Výsledky vyhledávání

Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia

Autor: D F, Jelinek, R C, Tschumper, S M, Geyer, N D, Bone, G W, Dewald, C A, Hanson, M J, Stenson, T E, Witzig, A, Tefferi, N E, Kay

Publikováno v: British journal of haematology. 115(4)

Recent reports suggest that the expression of germline (GL) Ig variable region heavy-chain genes (VH) is a negative prognostic factor for B-cell chronic lymphocytic leukaemia (B-CLL) patients and that CLL B-cell CD38 expression may be a surrogate mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62f1f38efcaf918141eb6f75b1121e42
https://pubmed.ncbi.nlm.nih.gov/11843819

Zobrazit plný text záznamu

Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: impact on clonal B-cell apoptosis

Autor: N E, Kay, L, Han, N, Bone, G, Williams

Publikováno v: British journal of haematology. 112(3)

B-chronic lymphocytic leukaemia (CLL) clonal B cells are characterized by resistance to apoptosis. We evaluated clonal B cells and blood T cells for interleukin 4 (IL-4) content as IL-4 is able to increase CLL cell resistance to apoptosis. The conten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cebb7faa33411a2412344083c7e3ab2
https://pubmed.ncbi.nlm.nih.gov/11260081

Zobrazit plný text záznamu

Prognostic value of serum markers of bone metabolism in untreated multiple myeloma patients

Autor: R, Fonseca, M C, Trendle, T, Leong, R A, Kyle, M M, Oken, N E, Kay, B, Van Ness, P R, Greipp

Publikováno v: British journal of haematology. 109(1)

Bone involvement is a central feature of multiple myeloma (MM). We investigated whether serum markers of osteoblastic and osteoclastic activity correlate with the presence of bone disease and survival in 313 MM patients enrolled in a phase III trial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2144549e9e7ffcda41ef17539d66c5b2
https://pubmed.ncbi.nlm.nih.gov/10848778

Zobrazit plný text záznamu

Activation of human peripheral blood T cells does not lead to increased P-glycoprotein expression

Autor: X Y, Mu, M P, Gosland, M M, Bartik, J, Schimmelpfennig, N E, Kay

Publikováno v: Journal of clinical immunology. 19(4)

The expression of P-glycoprotein (Pgp) on normal human lymphocytes, and its drug exclusion capacity, implies that Pgp might be involved in cytokine secretion. We used two-color flow cytometry to detect simultaneously Pgp expression and IL-2 accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1a8d3fc70145fce5a5c93280b72178e
https://pubmed.ncbi.nlm.nih.gov/10471978

Zobrazit plný text záznamu

T-helper phenotypes in the blood of myeloma patients on ECOG phase III trials E9486/E3A93

Autor: N E, Kay, T, Leong, N, Bone, R A, Kyle, P R, Greipp, B, Van Ness, M M, Oken

Publikováno v: British journal of haematology. 100(3)

T-helper blood populations are frequently altered in multiple myeloma (MM). We measured the numbers of naive and activated cell subsets in the blood of a cohort of both previously untreated and treated MM patients. Two-colour flow cytometry to detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1eac3b7ca9cf97a3eb8acc54d7c2d32
https://pubmed.ncbi.nlm.nih.gov/9504626

Zobrazit plný text záznamu

Impairments in immune cell function in B cell chronic lymphocytic leukemia

Autor: M M, Bartik, D, Welker, N E, Kay

Publikováno v: Seminars in oncology. 25(1)

B cell chronic lymphocytic leukemia (B-CLL) is a common clonal B cell leukemia that is often accompanied by a multitude of immune abnormalities. Each immune defect may be linked to several of the common complications affecting B-CLL patients. Further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4004a1c7daae6b8171a1aa20bd376136
https://pubmed.ncbi.nlm.nih.gov/9482524

Zobrazit plný text záznamu

Isolated 13q14 abnormalities and normal karyotypes are associated with typical lymphocyte morphology in B-cell chronic lymphocytic leukemia

Autor: S H, Kroft, W G, Finn, N E, Kay, L C, Peterson

Publikováno v: American journal of clinical pathology. 107(3)

Peripheral blood lymphocyte morphology and karyotype were correlated across the spectrum of cytogenetic abnormalities in 78 previously karyotyped cases of B-cell chronic lymphocytic leukemia (CLL). Cases were classified according to French-American-B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fd9e6cf14313224f3496e0da6ecd99c
https://pubmed.ncbi.nlm.nih.gov/9052377

Zobrazit plný text záznamu

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

Autor: P, Liu, T, Leong, L, Quam, D, Billadeau, N E, Kay, P, Greipp, R A, Kyle, M M, Oken, B, Van Ness

Publikováno v: Blood. 88(7)

Mutations of members of the ras family are among the most common oncogene mutations found in multiple myeloma (MM). We have examined the mutational status of the N- and K-ras genes at codons 12, 13, and 61 in 160 newly diagnosed MM patients enrolled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e26f68fb02f799125d6c258253156200
https://pubmed.ncbi.nlm.nih.gov/8839865

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání