Zobrazeno 1 - 10
of 36
pro vyhledávání: '"N. E. Arnotskaya"'
Publikováno v:
Успехи молекулярной онкологии, Vol 10, Iss 4, Pp 137-148 (2023)
Introduction. There is currently no effective therapy for the treatment of glioblastoma. This is partly explained by the high degree of intra- and intertumor heterogeneity of GB, the source of which is believed to be glioblastoma stem cells (GSC). Th
Externí odkaz:
https://doaj.org/article/ecdc85f70f9a42aaabc8e307610f7e10
Autor:
N. E. Arnotskaya, T. I. Kushnir, I. A. Kudryavtsev, A. A. Mitrofanov, A. Kh. Bekyashev, V. E. Shevchenko
Publikováno v:
Успехи молекулярной онкологии, Vol 10, Iss 2, Pp 117-125 (2023)
Introduction. Glioblastoma (GB) is not yet curable despite recent advances in the treatment of other malignant solid tumors. The management of GB is based solely on histopathological features, imaging of the tumor and its genomic analysis (somatic mu
Externí odkaz:
https://doaj.org/article/abb0fcade6904ce8bcb20f05b47e41ab
Autor:
V. E. Shevchenko, Z. N. Nikiforova, T. I. Kushnir, I. A. Kudryavtsev, A. A. Mitrofanov, A. Kh. Bekyashev, N. E. Arnotskaya
Publikováno v:
Успехи молекулярной онкологии, Vol 9, Iss 3, Pp 60-68 (2022)
Introduction. Treatment of glioblastoma multiforme remains little effective due to the rapidly developing recurrence of the tumor, due to its high tumorigenic potential, resistance to chemoradiation therapy and increased dissemination of glioma stem
Externí odkaz:
https://doaj.org/article/4ed35bbddfe14f3d9a46750dd338e922
Autor:
T. I. Kushnir, N. E. Arnotskaya, I. A. Kudryavtsev, A. A. Mitrofanov, A. K. Bekyashev, V. G. Zgoda, V. E. Shevchenko
Publikováno v:
Успехи молекулярной онкологии, Vol 8, Iss 4, Pp 75-83 (2021)
Introduction. To a large extent, the resistance of glioblastoma multiforme to genotoxic therapy is associated with a dysregulation of responses to DNA damage and repair. Thus, suppression of DNA repair mechanisms is a priority pathway for increasing
Externí odkaz:
https://doaj.org/article/3b189d06398e4493858d8fcda5d99023
Autor:
T. I. Kushnir, N. E. Arnotskaya, I. A. Kudryavtsev, A. A. Mitrofanov, A. K. Bekyashev, V. E. Shevchenko
Publikováno v:
Успехи молекулярной онкологии, Vol 8, Iss 1, Pp 32-40 (2021)
Background. Glioblastoma multiforme (GBM) develops in the hypoxic microenvironment, which plays an important role in the pathogenesis of the disease and is closely associated with tumor growth, development and poor prognosis. Hypoxia increases the re
Externí odkaz:
https://doaj.org/article/79576b6308bf48a68367c78003493741
Publikováno v:
Успехи молекулярной онкологии, Vol 7, Iss 1, Pp 8-16 (2020)
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patien’s median survival rate ranging from 12 to 15 months. Over the last fifteen years, the treatment for GBM has in
Externí odkaz:
https://doaj.org/article/6b0f62504a57411b924abcbfb570f281
Publikováno v:
Успехи молекулярной онкологии, Vol 6, Iss 1, Pp 63-72 (2019)
Background. Treatment of glioblastoma multiforme remains little effective due to the rapidly developing recurrence of the tumor, due to its high tumorigenic potential, resistance to chemoradiation therapy and increased dissemination of glioma stem ce
Externí odkaz:
https://doaj.org/article/acec70657b044d9a9b8f28cdb6ef069b
Publikováno v:
Успехи молекулярной онкологии, Vol 5, Iss 4, Pp 94-103 (2019)
The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in st
Externí odkaz:
https://doaj.org/article/49f2e340a6d4423b95a5b9987533ca0d
Autor:
V. E. Shevchenko, A. S. Bryukhovetskiy, M. V. Filatov, V. S. Burdakov, Z. N. Nikiforova, I. S. Bryukhovetskiy, Yu. D. Vasilets, T. I. Kushnir, N. E. Arnotskaya
Publikováno v:
Успехи молекулярной онкологии, Vol 5, Iss 1, Pp 60-69 (2018)
Background. Multiple myeloma (MM) is a hematologic malignancy of plasma cells. The microenvironment plays a key role in MM cell survival and drug resistance through release of soluble factors, expression of adhesion molecules and release of exosomes
Externí odkaz:
https://doaj.org/article/ab53387211b74acbb314daf245e97323
Autor:
V. E. Shevchenko, I. S. Bryukhovetskiy, Z. N. Nikiforova, S. V. Kovalev, I. A. Kudryavtsev, N. E. Arnotskaya
Publikováno v:
Успехи молекулярной онкологии, Vol 4, Iss 3, Pp 67-74 (2017)
Background. The transforming growth factor beta 1 (TGF-β1) is one of the most important tissue factors secreted by the development of epithelial tumors. Increased expression of TGF-β1 in lung tumors promotes cancer cells survival enhancing their gr
Externí odkaz:
https://doaj.org/article/6f3b40dc61e849f7bcb302a3e8ac2ee8