Výsledky vyhledávání

Equid herpesvirus 1 infection of endothelial cells requires activation of putative adhesion molecules: an in vitro model

Autor: A.S. Hamblin, N. Edington, D. J. Smith

Publikováno v: Clinical and Experimental Immunology. 129:281-287

SUMMARY Antisera to activated equine endothelial cells, which detected surface molecules of 116 kD, 97 kD, 42 kD and 38 kD, were made to investigate the role of endothelial adhesion molecules in equid herpes virus 1 infection. These putative adhesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb89a4ae7edc3791399e77553ea1aa8
https://doi.org/10.1046/j.1365-2249.2002.01463.x

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Equid herpesvirus 1 is neurotropic in mice, but latency from which infectious virus can be reactivated does not occur

Autor: J. Iqbal, N. Edington

Publikováno v: Acta Veterinaria Hungarica. 50:117-129

Equid herpesvirus 1 (EHV-1) is the most common cause of virus-induced abortion in horses. After primary infection the virus becomes latent predominantly in the respiratory tract lymph nodes and the genome can also be detected in the peripheral nervou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc33e69c30b22e496ee3d1f4f5e5513b
https://doi.org/10.1556/avet.50.2002.1.14

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EHV-1 gene63 is not essential for in vivo replication in horses and mice, nor does it affect reactivation in the horse: Short Communication

Autor: J. Iqbal, A Purewal, N. Edington

Publikováno v: Acta Veterinaria Hungarica. 49:473-478

The aim of this study was to investigate the role of immediate early gene (gene63) in the pathogenesis of equine herpesvirus 1 (EHV-1) acute and latent infections in equine and murine models. EHV-1 gene63 mutant virus (g63mut) along with EHV-1 (Ab4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4f37b1d4b45be4024af4e80399831a
https://doi.org/10.1556/004.49.2001.4.11

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Equid herpesvirus 1: platelets and alveolar macrophages are potential sources of activated TGF-B1 in the horse

Autor: N. Edington, P.M Chesters, A Hughes

Publikováno v: Veterinary Immunology and Immunopathology. 75:71-79

Cell mediated responses to Equid herpesvirus 1 (EHV-1) are of short duration in vivo and require considerable expansion to be detected in vitro. Raised serum levels of active transforming growth factor B (TGF-B1) have been shown to depress proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a155e7ab637f2b03d303dee68b7fadb6
https://doi.org/10.1016/s0165-2427(00)00187-2

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Clusterin in Bovine Spongiform Encephalopathy (BSE)

Autor: Gerald A. H. Wells, J. Bee, S. McHattie, N. Edington

Publikováno v: Journal of Comparative Pathology. 121:159-171

Clusterin mRNA, detected in increased quantities in the cervical spinal cord of cattle with bovine spongiform encephalopathy (BSE), was localized mainly in the neuroglia (including astrocytes) of the lateral and ventral areas of white matter. Axonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6601dd8068653b5290f5f7026bdc8d
https://doi.org/10.1053/jcpa.1999.0313

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Clusterin Prevents Aggregation of Neuropeptide 106-126 in Vitro

Autor: N Edington, S McHattie

Publikováno v: Biochemical and Biophysical Research Communications. 259:336-340

The prion/amyloid neuropeptide 106-126 spontaneously aggregates to form fibrillar structures in vitro. The aggregation in vitro could be prevented in a dose-related manner by clusterin, and the specificity of this action was confirmed by reversal wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd46428d5e9aa5a8e946f97ce9ce2ba4
https://doi.org/10.1006/bbrc.1999.0781

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Spectroscopic Probe of Free Volume Changes at Freezing: Raman Scattering fromCS2in Cyclohexane

Autor: Jason Crain, Wilson C. K. Poon, H Vass, D W N Edington, P R L Markwick

Publikováno v: Physical Review Letters. 82:3827-3830

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45105391b3f921cd1ee07150d72fbbf7
https://doi.org/10.1103/physrevlett.82.3827

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In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin

Autor: A S Hamblin, N. Edington, A Purewal, J Iqbal, D. J. Smith

Publikováno v: Journal of General Virology. 79:2997-3004

IL-2 and equine chorionic gonadotrophin (eCG) initiated reactivation of equid herpesvirus-1 (EHV-1) from venous lymphocytes at a frequency of 1/10(-5). Indirect immunofluorescence showed that > 80% of virus-positive leukocytes were CD5+/CD8+ with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bdbdc720240e49c387e8754fe6a858
https://doi.org/10.1099/0022-1317-79-12-2997

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The equid herpesvirus-1 gene 63 is expressed as a leaky late (γ 1) transcript and is nonessential for replication in vitro

Autor: J. Iqbal, A Purewal, N. Edington

Publikováno v: Virus Research. 54:189-195

The regulation of Equid herpesvirus-1 (EHV-1) gene 63 was investigated using molecular expression studies and its role in viral growth was identified by constructing a gene 63 mutant virus. Metabolic inhibitors were used to show that EHV-1 gene 63 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c23733ff6aa6229870a45410c5a4e6a
https://doi.org/10.1016/s0168-1702(98)00005-7

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