Výsledky vyhledávání - "N. Bischofberger"

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Akademický článek

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Novel carbon molecular sieve honeycomb membrane module: configuration and membrane characterization

Autor: N. Bischofberger, Adélio Mendes, J. Rathenow, S. Lagorsse, A. Leite, Fernão D. Magalhães

Publikováno v: Carbon. 43:809-819

A new production concept of carbon molecular sieve membranes modules is described. The supported membrane synthesis process allows for industrial production with uniform and reproducible properties, using flat membranes as a starting precursor. The c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1baffef9c8850740230a470c7968dee
https://doi.org/10.1016/j.carbon.2004.11.012

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Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs

Autor: M. N. Arimilli, J. P. Shaw, R. Oliyai, Choung U. Kim, K. C. Cundy, A. Mulato, J. Dougherty, N. Bischofberger

Publikováno v: Antiviral Chemistry and Chemotherapy. 8:557-564

Potentially orally bioavailable prodrugs of the antiretroviral agent 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated. Alkyl methyl carbamates were synthesized by alkylation of PMPA with the corresponding alkyl chloromethyl carbonate and N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53e68a6effe6683ad11d9e7d4f958a75
https://doi.org/10.1177/095632029700800610

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Acyclic Phosphonomethylether Nucleoside Inhibitors of Respiratory Viruses

Autor: John H. Huffman, M. A. Williams, N. Bischofberger, W. Yang, Dale L. Barnard, W. Lew, J. P. Dougherty, Robert W. Sidwell, Choung U. Kim

Publikováno v: Antiviral Chemistry and Chemotherapy. 8:223-233

A series of acyclic phosphonomethylether nucleosides were synthesized and then evaluated for inhibitory activity against respiratory viruses of clinical significance using CPE inhibition, neutral red uptake and virus yield reduction assays. Of the 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c8a143ce30d833bebeed77fdae700b7
https://doi.org/10.1177/095632029700800306

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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Autor: W. Lew, S Swaminathan, Raymond C. Stevens, Min Chen, C. Y. Tai, N Bischofberger, Lijun Zhang, W. G. Laver, Hua-Kun Liu, M.A. Williams, C U Kim, D. B. Mendel

Publikováno v: Journal of the American Chemical Society. 119:681-690

The design, synthesis, and in vitro evaluation of the novel carbocycles as transition-state-based inhibitors of influenza neuraminidase (NA) are described. The double bond position in the carbocyclic analogues plays an important role in NA inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e916cab1b14a27816c0b34b423e9882
https://doi.org/10.1021/ja963036t

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Purinoceptors in the central nervous system

Publikováno v: Scopus-Elsevier

New exciting developments on the occurrence and functional role of purinoceptors in mammalian brain were presented at the session Purinoceptors in the central nervous system chaired by Flaminio Cattabeni and Tom Dunwiddie at the Purines '96 internati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cdd827fce39d4b1ed2c709208d5e2a
https://doi.org/10.1002/(sici)1098-2299(199611/12)39:3/4<361::aid-ddr17>3.0.co

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Inhibition of HIV-1 RNase H Activity by Nucleotide Dimers and Monomers

Autor: S. H. Krawczyk, J. M. Cherrington, N. Bischofberger, S. J. W. Allen, A. S. Mulato, L. R. McGee

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:37-45

Nucleotide dimers and monomers were shown to inhibit human immunodeficiency virus type 1 (HIV) RNase H activity. Several effective inhibitors were identified and placed into three general groups based on biochemical characterization of their inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25f9e690fd1d0b02b06e1a3f3ed532c8
https://doi.org/10.1177/095632029600700107

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Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ

Autor: J. M. Cherrington, N. Bischofberger, S. J. W. Allen, Ming S. Chen

Publikováno v: Antiviral Chemistry and Chemotherapy. 6:217-221

The inhibitory effects of the diphosphates of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its analogues on HIV reverse transcriptase and human DNA polymerases α, β, and γ have been studied. The analogues investigated are the diphosphates of 9-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::084ce8fdb0311d172884dcf8d78cdb17
https://doi.org/10.1177/095632029500600403

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In vivo Antiretroviral Efficacy of Oral bis(POM)-PMEA, the bis(Pivaloyloxymethyl)prodrug of 9-(2-Phosphonylmethoxyethyl) adenine (PMEA)

Autor: E. De Clercq, Johan Neyts, Jan Balzarini, N. Bischofberger, Lieve Naesens

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:767-770

The bis-pivaloyloxymethyl(POM)- and diphenyl-ester prodrugs of the broad spectrum antiviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) have been evaluated in vivo for antiviral efficacy upon oral administration in severe combined immune deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::752d6e15b9b9783a2f2436239f2380f6
https://doi.org/10.1080/15257779508012468

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