Zobrazeno 1 - 10
of 32
pro vyhledávání: '"N. D. Staite"'
Publikováno v:
The Journal of Immunology. 157:3153-3158
Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the firm adhesion of leukocytes to venular endothelium and facilitates leukocyte extravasation from the vasculature into inflamed tissue. In addition, ICAM-1 is an important costim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad1406d488eb1764ba152dd6151c4517
https://doi.org/10.4049/jimmunol.157.7.3153
https://doi.org/10.4049/jimmunol.157.7.3153
Autor:
Stephen T. Schlachter, Colin J. Dunn, Sharon K. Shields, Haiyan Wu, Megan Murphy, Danielle G. Aspar, Karen A. Richard, Richard A. Nugent, N. D. Staite, Louise A. Galinet
Publikováno v:
Journal of Medicinal Chemistry. 37:4449-4454
A study of the decomposition of the pyrazoline bisphosphonate ester 2 identified 3 as the sole bisphosphonate component. Evaluation in a delayed-type hypersensitivity granuloma model of chronic inflammation in mice (DTH-GRA) showed 3 to be a potent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef3fa9786169a6c72c26adb3ef63b17
https://doi.org/10.1021/jm00052a004
https://doi.org/10.1021/jm00052a004
Autor:
N. D. Staite, Sharon K. Shields, Megan Murphy, Robert J. Smith, Louise A. Galinet, Colin J. Dunn, Danielle G. Aspar, Karen A. Richard, N. A. Rohloff, Richard A. Nugent, Stephen T. Schlachter
Publikováno v:
Journal of Medicinal Chemistry. 36:134-139
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-1 in ether at 22 degrees C yield pyrazoline bisphosphonate tetraethyl esters 8a-1 in moderate to good yield. These compounds were evaluated in animal models of arthritis: rat adju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d64d030d270dcaf2dc4175aee092981
https://doi.org/10.1021/jm00053a017
https://doi.org/10.1021/jm00053a017
Autor:
N. D. Staite, S. T. Schlachter, C. J. Dunn, Richard A. Nugent, S. K. Shields, D. G. Aspar, L. A. Galinet
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f62168379307a2512e505978177225
https://doi.org/10.1002/chin.199836213
https://doi.org/10.1002/chin.199836213
Autor:
D E Epps, N. D. Staite, Martin R. Deibel, W R Mathews, Karen A. Richard, David M. Guido, Anthony W. Yem
Publikováno v:
Journal of Biological Chemistry. 267:3122-3128
Acrylodan, which normally modifies cysteine residues, was employed to derivatize recombinant interleukin-1 beta (rIL-1 beta) under native conditions, using a reagent:protein ratio of 3:1. Two major covalent protein/acrylodan adducts were generated an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa46beea98bebadecf20105f0fc8ec3
https://doi.org/10.1016/s0021-9258(19)50703-7
https://doi.org/10.1016/s0021-9258(19)50703-7
Publikováno v:
Agents and Actions. 39:C86-C88
The angiogenesis inhibitor AGM-1470 has recently been reported to inhibit collagen-induced arthritis in rats. To determine if the anti-arthritic effects of AGM-1470 might be due to T cell inhibition, we have studied its effects on T cell responses in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0ea4d8dc53d97235caddba6ed9d228
https://doi.org/10.1007/bf01972729
https://doi.org/10.1007/bf01972729
Autor:
K. A. Richard, N. D. Staite
Publikováno v:
Agents and Actions. 39:C93-C95
Six diphosphonates were examined for their ability to alter proliferative responses of mouse bone marrow cells to recombinant human M-CSF and recombinant murine GM-CSF. Risedronate ([2-(3-pyridinyl)-ethylidene] hydroxy bisphosphonic acid) added to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161b1098015703d407b9b3ffa74cdb17
https://doi.org/10.1007/bf01972731
https://doi.org/10.1007/bf01972731
Autor:
D C, Bullard, J M, Mobley, J M, Justen, L M, Sly, J G, Chosay, C J, Dunn, J R, Lindsey, A L, Beaudet, N D, Staite
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(5)
P-selectin plays an important role in leukocyte adherence to microvascular endothelium and is expressed in synovial tissue from patients with rheumatoid arthritis (RA). However, the contribution of P-selectin to the initiation and chronicity of joint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bd0bd43c885b6555d1c9b25170fe11d
https://pubmed.ncbi.nlm.nih.gov/10453030
https://pubmed.ncbi.nlm.nih.gov/10453030
Autor:
Danielle G. Aspar, Louise A. Galinet, Sharon K. Shields, Colin J. Dunn, Stephen T. Schlachter, N. D. Staite, Richard A. Nugent
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(9)
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc173606b5cfcaca160555cd7ef24ed
https://pubmed.ncbi.nlm.nih.gov/9871714
https://pubmed.ncbi.nlm.nih.gov/9871714
Autor:
Robert L. Griffin, J. R. Brashler, S. L. Vonderfecht, N. D. Staite, Cheryl A. Hatfield, Greg E. Winterrowd, Kathy L. Shull, Kathleen A. Ready, Karen P. Kolbasa, I.M. Richards, Raymond F. Krzesicki, Laurel M. Sly, Colin J. Dunn, Jia En Chin, Stephen F. Fidler
Publikováno v:
American journal of respiratory cell and molecular biology. 18(2)
We investigated the effects of in vivo intraperitoneal treatment with the rat monoclonal antibody (mAb), YN1.7.4 (YN1) against intercellular adhesion molecule-1 (ICAM-1) on the ovalbumin (OA)-inhalation-induced infiltration of leukocytes into the air
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c2a627419552159726669211e47393
https://pubmed.ncbi.nlm.nih.gov/9476902
https://pubmed.ncbi.nlm.nih.gov/9476902