Zobrazeno 1 - 10
of 17
pro vyhledávání: '"N. B. Dyatkina"'
Autor:
Anne-Marie Aubertin, Jean Louis Imbach, Christian Périgaud, Gilles Gosselin, Alexander A. Krayevsky, Andrey A. Arzumanov, David Egron, N. B. Dyatkina
Publikováno v:
Bioorganic Chemistry. 29:333-344
The synthesis, in vitro anti-HIV activity and stability studies of the 5'-fluorophosphate derivative of 3'-azido-3'-deoxythymidine (AZT) are reported. The results support the hypothesis that this phosphorylated entity exerts its biological effect via
Autor:
N. B. Dyatkina, Marina K. Kukhanova, L. S. Victorova, Alexander A. Krayevsky, Andrey A. Arzumanov
Publikováno v:
Nucleosides and Nucleotides. 14:91-103
The new thymidine 5′-O-triphosphate analogs—thymidine 5′-O-α-phenylphosphonyl-β, γ-diphosphate 4, 3′-fluoro-3′-deoxythymidine 5′-O-α-phenylphosphonyl-β, γ-diphosphate 5 and thymidine 5′-O-α-decylphosphonyl-β, γ-diphosphate 6 we
Autor:
I. Rosenberg, E. A. Shirokova, Alexander A. Krayevsky, N. B. Dyatkina, K. A. Watanabe, J. Matulic-Adamic, Andrey A. Arzumanov
Publikováno v:
Nucleosides and Nucleotides. 12:1085-1092
Treatment of 3′-fluoro-3′-deoxythymidine (FLT), 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxyadenosine (ddA) with tris(1,1,1,3,3,3-hexafluoro-2-propyl)phosphite or phosphorous acid and N,N'-dicyclohexylcarbodiimide produced the corre
Autor:
N. B. Dyatkina, Lyubov S. Victorova, Andrey A. Arzumanov, Marina K. Kukhanova, A. A. Krayevsky
Publikováno v:
ChemInform. 26
Autor:
E. A. Shirokova, R. Sh. Beabealashvilli, L. E. Goryunova, L. S. Victorova, A. V. Shipitsin, Chris J. Hamilton, N. B. Dyatkina, A. A. Krayevsky
Publikováno v:
ChemInform. 30
Autor:
Alexander A. Krayevsky, N. B. Dyatkina, Dmitry Ju. Mozzherin, Atrazhev Am, Lubov S. Victorova, Marina K. Kukhanova
Publikováno v:
Nucleic Acids Research. 20:783-789
3'-Fluoro-2',3'-dideoxythymidine 5'-(alpha-methylphosphonyl)-beta,gamma- diphosphate and 2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta, gamma- diphosphate have been synthesized. Both compounds are incorporated into DNA chains during catalysis by
Autor:
C. J. Hamilton, Stanley M. Roberts, Alexander A. Krayevsky, N. B. Dyatkina, L. E. Goryunova, R. Sh. Beabealashvilli, L. S. Victorova, E. A. Shirokova, A. V. Shipitsin
Publikováno v:
Nucleosidesnucleotides. 18(4-5)
The design of dNTP analogs with increased stability in vivo could produce a new group of highly effective inhibitors of HIV reproduction. The advantages of such compounds would be as follows: (i) Independence on the phosphorylation process catalyzed
Autor:
Fritz Theil, Alexander A. Krayevsky, E. A. Shirokova, Von Janta Lipinski Mj, Dmitry G. Semizarov, Jean Louis Imbach, Gilles Gosselin, L. S. Victorova, N. B. Dyatkina
Publikováno v:
Nucleosidesnucleotides. 18(4-5)
Theoretical and experimental analysis of interaction of modified D- and L- dNTP as substrates for template-dependent and template-independent DNA polymerases was performed. It is shown that if the modified nucleoside 5′-triphosphates do not contain
Autor:
Dmitry G. Semizarov, Bernard Rayner, Sophie Vichier-Guerre, N. B. Dyatkina, Alexander A. Krayevsky, Jean-Louis Imbach, Albert Meyer, Gilles Gosselin, Andrey A. Arzumanov
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1997, 272 (14), pp.9556-60
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1997, 272 (14), pp.9556-60
International audience; All four possible stereoisomers of dNTP with regard to deoxyribofuranose C-1' and C-4' carbon atoms were studied as substrates for several template-dependent DNA polymerases and template-independent terminal deoxynucleotidyl t
Publikováno v:
FEBS letters. 354(2)
The substrate properties of four carbocyclic D and L nucleoside 5'-triphosphate analogs toward HIV and AMV reverse transcriptases and terminal deoxynucleotidyl transferase were evaluated. The compounds of the D-beta and L-beta series were found to be