Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response

Autor: Kosala N. Amarasinghe, Diana Pelizzari-Raymundo, Antonio Carlesso, Eric Chevet, Leif A. Eriksson, Sayyed Jalil Mahdizadeh

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1584-1592 (2022)

The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activa

Externí odkaz: https://doaj.org/article/9c0a764ffe7b4efaad7c3bc6b85214d1

A curious case of Lactococcus garvieae bacteremia associated with adenocarcinoma

Autor: Sam N. Amarasinghe, Andee L. Fontenot, Ammar Husan, Muhammad W. Khan

Publikováno v: IDCases, Vol 29, Iss , Pp e01557- (2022)

Lactococcus garvieae is a pathogen typically acquired from the consumption of raw seafood or unpasteurized dairy products. Here, we present the unique case of a middle-aged gentleman who presented with back pain, originally thought to be muscle spasm

Externí odkaz: https://doaj.org/article/2b6b7df466064d1d82f2d728fa2a89b7

Resolving ice cloud optical thickness biases between CALIOP and MODIS using infrared retrievals

Autor: R. E. Holz, S. Platnick, K. Meyer, M. Vaughan, A. Heidinger, P. Yang, G. Wind, S. Dutcher, S. Ackerman, N. Amarasinghe, F. Nagle, C. Wang

Publikováno v: Atmospheric Chemistry and Physics, Vol 16, Pp 5075-5090 (2016)

Despite its importance as one of the key radiative properties that determines the impact of upper tropospheric clouds on the radiation balance, ice cloud optical thickness (IOT) has proven to be one of the more challenging properties to retrieve f

Externí odkaz: https://doaj.org/article/d3f119ebca9743d9abd9d564bd79a377

Soil-Gas Diffusivity-Based Characterization of Variably Saturated Agricultural Topsoils

Autor: A. M. S. N. Abeysinghe, M. M. T. Lakshani, U. D. H. N. Amarasinghe, Yuan Li, T. K. K. Chamindu Deepagoda, Wei Fu, Jun Fan, Ting Yang, Xiaoyi Ma, Tim Clough, Bo Elberling, Kathleen Smits

Publikováno v: Water; Volume 14; Issue 18; Pages: 2900
Abeysinghe, A M S N, Lakshani, M M T, Amarasinghe, U D H N, Li, Y, Deepagoda, T K K C, Fu, W, Fan, J, Yang, T, Ma, X, Clough, T, Elberling, B & Smits, K 2022, ' Soil-Gas Diffusivity-Based Characterization of Variably Saturated Agricultural Topsoils ', Water, vol. 14, no. 18, 2900 . https://doi.org/10.3390/w14182900

Soil-gas diffusivity and its variation with soil moisture plays a fundamental role in diffusion-controlled migration of climate-impact gases from different terrestrial agroecosystems including cultivated soils and managed pasture systems. The wide co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4265af47fb009d552c934f52f31f35f8

Virtual Screening Expands the Non-Natural Amino Acid Palette for Peptide Optimization

Autor: Kosala N. Amarasinghe, Leonardo De Maria, Christian Tyrchan, Leif A. Eriksson, Jens Sadowski, Dušan Petrović

Publikováno v: Journal of chemical information and modeling. 62(12)

Peptides are an important modality in drug discovery. While current peptide optimization focuses predominantly on the small number of natural and commercially available non-natural amino acids, the chemical spaces available for small molecule drug di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b77b75577684db94eb0b2b9c4c58ad2
https://pubmed.ncbi.nlm.nih.gov/35699524