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pro vyhledávání: '"N. G. Denman"'
Publikováno v:
Computational Statistics & Data Analysis. 55:1509-1520
Optimal design for generalized linear models has primarily focused on univariate data. Often experiments are performed that have multiple dependent responses described by regression type models, and it is of interest and of value to design the experi
Publikováno v:
Clinical pharmacology and therapeutics. 82(1)
Generally, information required for approval of new drugs is dichotomous in that the drug is either efficacious and safe or not. Consequently, the purpose of most confirmatory clinical trials is to test the null hypothesis. The primary reasons for de