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Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Autor: R Morawetz, K Black, N. A. Vick, Michael B. Sisti, Henry Brem, P Muller, Steven Brem, Peter C. Burger, S.C Schold, G Mohr, Michael D. Walker, Robert G. Selker, Steven Piantadosi

Publikováno v: The Lancet. 345:1008-1012

Chemotherapy for brain tumours has been limited because of difficulty in achieving adequate exposure to the tumour without systemic toxicity. We have developed a method for local sustained release of chemotherapeutic agents by their incorporation int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75368d4847c6f66a1316fb0b5d045443
https://doi.org/10.1016/s0140-6736(95)90755-6

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Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results

Autor: M T, Brown, R E, Coleman, A H, Friedman, H S, Friedman, R E, McLendon, R, Reiman, G J, Felsberg, R D, Tien, S H, Bigner, M R, Zalutsky, X G, Zhao, C J, Wikstrand, C N, Pegram, J E, Herndon, N A, Vick, N, Paleologos, R K, Fredericks, S C, Schold, D D, Bigner

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(6)

We aimed to determine the maximum tolerated dose (MTD) of 131I-labeled 81C6 in patients with leptomeningeal neoplasms or brain tumor resection cavities with subarachnoid communication and to identify any objective responses. 81C6 is a murine IgG mono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dead9f10aa76533772ffff9bf7faf1cc
https://pubmed.ncbi.nlm.nih.gov/9816257

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Spatial distribution of proliferating cells in avian sarcoma virus-induced gliomas

Autor: D R, Groothuis, J F, Pasternak, J M, Fischer, D D, Bigner, N A, Vick

Publikováno v: Cancer research. 43(2)

We studied the regional distribution of proliferating tumor cells in five avian sarcoma virus-induced gliomas. The labeling index and spatial distribution of [3H]thymidine (dThd)-labeled tumor cells were determined in serial sections of each tumor wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45213d5b5bf962b12fb9b3748efcc73c
https://pubmed.ncbi.nlm.nih.gov/6293696

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Reoperation for malignant astrocytoma

Autor: Ciric Is, N. A. Vick, Cozzens Jw, Eller Tw, A. Walsh

Publikováno v: Neurology. 39(3)

We evaluated 15 consecutive patients with malignant astrocytomas who were reoperated for functional status and survival. Their Karnovsky Performance Status (KPS) was not changed by surgery. None suffered perioperative death, wound infection, or compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489cacf28783aac56e4861f218fba778
https://pubmed.ncbi.nlm.nih.gov/2538776

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Regional measurements of blood flow in experimental RG-2 rat gliomas

Autor: D R, Groothuis, J F, Pasternak, J M, Fischer, R G, Blasberg, D D, Bigner, N A, Vick

Publikováno v: Cancer research. 43(7)

Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::418e7f81759448193b1c47e5f395b770
https://pubmed.ncbi.nlm.nih.gov/6850640

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