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Autor:
G. G. Krishna Murthy, Joseph D. Brain, N. C. Long, Robert H. Schiestl, Jason D. Morrow, Balz Frei, Jung H. Suh
Publikováno v:
Journal of Applied Physiology. 91:1694-1700
Ozone (O3), a major component of urban air pollution, is a strong oxidizing agent that can cause lung injury and inflammation. In the present study, we investigated the effect of inhalation of O3 on levels of F2-isoprostanes in bronchoalveolar lavage
Publikováno v:
Clinical & Experimental Allergy. 29:37-47
Human asthma is characterized by three critical phenotypic traits: intermittent reversible airway obstruction, airway hyperresponsiveness and airway inflammation. In animal models of asthma, airway hyperresponsiveness is an important feature. This tr
Publikováno v:
Environmental Health Perspectives
The Kuwaiti oil wells set on fire by retreating Iraqi troops at the end of the Persian Gulf War released complex particles, inorganic and organic gases, and hydrocarbons into the atmosphere, damaging the environment where many people live and work. I
Autor:
Jennifer A. Love, John J. Godleski, N. C. Long, Inn-Wen Chong, Michael M. Shi, Joseph D. Paulauskis
Publikováno v:
Inflammation. 22:29-43
Chemokines are important inflammatory mediators that function by activating and recruiting leukocytes to an inflamed tissue. We have recently cDNA cloned the rat chemokine macrophage inflammatory protein–1α (MIP-1α) (1). In the present study, we
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 155:1222-1229
We evaluated the role of C fibers in the development of airway hyperresponsiveness in a rat model of chronic bronchitis. Neonatal rats were treated with capsaicin (50 mg/kg, subcutaneously), a procedure which results in permanent depletion of tachyki
Autor:
N. C. Long
Publikováno v:
Physiology. 11:83-90
The body's response to infectious disease is the result of eons of coevolution with pathogens. Examination of the physiology of the symptoms of infection shows that many aspects of the acute phase response to infectious disease, including fever, loss
Autor:
N. C. Long, Louise Boulet, Douglas J. Pon, Stephanie A. Shore, C J van Staden, William A. Skornik, Ian W. Rodger, Lester Kobzik
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 151:1931-1938
Chronic exposure of rats to high concentrations of SO2 gas causes pathologic changes in airway similar to those seen in human chronic bronchitis. The purpose of this study was to examine the pulmonary mechanical correlates of these changes and to qua
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 259:R724-R728
The roles of interleukin 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF) in lipopolysaccharide (LPS)-induced fever were investigated in the rat. We used antisera against IL-1 beta and TNF to determine whether we could alter the fever by bloc
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 258:R591-R595
Psychological stress (e.g., exposure to a novel environment) causes a rapid rise in body temperature in rats. In this study, we examined the roles of physical activity and the immune cytokine tumor necrosis factor or cachectin (TNF) in this temperatu