Zobrazeno 1 - 10 of 177 pro vyhledávání: '"N. F. Olivieri"'
1
Iron-balance and dose-response studies of the oral iron chelator 1,2- dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease
Autor: A F, Collins, F F, Fassos, S, Stobie, N, Lewis, D, Shaw, M, Fry, D M, Templeton, R A, McClelland, G, Koren, N F, Olivieri
Publikováno v: Blood. 83:2329-2333
Several life-threatening complications of the common disorder sickle cell disease require management with red blood cell transfusions and, hence, long-term iron-chelating therapy. The efficacy of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e6f779446ea90dd8643d264bb96a75
https://doi.org/10.1182/blood.v83.8.2329.bloodjournal8382329
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2
Influence of steel factor on hemoglobin synthesis in sickle cell disease
Autor: B A, Miller, S P, Perrine, A, Bernstein, S D, Lyman, D E, Williams, L L, Bell, N F, Olivieri
Publikováno v: Blood. 79:1861-1868
A new hematopoietic growth factor (Steel factor) has been identified which stimulates erythroid proliferation both in vitro and in vivo. We evaluated the influence of recombinant Steel factor on hemoglobin synthesis in peripheral blood (PB) BFU-E-der
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd0810f3e291a61f76c0e161c1197f6
https://doi.org/10.1182/blood.v79.7.1861.bloodjournal7971861
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4
Expression of SCL is normal in transfusion-dependent Diamond-Blackfan anemia but other bHLH proteins are deficient
Autor: M Y, Zhang, G A, Clawson, N F, Olivieri, L L, Bell, C G, Begley, B A, Miller
Publikováno v: Blood. 90(5)
Basic helix-loop-helix proteins, which are tissue specific (SCL) or broadly expressed (E proteins), interact positively to regulate erythroid specific genes. Here, expression of SCL and two broadly expressed E proteins, E47 and HEB, was high early in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf5182da79841d8a4cf2ff0f05389acc
https://pubmed.ncbi.nlm.nih.gov/9292545
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5
Iron-chelating therapy and the treatment of thalassemia
Autor: N F, Olivieri, G M, Brittenham
Publikováno v: Blood. 89(3)
Iron-chelating therapy with deferoxamine in patients with thalassemia major has dramatically altered the prognosis of this previously fatal disease. The successes achieved with deferoxamine, as well as the limitations of this treatment, have stimulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25fa35a1f468185e896fe82f8e6b73ea
https://pubmed.ncbi.nlm.nih.gov/9226195
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6
The pharmacokinetics and pharmacodynamics of the oral iron chelator deferiprone (L1) in relation to hemoglobin levels
Autor: F F, Fassos, J, Klein, D, Fernandes, D, Matsui, N F, Olivieri, G, Koren
Publikováno v: International journal of clinical pharmacology and therapeutics. 34(7)
Recently, we demonstrated that administration of the orally active iron chelating agent deferiprone (1,2-dimethyl-3-hydroxypyrid-4-one (L1)) at 6-hour intervals results in significantly greater urinary iron excretion than that induced during administ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fd873d80c96bb5470d1ec941bc08a5f
https://pubmed.ncbi.nlm.nih.gov/8832304
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8
Identification of a novel beta O-thalassaemia mutation in a Greek family and subsequent prenatal diagnosis
Autor: J S, Waye, B, Eng, N F, Olivieri, D H, Chui
Publikováno v: Prenatal diagnosis. 14(10)
We present a case in which a Greek couple was considered not to be at risk of having children with homozygous beta-thalassaemia, an assessment based largely on the father's belief that he carried alpha-thalassaemia. After their first child was diagno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92fcb40c6bdd104a6507249b5dbdba37
https://pubmed.ncbi.nlm.nih.gov/7899267
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9
DNA diagnosis of Hb S and Hb Caribbean (alpha 2 beta 2 91 Leu--Arg) in a Jamaican family
Autor: J S, Waye, M, Patterson, B, Eng, D H, Chui, G D, Sher, N F, Olivieri
Publikováno v: American journal of hematology. 47(1)
We describe a Canadian infant of Jamaican descent who presented with mild anemia. Hb electrophoresis revealed Hb S and an unknown Hb variant that migrated slightly faster than Hb S on cellulose acetate. Molecular studies of the family indicated that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ef12a0d16f00c972dd8c39301490772
https://pubmed.ncbi.nlm.nih.gov/8042613
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10
Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron
Autor: E W, Randell, J G, Parkes, N F, Olivieri, D M, Templeton
Publikováno v: The Journal of biological chemistry. 269(23)
Non-transferrin-bound iron (NTBI) uptake occurs in a variety of cells by a saturable, specific and temperature-sensitive process. Our previous studies indicated that NTBI uptake by cardiac myocytes and Hep G2 cells was reversibly up-regulated by iron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbab2559aee948bf1e3d671f98fdbfc5
https://pubmed.ncbi.nlm.nih.gov/8206903
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