Zobrazeno 1 - 8
of 8
pro vyhledávání: '"N. Andrew Whitlock"'
Autor:
Bryce Alden Harrison, Lakshman Samala, Nita Patel, Zheng Y. Almstead, N. Andrew Whitlock, Ross Mabon, Dennis S. Rice, Nicole Cathleen Goodwin, Beth McKnight, Yulian Zhang, Jason P. Healy, Shuli Wang, Suma Gopinathan, Gardyan Michael Walter, David B. Rawlins, Alan Wilson, Terry R. Stouch, Ying Liu, Brian D. Hamman, Brett A. Marinelli, Hugh Alfred Burgoon
Publikováno v:
ACS Medicinal Chemistry Letters. 6:84-88
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously reported LIM kinase inhibitors suffered from poor aqueous stability due to solvolysis of the cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd87df001b841d60f0512718b8b7ce9
https://doi.org/10.1021/ml500367g
https://doi.org/10.1021/ml500367g
Publikováno v:
Investigative ophthalmologyvisual science. 51(12)
Purpose Glucocorticoids are potent modulators of the immune system and are useful in treating systemic and ocular diseases, but they can increase intraocular pressure (IOP) in susceptible persons. Steroid-induced ocular hypertension resembles several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf312e12bc0f3e91ed897ae1a3bb8428
https://pubmed.ncbi.nlm.nih.gov/20671272
https://pubmed.ncbi.nlm.nih.gov/20671272
Autor:
Billie Key, Michael Victor Voronkov, Michael J. Crist, N. Andrew Whitlock, Beth McKnight, Suma Gopinathan, Gardyan Michael Walter, Kun Jian Gu, Bryce Alden Harrison, Zheng Y. Almstead, Craig E. Crosson, Ross Mabon, Dennis S. Rice, Phil W. Yates, Alan G. E. Wilson, Jason Allen, Nita Patel, Ying Liu, Brian D. Hamman, David B. Rawlins, Qingyun Liu, Yulian Zhang, Lawrence F. Courtney, Julia Zhou, S. David Kimball
Publikováno v:
Journal of medicinal chemistry. 52(21)
The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymatic and cellular assays and good selectivity against ROCK. After topical dosing to the eye in a steroid induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e4f9457a81261ca191393308284554
https://pubmed.ncbi.nlm.nih.gov/19831390
https://pubmed.ncbi.nlm.nih.gov/19831390
Autor:
Brenda Gerhardt, Derek E. Eberhart, Travis Mixon, N. Andrew Whitlock, Alan G. E. Wilson, Xiang-Qing Yu, Bryce Alden Harrison, Dennis S. Rice, Alejandro Abuin
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 25(3)
Goals of this study were to determine if pharmacological or genetic inhibition of Rho-associated coiled coil containing protein kinases (known as ROCK1 and ROCK2) alters intraocular pressure (IOP) in mice.Micro-cannulation of the anterior chamber was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff8eb61599569e989fa5ca587f30881
https://pubmed.ncbi.nlm.nih.gov/19456252
https://pubmed.ncbi.nlm.nih.gov/19456252
Publikováno v:
Investigative ophthalmologyvisual science. 46(3)
Purpose Hsp27 is a well-characterized and studied antiapoptotic protein. A recent study reported that Hsp27 is upregulated in the retina after retinal ischemic preconditioning. The timing of this upregulation of Hsp27 correlates with the protective e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0d7b643a0cc7de6ff9840add6cca46
https://pubmed.ncbi.nlm.nih.gov/15728569
https://pubmed.ncbi.nlm.nih.gov/15728569
Publikováno v:
Investigative Opthalmology & Visual Science. 46:1092
PURPOSE. Previous work from the authors’ laboratory has shown that Hsp27 is specifically upregulated after retinal ischemic preconditioning (IPC), and this upregulation acts as a key cytoprotective factor in preventing retinal ischemic damage. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d7635542380f23e515ac5506d585dd
https://doi.org/10.1167/iovs.04-0043
https://doi.org/10.1167/iovs.04-0043
Autor:
Bryce A. Harrison, N. Andrew Whitlock, Michael V. Voronkov, Zheng Y. Almstead, Kun-jian Gu, Ross Mabon, Michael Gardyan, Brian D. Hamman, Jason Allen, Suma Gopinathan, Beth McKnight, Mike Crist, Yulian Zhang, Ying Liu, Lawrence F. Courtney, Billie Key, Julia Zhou, Nita Patel, Phil W. Yates, Qingyun Liu
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 21, p6515-6518, 4p
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