Zobrazeno 1 - 10
of 24
pro vyhledávání: '"N. C. Cohen"'
Autor:
Jürgen Maibaum, N. C. Cohen, Christian Schnell, Robert Mah, Jeanette Marjorie Wood, Keith Menear, Yasuchika Yamaguchi, Frederic Cumin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4863-4867
Novel nonpeptide small molecule renin inhibitors bearing an N-isopropyl P1 motif were designed based on initial lead structures 1 and aliskiren (2). (P3–P1)-Benzamide derivatives such as 9a and 34, as well as the corresponding P1 basic tertiary ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6fba3d27725345a6f687dd7422758f
https://doi.org/10.1016/j.bmcl.2009.05.128
https://doi.org/10.1016/j.bmcl.2009.05.128
Autor:
Alice Stanton, Eoin O'Brien, Joseph Rahuel, Walter Schilling, Vittorio Rasetti, Markus G. Grütter, Martin P. Bedigian, Robert Mah, Chris Jensen, Yasuchika Yamaguchi, Hans-Peter Baum, Christian Schnell, Walter Fuhrer, Pascal Rigollier, Jürgen Maibaum, Jeanette Marjorie Wood, N. C. Cohen, Frederic Cumin, Peter Herold, Stefan Stutz, Heinrich Rüger, Richard Dr. Göschke
Publikováno v:
Biochemical and Biophysical Research Communications. 308:698-705
Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial infarction, and heart failure, the leading causes of death in the Western world. Inhibitors of the renin-angiotensin system (RAS) have proven to be successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bbec64e62a19eb4d4c1627b255a56b
https://doi.org/10.1016/s0006-291x(03)01451-7
https://doi.org/10.1016/s0006-291x(03)01451-7
Autor:
J. M. Wood, Vittorio Rasetti, Frederic Cumin, Walter Fuhrer, Richard Goeschke, N. C. Cohen, Jürgen Maibaum, Heinrich Rueeger
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354c0edb86d6a203e736e75cf2ab1967
https://doi.org/10.1002/chin.199648267
https://doi.org/10.1002/chin.199648267
Publikováno v:
Journal of Medicinal Chemistry. 33:883-894
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6034c17fb4747737df9173c9408eeb23
https://doi.org/10.1021/jm00165a001
https://doi.org/10.1021/jm00165a001
Autor:
Pascal Rigollier, Jeanette Marjorie Wood, Stefan Stutz, Jürgen Maibaum, N. C. Cohen, Joseph Rahuel, Walter Fuhrer, Hans-Peter Baum, Vittorio Rasetti, Walter Schilling, Frederic Cumin, Markus Gruetter, Christian Schnell, Peter Forgiarini, Richard Dr. Göschke, Trixie Wagner
Publikováno v:
Journal of medicinal chemistry. 50(20)
The action of renin is the rate-limiting step of the renin-angiotensin system (RAS), a key regulator of blood pressure. Effective renin inhibitors directly block the RAS entirely at source and, thus, may provide a vital weapon for hypertension therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0798531097bb1d65978851f1e51d48ff
https://pubmed.ncbi.nlm.nih.gov/17824679
https://pubmed.ncbi.nlm.nih.gov/17824679
Autor:
Walter Fuhrer, Jeanette Marjorie Wood, N. C. Cohen, Stefan Stutz, Walter Schilling, Jiirgen Maibaum, Christian Schnell, Richard Dr. Göschke, Yasuchika Yamaguchi, Pascal Rigollier, Joseph Rahuel, Hans-Peter Baum, Frederic Cumin, Markus Gruetter
Publikováno v:
Journal of medicinal chemistry. 50(20)
Due to its function in the rate limiting initial step of the renin-angiotensin system, renin is a particularly promising target for drugs designed to control hypertension, a growing risk to health worldwide. Despite vast efforts over more than two de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf40095c26286b487d26d34a88f84053
https://pubmed.ncbi.nlm.nih.gov/17824680
https://pubmed.ncbi.nlm.nih.gov/17824680
Autor:
Vittorio Rasetti, Frederic Cumin, Joseph Rahuel, Jürgen Maibaum, M.G. Grutter, Stefan Stutz, Richard Dr. Göschke, Walter Fuhrer, J M Wood, Heinrich Rueger, N. C. Cohen
Publikováno v:
Chemistrybiology. 7(7)
Background: The aspartic proteinase renin plays an important physiological role in the regulation of blood pressure. It catalyses the first step in the conversion of angiotensinogen to the hormone angiotensin II. In the past, potent peptide inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ade4c85285be3b88d464c06099d9f4
https://pubmed.ncbi.nlm.nih.gov/10903938
https://pubmed.ncbi.nlm.nih.gov/10903938
Autor:
N C, Cohen, V, Tschinke
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::588c5c2b7830c7905a6737660a0845e7
https://pubmed.ncbi.nlm.nih.gov/8545538
https://pubmed.ncbi.nlm.nih.gov/8545538
Publikováno v:
ChemInform. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1951013cb4269aa565c4419ff7cdac
https://doi.org/10.1002/chin.199032350
https://doi.org/10.1002/chin.199032350
Publikováno v:
Journal of Molecular Graphics. 6:182-189
This paper proposes a three-dimensional molecular representation visualizing in the same frame the hydrophobic and geometric properties of a molecule. Based on the concept of molecular lipophilicity potential, the representation consists of the varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8512a8ab63b22d8381aadc8166f1981f
https://doi.org/10.1016/s0263-7855(98)80001-5
https://doi.org/10.1016/s0263-7855(98)80001-5