Výsledky vyhledávání

A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice

Autor: W S Simonet, S J Lauer, N Bucay, J M Taylor

Publikováno v: Journal of Biological Chemistry. 268:8221-8229

The human apolipoprotein (apo) E and apoC-I genes are located 5 kilobases apart in the same transcriptional orientation on chromosome 19, and they are expressed at high levels in the liver with lower levels of expression in selected other tissues. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fce03a91f97770de7a2a695194b2bd2
https://doi.org/10.1016/s0021-9258(18)53085-4

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Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice

Autor: Robert E. Pitas, J M Taylor, W S Simonet, N Bucay, S J Lauer

Publikováno v: Journal of Biological Chemistry. 266:8651-8654

To investigate the mechanisms controlling tissue-specific expression of the human apolipoprotein (apo) E/C-I gene locus, human apoE and apoC-I gene constructs containing various lengths of the 5'-flanking or 3'-flanking region were used to create tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::689b1c0e23c374ce8e03079f8939e367
https://doi.org/10.1016/s0021-9258(18)31491-1

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In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice

Autor: D O Wirak, Karl H. Weisgraber, Robert E. Pitas, J M Taylor, M E Stevens, S J Lauer, N Bucay, W S Simonet

Publikováno v: Journal of Biological Chemistry. 265:10809-10812

Human apolipoprotein (apo) E gene constructs with 30 or 5 kilobases of 5'-flanking and 1.5 kilobases of 3'-flanking regions were used to create transgenic mice. High levels of human apoE mRNA were present in the transgenic kidney, but none was detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b53bbb5055a801198433bd791a55ee2
https://doi.org/10.1016/s0021-9258(19)38516-3

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Evidence that the protein tyrosine phosphatase (PC12,Br7,Sl) gamma (-) isoform modulates chondrogenic patterning and growth

Autor: K A, Augustine, R M, Rossi, S M, Silbiger, N, Bucay, D, Duryea, W S, Marshall, E S, Medlock

Publikováno v: The International journal of developmental biology. 44(4)

One of the earliest events in bone morphogenesis is the condensation of embryonic mesenchymal cells into chondroblasts and their subsequent proliferation and differentiation into chondrocytes. During this time, certain signaling cascades operate to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49c409e41d5fe899c12a9217e4a1d477
https://pubmed.ncbi.nlm.nih.gov/10949045

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Protein tyrosine phosphatase (PC12, Br7,S1) family: expression characterization in the adult human and mouse

Autor: K A, Augustine, S M, Silbiger, N, Bucay, L, Ulias, A, Boynton, L D, Trebasky, E S, Medlock

Publikováno v: The Anatomical record. 258(3)

Protein tyrosine phosphatases (PTPs) play important roles in modulating signals transduced by tyrosine kinases. Certain phosphatases have been implicated as having important roles in embryonic development as well as in adult physiology. Although both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82afe999e4dec1b5d2d6ea8a8a507077
https://pubmed.ncbi.nlm.nih.gov/10705342

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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Autor: Colin R. Dunstan, C. Capparelli, N. Bucay, William S. Simonet, S. Scully, William J. Boyle, Ildiko Sarosi, Sean Morony, Hong Lin Tan, David L. Lacey, Weilong Xu, John E. Tarpley

Publikováno v: Genesdevelopment. 12(9)

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG-/- mice exhibit a decrease in total bone density ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f61c5a9314dd7974902e9656157673
https://pubmed.ncbi.nlm.nih.gov/9573043

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Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung

Autor: Lan Zhou, D. M. Danilenko, Hung Q. Nguyen, N. Bucay, T. R. Ulich, Susan E. Wert, Jeffrey A. Whitsett, W. S. Simonet, A. Thomason, Margaret L. DeRose

Expression of human keratinocyte growth factor (KGF/FGF-7) was directed to epithelial cells of the developing embryonic lung of transgenic mice disrupting normal pulmonary morphogenesis during the pseudoglandular stage of development. By embryonic da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1081d3c49dcbb07853b3f5bf8e60a2e
https://europepmc.org/articles/PMC40377/