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In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy model

Autor: J. E. Van Lier, D. Le Garrec, Jean-Christophe Leroux, V. Lenaerts, N. Brasseur, J. Taillefer

Publikováno v: Journal of Pharmacy and Pharmacology. 53:155-166

pH-sensitive polymeric micelles of randomly and terminally alkylated N-isopropylacrylamide copolymers were prepared and characterized. Aluminium chloride phthalocyanine (AlClPc), a second generation sensitizer for the photodynamic therapy of cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abadfa0fbc9d0cef69c601c427c5667
https://doi.org/10.1211/0022357011775352

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Water-soluble aluminium phthalocyanine–polymer conjugates for PDT: photodynamic activities and pharmacokinetics in tumour-bearing mice

Autor: C. La Madeleine, N. Brasseur, J. E. Van Lier, René Ouellet

Publikováno v: British Journal of Cancer

The potential use of unsubstituted aluminium phthalocyanine (AlClPc) as a sensitizer for photodynamic therapy (PDT) of cancer has not been fully exploited in spite of its higher efficiency as compared to the sulphonated derivatives. This is largely d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153dc7c0c650d7b45c31dd99d63b6dd5
https://doi.org/10.1038/sj.bjc.6690557

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Influence of Molecular Oxygen on the Charge Transfer Properties of a Co(II)Porphyrin-Al(III)Phthalocyanine Aggregate. Excited States Dynamics and Photobiological Activities

Autor: D. Lexa, Thierry Fournier, C. La Madeleine, D. Houde, Réjean Langlois, Z. Liu, J. E. Van Lier, N. Brasseur, Thu-Hoa Tran-Thi

Publikováno v: The Journal of Physical Chemistry A. 103:1179-1186

We report the novel cooperative properties of a complex obtained by self-assembling in solution a tetracationic cobalt porphyrin, CoIIP4+, and a tetraanionic sulfoaluminum phthalocyanine, AlIIIPc4-. In the ground state, the complex displays a charge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8794de43c23702e497cec915f0c5eb6
https://doi.org/10.1021/jp983936r

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Measurement of Tumor Vascular Damage in Mice with 99m Tc‐MIBI Following Photodynamic Therapy

Autor: Johan E. van Ller, N. Brasseur, Karina Lewis, Jacques Rousseau

Publikováno v: Photochemistry and Photobiology. 64:702-706

The clinical perfusion agent 99mTc-MIBI was used to monitor changes in tumor vascular perfusion (TVP) induced by Photofrin (PII)-mediated photodynamic therapy (PDT). BALB/c mice bearing an EMT-6 tumor on each hind thigh were given an intravenous inje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cd55a277b175bfc9bafd508799041e
https://doi.org/10.1111/j.1751-1097.1996.tb03127.x

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Photodynamic therapy of tumours with hexadecafluoro zinc phthalocyanine formulated in PEG-coated poly(lactic acid) nanoparticles

Autor: Johan E. van Lier, Svetlana V. Kudrevich, Jacques Rousseau, Eric Allémann, Karina Lewis, N. Brasseur

Publikováno v: International Journal of Cancer. 66:821-824

Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2956320f73bea7fce51b07bc8262f98b
https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<821::aid-ijc19>3.0.co

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Spectre d’action de la reponse tumorale induite par le bis(dimethylthexylsiloxy) 2,3-naphtalocyanine de silicium chez la souris

Autor: N. Brasseur, R. Ouellet, D. Houde, J. E. Van Lier, S. Marengo

Publikováno v: Journal de Chimie Physique. 93:29-33

La photochimiotherapie (PCT) du cancer consiste a traiter les tissus tumoraux avec la lumiere visible apres l'administration systemique d'agents photosensibilisants du type des porphyrines. Nous avons recemment demontre le potentiel des derives bis(a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::474a51b72d1a7f06f5df17f081ed59e6
https://doi.org/10.1051/jcp/1996930029

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Combination toxicity of etoposide (VP-16) and photosensitisation with a water-soluble aluminium phthalocyanine in K562 human leukaemic cells

Autor: N. Brasseur, J. E. Van Lier, Tsvetan G. Gantchev

Publikováno v: British Journal of Cancer

Etoposide (VP-16) is an anti-cancer drug commonly used against several types of tumours and leukaemia, either alone or in combination chemotherapy. Photodynamic therapy (PDT) is another, relatively new modality for treatment of various malignancies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ab1fc6ea51e089336b2dce64f650ce
http://europepmc.org/articles/PMC2074854

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Activité biologique de dérivés 2,3-naphtalocyanines de silicium comme sensibilisateurs potentiels en photochimiothérapie du cancer

Autor: N. Brasseur, R. Langlois, D. Houde, J. E. Van Lier, R. Ouellet, S. Marengo, T. L. Nguyen

Publikováno v: Journal de Chimie Physique. 91:1011-1017

La photochimiotherapie (PCT) du cancer repose sur l'activation par la lumiere rouge d'agents photosensibilisants du type des porphyrines, qui sont retenus preferentiellement par les tissus tumoraux apres leur administration systemique. Au cours des d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5034718d3355cb4dc47037767415fc8e
https://doi.org/10.1051/jcp/1994911011

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