Mass balance study of [14C] rabeprazole following oral administration in healthy subjects

Autor: Setoyama T, T J Humphries, Hasegawa J, W J Drijfhout, N C van de Merbel

Publikováno v: International Journal of clinical Pharmacology and Therapeutics, 44(11), 557-65

The study was designed to determine the excretion balance of radiolabeled rabeprazole in urine and feces and to examine the metabolite profile in plasma, urine and feces after a single oral dose of [14C] rabeprazole, preceded by once daily dose of ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cca555d5cf232584c70dbcd7f8f8d5
https://doi.org/10.5414/cpp44557

Is HPLC becoming obsolete for bioanalysis?

Autor: N. C. Van De Merbel

Publikováno v: Chromatographia. 55:S53-S57

Over the last decade, LC-MS-MS has replaced HPLC with conventional detection as the first choice for quantitative bioanalysis. Important reasons for this are the improved sensitivity, selectivity and speed of LC-MS-MS. Still, it is now also recognize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5cdafba02c4067b2a2b8a4e790d59e1
https://doi.org/10.1007/bf02493353

LC phases improve, but not all assays do: Metformin bioanalysis revisited

Autor: B Oosterhuis, G. Wilkens, S. Fowles, J.H.G Jonkman, N. C. Van De Merbel

Publikováno v: Chromatographia. 47:542-546

Two assay methods for the antidiabetic metformin, one developed and validated in 1990 and one developed and validated in 1996, are compared. The first method, using an octadecyl phase and an ion pairing agent in the eluent, could not be reproduced so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::394a1bc80c15ececa5ee1676fff0b024
https://doi.org/10.1007/bf02467492

Sampling and analytical strategies in on-line bioprocess monitoring and control

Autor: U.A.Th. Brinkman, Henk Lingeman, N. C. Van De Merbel

Publikováno v: Journal of Chromatography A, 725, 13-27. Elsevier
van de Merbel, N C, Lingeman, H & Brinkman, U A T 1996, ' Sampling and analytical strategies in
bioproces monitoring and control. ', Journal of Chromatography A, vol. 725, pp. 13-27 . https://doi.org/10.1016/0021-9673(96)84622-X

The use of on-line systems for the determination of small organic molecules during biotechnological processes is reviewed. Since sampling of part of the culture medium is an inherent and crucial part of the use of on-line systems, several sampling sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d53a622027d46470ad0dfb9e60496d
https://doi.org/10.1016/0021-9673(96)84622-x

An automated monitoring system using on-line ultrafiltration and column liquid chromatography for Aspergillus niger fermentations

Autor: G. J. G. Ruijter, N. C. van de Merbel, J. Visser, H. Lingeman, U. A. Th. Brinkman

Publikováno v: Applied Microbiology and Biotechnology 41 (1994)
Applied Microbiology and Biotechnology, 41, 658-663

An automated system for the monitoring of fermentations of filamentous fungi is described. The system is based on the on-line combination of ultrafiltration, for the removal of cellular and macromolecular material from the fermentation broth. and col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a9ed27d0e087bf44661440cefdf397
https://doi.org/10.1007/bf00167281