK inhibitor WX-554 given to healthy male subjects

Autor: M. Buergle, N. G. Neville, C. Mala, W. A. Schmalix, E. Haindl, P. Bevan

Publikováno v: Journal of Clinical Oncology. 28:e13666-e13666

e13666 Background: WX-554 is a small molecule inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2). The Ras/Raf/MEK/ERK pathway is one of the major signal transduction pathwa...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb1d484d7914e42eae67c87d56a02aa
https://doi.org/10.1200/jco.2010.28.15_suppl.e13666

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A Phase I pharmacokinetic (PK) study of single dose oral therapy with a uPA inhibitor (WX-671)

Autor: N. G. Neville, P. Bevan, M. Buergle, C. Mala, W. A. Schmalix

Publikováno v: Journal of Clinical Oncology. 24:13091-13091

13091 Background: WX-671 is an orally available prodrug of WX-UK1, a serine protease inhibitor that inhibits uPA as well as other serine proteases. WX-UK1 (Setyono-Han et al., Thromb Haemost 2005) and WX-671 have shown to efficiently reduce primary t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd34e85b903820ce8130418752d96f74
https://doi.org/10.1200/jco.2006.24.18_suppl.13091

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