Zobrazeno 1 - 10 of 299 pro vyhledávání: '"N. Edington"'
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Detection of latency-associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia
Autor: R Allsop, A Purewal, N. Edington, P M Chesters
Publikováno v: Journal of Virology. 71:3437-3443
Results from Southern hybridization and PCR amplification experiments using a randomly synthesized reverse transcription-PCR product showed that peripheral blood leukocytes from horses showing no clinical signs of disease expressed a putative latency
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d8a0be9146447bb12d13a3c7ba1a7
https://doi.org/10.1128/jvi.71.5.3437-3443.1997
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3
Equid herpesvirus 1 infection of endothelial cells requires activation of putative adhesion molecules: an in vitro model
Autor: A.S. Hamblin, N. Edington, D. J. Smith
Publikováno v: Clinical and Experimental Immunology. 129:281-287
SUMMARY Antisera to activated equine endothelial cells, which detected surface molecules of 116 kD, 97 kD, 42 kD and 38 kD, were made to investigate the role of endothelial adhesion molecules in equid herpes virus 1 infection. These putative adhesion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb89a4ae7edc3791399e77553ea1aa8
https://doi.org/10.1046/j.1365-2249.2002.01463.x
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4
Equid herpesvirus 1 is neurotropic in mice, but latency from which infectious virus can be reactivated does not occur
Autor: J. Iqbal, N. Edington
Publikováno v: Acta Veterinaria Hungarica. 50:117-129
Equid herpesvirus 1 (EHV-1) is the most common cause of virus-induced abortion in horses. After primary infection the virus becomes latent predominantly in the respiratory tract lymph nodes and the genome can also be detected in the peripheral nervou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc33e69c30b22e496ee3d1f4f5e5513b
https://doi.org/10.1556/avet.50.2002.1.14
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5
EHV-1 gene63 is not essential for in vivo replication in horses and mice, nor does it affect reactivation in the horse: Short Communication
Autor: J. Iqbal, A Purewal, N. Edington
Publikováno v: Acta Veterinaria Hungarica. 49:473-478
The aim of this study was to investigate the role of immediate early gene (gene63) in the pathogenesis of equine herpesvirus 1 (EHV-1) acute and latent infections in equine and murine models. EHV-1 gene63 mutant virus (g63mut) along with EHV-1 (Ab4)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4f37b1d4b45be4024af4e80399831a
https://doi.org/10.1556/004.49.2001.4.11
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6
Equid herpesvirus 1: platelets and alveolar macrophages are potential sources of activated TGF-B1 in the horse
Autor: N. Edington, P.M Chesters, A Hughes
Publikováno v: Veterinary Immunology and Immunopathology. 75:71-79
Cell mediated responses to Equid herpesvirus 1 (EHV-1) are of short duration in vivo and require considerable expansion to be detected in vitro. Raised serum levels of active transforming growth factor B (TGF-B1) have been shown to depress proliferat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a155e7ab637f2b03d303dee68b7fadb6
https://doi.org/10.1016/s0165-2427(00)00187-2
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7
Clusterin in Bovine Spongiform Encephalopathy (BSE)
Autor: Gerald A. H. Wells, J. Bee, S. McHattie, N. Edington
Publikováno v: Journal of Comparative Pathology. 121:159-171
Clusterin mRNA, detected in increased quantities in the cervical spinal cord of cattle with bovine spongiform encephalopathy (BSE), was localized mainly in the neuroglia (including astrocytes) of the lateral and ventral areas of white matter. Axonal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6601dd8068653b5290f5f7026bdc8d
https://doi.org/10.1053/jcpa.1999.0313
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8
Clusterin Prevents Aggregation of Neuropeptide 106-126 in Vitro
Autor: N Edington, S McHattie
Publikováno v: Biochemical and Biophysical Research Communications. 259:336-340
The prion/amyloid neuropeptide 106-126 spontaneously aggregates to form fibrillar structures in vitro. The aggregation in vitro could be prevented in a dose-related manner by clusterin, and the specificity of this action was confirmed by reversal wit
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https://doi.org/10.1006/bbrc.1999.0781
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10
In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin
Autor: A S Hamblin, N. Edington, A Purewal, J Iqbal, D. J. Smith
Publikováno v: Journal of General Virology. 79:2997-3004
IL-2 and equine chorionic gonadotrophin (eCG) initiated reactivation of equid herpesvirus-1 (EHV-1) from venous lymphocytes at a frequency of 1/10(-5). Indirect immunofluorescence showed that > 80% of virus-positive leukocytes were CD5+/CD8+ with the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bdbdc720240e49c387e8754fe6a858
https://doi.org/10.1099/0022-1317-79-12-2997
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