Zobrazeno 1 - 10 of 69 pro vyhledávání: '"N. D. Hall"'
1
Lack of activation induced cell death in human T blasts despite CD95L up-regulation: protection from apoptosis by MEK signalling
Autor: L. S. K. Walker, George Boulougouris, N. D. Hall, David M. Sansom, Claire N. Ellwood, Julie D. McLeod, Yusuf I. Patel
Publikováno v: Immunology. 98:569-575
The generation of effective immunity requires that antigen-specific T cells are activated, clonally expanded and ultimately eliminated by apoptosis. The involvement of CD95-mediated apoptosis in T-cell elimination is well established, but the conditi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1977d5dc48850c3dd2586ab73b532c33
https://doi.org/10.1046/j.1365-2567.1999.00925.x
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2
Down-regulation of CD28 via Fas (CD95): influence of CD28 on T-cell apoptosis
Autor: Julie D. McLeod, N. D. Hall, David M. Sansom, Lucy S. K. Walker, George Boulougouris, Yusuf I. Patel
Publikováno v: Immunology. 94:41-47
Following antigen engagement of the T-cell receptor (TCR), T-cell survival is largely dictated by the provision of additional signals, such as those from costimulatory receptors and cytokine receptors. Whilst CD28-mediated signalling is increasingly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dbd09ab1ad5ad2e21ea9e321d0b74cc
https://doi.org/10.1046/j.1365-2567.1998.00490.x
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3
Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals
Autor: C E Edmead, Y I Patel, A Wilson, G Boulougouris, N D Hall, S G Ward, D M Sansom
Publikováno v: The Journal of Immunology. 157:3290-3297
A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40499fc0f3c8b54845682ac8372b43b8
https://doi.org/10.4049/jimmunol.157.8.3290
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4
Effects of antigen presentation on superantigen‐induced apoptosis mediated by Fas/Fas ligand interactions in human T cells
Autor: Julie D. McLeod, Martina Boshell, L. S. K. Walker, N. D. Hall, David M. Sansom, Yusuf I. Patel
Publikováno v: Immunology. 87:586-592
Stimulation of T cells with bacterial superantigens has several distinct functional outcomes including proliferation, anergy and apoptosis. At present however, the mechanisms that dictate whether activation, anergy, or apoptosis predominate are uncle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58e0a34b776e22c2dec5be35df89ced
https://doi.org/10.1046/j.1365-2567.1996.509582.x
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5
DIFFERENTIAL EXPRESSION OF THE COSTIMULATORY MOLECULES B7.1 (CD80) AND B7.2 (CD86) IN RHEUMATOID SYNOVIAL TISSUE
Autor: Peter J. Maddison, David M. Sansom, A. Balsa, J. Dixey, N. D. Hall
Publikováno v: Europe PubMed Central
CD4+ T-lymphocytes require two signals to become activated--antigen receptor (TcR) occupancy and an antigen-presenting cell (APC)-derived costimulus. The latter may be provided by B7.1 (CD80) or B7.2 (CD86) on APC interacting with CD28 on T-cells. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c902871692f7c207e3b73cca2b63da
https://doi.org/10.1093/rheumatology/35.1.33
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6
Detection of anti-topoisomerase I antibodies using a full length human topoisomerase I recombinant protein purified from a baculovirus expression system
Autor: James J. Champoux, Lance Stewart, N. D. Hall, J Whyte, William C. Earnshaw, Leon H. Parker, N J McHugh
Publikováno v: Scopus-Elsevier
SUMMARYTopoisomerase I (topo I) is a major systemic sclerosis (SSc)-associated autoantigen. A cDNA construct encoding full length human topo I in a recombinant baculovirus transfer vector was used to infect insect cells in culture from which recombin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3719011bab90cf422afc51f9b55f35dc
https://doi.org/10.1111/j.1365-2249.1995.tb03655.x
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9
IMPAIRED SUPPRESSOR CELL ACTIVITY DUE TO SURFACE SULPHYDRYL OXIDATION IN RHEUMATOID ARTHRITIS
Autor: C. H. Brown-Galatola, N. D. Hall
Publikováno v: Rheumatology. 31:599-603
Rheumatoid arthritis is a chronic inflammatory disorder with considerable evidence of impaired regulation of the immune response, including defective suppressor cell function, especially in the synovial membrane. We have investigated whether oxidatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5e1f0a4ac8f228c8e169f129171a5b
https://doi.org/10.1093/rheumatology/31.9.599
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