Zobrazeno 1 - 10
of 42
pro vyhledávání: '"N. André Sasaki"'
Publikováno v:
Pharmaceuticals, Vol 12, Iss 4, p 162 (2019)
There is an urgent need to propose effective treatments for Alzheimer’s disease (AD). Although the origin of the disease is poorly understood, several therapeutic options have been proposed. The new therapeutic approaches targeting biometal-mediate
Externí odkaz:
https://doaj.org/article/5348536f07954cd78c2b0de9cd104866
Autor:
N André Sasaki, Pascal Sonnet
Publikováno v:
Future medicinal chemistry. 13(24)
Instead of a conventional ‘one-drug-one-target approach’, this article presents a novel multi-target approach with a concept of trapping simultaneously as many detrimental factors as possible involved in the progression of Parkinson's disease. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d87c392e1ef1cdf5609823b41bce068
https://pubmed.ncbi.nlm.nih.gov/34634921
https://pubmed.ncbi.nlm.nih.gov/34634921
Publikováno v:
Pharmaceuticals
Volume 12
Issue 4
Pharmaceuticals, Vol 12, Iss 4, p 162 (2019)
Volume 12
Issue 4
Pharmaceuticals, Vol 12, Iss 4, p 162 (2019)
There is an urgent need to propose effective treatments for Alzheimer&rsquo
s disease (AD). Although the origin of the disease is poorly understood, several therapeutic options have been proposed. The new therapeutic approaches targeting biometa
s disease (AD). Although the origin of the disease is poorly understood, several therapeutic options have been proposed. The new therapeutic approaches targeting biometa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd94707f26e5cd9474547df87d7b57c1
Publikováno v:
Proceedings of 4th International Electronic Conference on Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e0dc8bb8adf9b93dafde1b8a419125
https://doi.org/10.3390/ecmc-4-05622
https://doi.org/10.3390/ecmc-4-05622
Publikováno v:
Proceedings of 3rd International Electronic Conference on Medicinal Chemistry.
Reactive carbonyl species (RCS) such as methylglyoxal (MGO) or malondialdehyde (MDA) are endogenously formed during the sugar glycoxidation and lipid peroxidation of polyunsaturated fatty acids induced by oxidative stress exacerbation. Their condensa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b8343e2462a24c1925ffa164beb2081
https://doi.org/10.3390/ecmc-3-04655
https://doi.org/10.3390/ecmc-3-04655
Publikováno v:
European journal of medicinal chemistry. 122
An important part of pathogenesis of Alzheimer's disease (AD) is attributed to the contribution of AGE (Advanced Glycation Endproducts) and ALE (Advanced Lipid peroxidation Endproducts). In order to attenuate the progression of AD, we designed a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de0cf31fc65328e84366052d0efe5d7
https://pubmed.ncbi.nlm.nih.gov/27451257
https://pubmed.ncbi.nlm.nih.gov/27451257
Publikováno v:
International Journal of Peptide and Protein Research. 27:366-372
An optically active, alkynyl analogue of norleucine (Nle), L-2-amino-4-hexynoic acid (Aha), was substituted for Met in the solution synthesis of the Boc-protected C-terminal heptapeptide analogue of substance P. Treatment of the resulting alkynyl pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b2b9e87d64838aabb42b7b7af86f8ef
https://doi.org/10.1111/j.1399-3011.1986.tb01029.x
https://doi.org/10.1111/j.1399-3011.1986.tb01029.x
Publikováno v:
International Journal of Peptide and Protein Research. 27:360-365
A synthesis is described of optically pure L-2-amino-4-hexynoic acid and its derivatives, which can serve as potentially useful precursors for the preparation of highly tritium labeled norleucine-containing peptides, as well as other side-chain modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef1994be800747a0cec71ca2e7588748
https://doi.org/10.1111/j.1399-3011.1986.tb01028.x
https://doi.org/10.1111/j.1399-3011.1986.tb01028.x
Publikováno v:
Tetrahedron. 63:2084-2092
Convergent syntheses of N-functionalized (3S,4S)-3-amino-4-vinyl-piperidin-2-one 10, trans-3-substituted proline 18 and (3S)-3-amino-piperidin-2-one 28 are developed. By incorporating these building blocks to an appropriate position, conformationally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb259e236c8855c53ec4252970eb53be
https://doi.org/10.1016/j.tet.2006.12.020
https://doi.org/10.1016/j.tet.2006.12.020
Autor:
Rajesh Dave, N. André Sasaki
Publikováno v:
Tetrahedron: Asymmetry
Tetrahedron: Asymmetry, Elsevier, 2006, 17(3), pp.388-401. ⟨10.1016/j.tetasy.2005.12.027⟩
Tetrahedron: Asymmetry, Elsevier, 2006, 17(3), pp.388-401. ⟨10.1016/j.tetasy.2005.12.027⟩
A broad variety of chiral C/N-functionalized morpholine alcohols sharing a common structural motif in the 3-(hydroxymethyl)morpholine 6 were prepared from enantiomerically pure serine for the purpose of studying their catalytic ligand properties. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f740daaf165481ef85145b4040ef5105
https://doi.org/10.1016/j.tetasy.2005.12.027
https://doi.org/10.1016/j.tetasy.2005.12.027