Výsledky vyhledávání - "N. D. Doolittle"

Delayed sodium thiosulfate as an otoprotectant against carboplatin-induced hearing loss in patients with malignant brain tumors

Autor: N D, Doolittle, L L, Muldoon, R E, Brummett, R M, Tyson, C, Lacy, J S, Bubalo, D F, Kraemer, M C, Heinrich, J A, Henry, E A, Neuwelt

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(3)

Carboplatin is effective in the treatment of malignant brain tumors. However, when administered in conjunction with osmotic opening of the blood-brain barrier (BBB), carboplatin is ototoxic. The purpose of this study was to determine whether delayed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efb21f7767e497e95d7b358baa07b016
https://pubmed.ncbi.nlm.nih.gov/11297239

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Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity

Autor: L L, Muldoon, M A, Pagel, R A, Kroll, R E, Brummett, N D, Doolittle, E G, Zuhowski, M J, Egorin, E A, Neuwelt

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(1)

Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective against many human tumors, but their use may be limited by a high incidence of ototoxicity. Delayed administration of the chemoprotective agent sodium thiosulfat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bed62042ec31dd345e248f8dd6d44a0c
https://pubmed.ncbi.nlm.nih.gov/10656463

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Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors

Autor: N D, Doolittle, M E, Miner, W A, Hall, T, Siegal, E, Jerome, E, Osztie, L D, McAllister, J S, Bubalo, D F, Kraemer, D, Fortin, R, Nixon, L L, Muldoon, E A, Neuwelt

Publikováno v: Cancer. 88(3)

The aim of this study was to determine the safety and efficacy of intraarterial chemotherapy with osmotic opening of the blood-brain barrier (BBB) for the treatment of malignant brain tumors when administered across multiple centers.Patients with pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c689b447bf8464d6c1c01a569cdae34d
https://pubmed.ncbi.nlm.nih.gov/10649259

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Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system lymphoma

Autor: L D, McAllister, N D, Doolittle, P E, Guastadisegni, D F, Kraemer, C A, Lacy, J R, Crossen, E A, Neuwelt

Publikováno v: Neurosurgery. 46(1)

Patients with non-acquired immunodeficiency syndrome-related primary central nervous system lymphomas have the potential to achieve durable complete responses without radiotherapy, with treatment using enhanced chemotherapy delivery with blood-brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0940cc04d233a350cc158decd37898f8
https://pubmed.ncbi.nlm.nih.gov/10626935

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First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate

Autor: E A, Neuwelt, R E, Brummett, N D, Doolittle, L L, Muldoon, R A, Kroll, M A, Pagel, R, Dojan, V, Church, L G, Remsen, J S, Bubalo

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(1)

Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an animal model. The purpose of this study was to determine the STS dose required for otoprotection, in patients with malignant brain tumors treated with carbopla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b73259271638e35d2eea9fc990d683af
https://pubmed.ncbi.nlm.nih.gov/9655844

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The potential for complete and durable response in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery

Autor: S A, Dahlborg, A, Petrillo, J R, Crossen, S, Roman-Goldstein, N D, Doolittle, K H, Fuller, E A, Neuwelt

Publikováno v: The cancer journal from Scientific American. 4(2)

Radiographic tumor response and survival were evaluated in the pediatric and young adult population with germ cell tumor, primary CNS lymphoma, or primitive neuroectodermal tumor receiving intra-arterial carboplatin- or methotrexate-based chemotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50298839e0954f4f996bb48b748c257e
https://pubmed.ncbi.nlm.nih.gov/9532409

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Advances in the neurosciences and implications for nursing care

Autor: N D, Doolittle

Publikováno v: The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. 23(4)

There have been numerous advances in the neurosciences in the last decade. These include discoveries in the area of neurogenetics, as well as advances in the prevention, diagnosis and treatment of neurologic diseases such as stroke, epilepsy and Park

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af688be0d1b45d6ee209d5f54e246869
https://pubmed.ncbi.nlm.nih.gov/1833478

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