Zobrazeno 1 - 10
of 84
pro vyhledávání: '"N. Chin Lai"'
Autor:
Mei Hua Gao, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Young Chul Kim, Viet Anh Nguyen Huu, Dorota Skowronska-Krawczyk, Louise Lantier, Raag Bhargava, H. Kirk Hammond
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 220-233 (2020)
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin
Externí odkaz:
https://doaj.org/article/828e78bc7b3643b49492393e8da28c44
Autor:
Dimosthenis Giamouridis, BS, MS, Mei Hua Gao, PhD, N. Chin Lai, PhD, Zhen Tan, PhD, Young Chul Kim, PhD, Tracy Guo, BS, Atsushi Miyanohara, PhD, W. Matthijs Blankesteijn, PhD, Erik Biessen, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
Summary: UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plas
Externí odkaz:
https://doaj.org/article/7f669bc55c904d3d97cf15fd9a30d1e9
Autor:
Mei Hua Gao, PhD, N. Chin Lai, PhD, Dimosthenis Giamouridis, MSc, Young Chul Kim, PhD, Zhen Tan, PhD, Tracy Guo, BS, Wolfgang H. Dillmann, MD, Jorge Suarez, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 617-629 (2016)
Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increas
Externí odkaz:
https://doaj.org/article/c3d4b2955ed24706befb04be3dee1927
Publikováno v:
Human Gene Therapy. 33:1091-1100
We used transverse aortic constriction (TAC) in mice to test the hypothesis thatiurocortin 2/i(iUcn2/i) gene transfer would increase left ventricular (LV) systolic and diastolic function in the pressure-stressed LV. Three groups were studied: (1) con
Autor:
Young Chul Kim, Agnieszka D Truax, Dimosthenis Giamouridis, N Chin Lai, Tracy Guo, H Kirk Hammond, Mei Hua Gao
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0224428 (2019)
IntroductionUrocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose dispo
Externí odkaz:
https://doaj.org/article/a76d1ce9339e432589e71472f8999c89
Autor:
Young Chul Kim, N. Chin Lai, Tracy Guo, Bing Xia, Zhenxing Fu, Mei Hua Gao, Dimosthenis Giamouridis, H. Kirk Hammond
Publikováno v:
Hum Gene Ther
Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated virus 8 encoding urocortin 2 (AAV8.UCn2) increases glucose disposal in models of insulin res
Autor:
Dimosthenis Giamouridis, Young Chul Kim, H. Kirk Hammond, Bing Xia, Mei Hua Gao, Zhen Tan, Tracy Guo, N. Chin Lai
Publikováno v:
Hum Gene Ther
A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6) retains beneficial effects of AC6 expression, without increasing cyclic adenosine monophosphate generation. The effects of cardiac-dir
Autor:
Erik A.L. Biessen, W. Matthijs Blankesteijn, Atsushi Miyanohara, Dimosthenis Giamouridis, H. Kirk Hammond, Tracy Guo, Mei Hua Gao, N. Chin Lai
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 28, iss 1
Molecular therapy 28(1), 180-188 (2020). doi:10.1016/j.ymthe.2019.10.003
Mol Ther
Molecular Therapy, 28(1), 180-188. Cell Press
Molecular therapy 28(1), 180-188 (2020). doi:10.1016/j.ymthe.2019.10.003
Mol Ther
Molecular Therapy, 28(1), 180-188. Cell Press
Molecular therapy 28(1), 180-188 (2020). doi:10.1016/j.ymthe.2019.10.003
Published by Nature Publ. Group, New York, NY
Published by Nature Publ. Group, New York, NY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bb326b7ca61a11764ff55a2447b6d1
https://escholarship.org/uc/item/4631v0rn
https://escholarship.org/uc/item/4631v0rn
Autor:
Atsushi Miyanohara, Tracy Guo, Dimosthenis Giamouridis, Matthijs Blankesteijn, H. Kirk Hammond, Erik A.L. Biessen, Young Chul Kim, N. Chin Lai, Mei Hua Gao, Zhen Tan
Publikováno v:
Human Gene Therapy, 30(1), 10-20. Mary Ann Liebert Inc.
Peptide infusions of peptides the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3), have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuitable for chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3889b3fe9318d54cd5b449cd104d72bc
https://cris.maastrichtuniversity.nl/en/publications/4d752fe3-a7a2-4f49-bb2d-1586f12fdb4c
https://cris.maastrichtuniversity.nl/en/publications/4d752fe3-a7a2-4f49-bb2d-1586f12fdb4c
Autor:
Atsushi Miyanohara, Zhen Tan, N. Chin Lai, Dimosthenis Giamouridis, Mei Hua Gao, H. Kirk Hammond, W. Matthijs Blankesteijn, Young Chul Kim, Erik A.L. Biessen, Tracy Guo
Publikováno v:
JACC Basic to translational science 3(2), 249-264 (2018). doi:10.1016/j.jacbts.2017.12.004
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
JACC: Basic to Translational Science, 3(2), 249-264. Elsevier
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
JACC: Basic to Translational Science, 3(2), 249-264. Elsevier
JACC: Basic to Translational Science
Visual Abstract
Highlights • UCn2 and UCn3 gene transfer increased LV peak +dP/dt (systolic function) and LV peak −dP/dt (diastolic function) significantly and similarly. • Both genes increased LV levels of SERCA2a, and isolated cardiac my
Highlights • UCn2 and UCn3 gene transfer increased LV peak +dP/dt (systolic function) and LV peak −dP/dt (diastolic function) significantly and similarly. • Both genes increased LV levels of SERCA2a, and isolated cardiac my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67e30518cf30bff80774cca74b02ab7