Zobrazeno 1 - 10
of 17
pro vyhledávání: '"N. A. Rohloff"'
Autor:
N. D. Staite, Sharon K. Shields, Megan Murphy, Robert J. Smith, Louise A. Galinet, Colin J. Dunn, Danielle G. Aspar, Karen A. Richard, N. A. Rohloff, Richard A. Nugent, Stephen T. Schlachter
Publikováno v:
Journal of Medicinal Chemistry. 36:134-139
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-1 in ether at 22 degrees C yield pyrazoline bisphosphonate tetraethyl esters 8a-1 in moderate to good yield. These compounds were evaluated in animal models of arthritis: rat adju
Autor:
C J, Dunn, L A, Galinet, H, Wu, R A, Nugent, S T, Schlachter, N D, Staite, D G, Aspar, G A, Elliott, N A, Essani, N A, Rohloff
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(3)
Diphosphonates (DP) are synthetic pyrophosphates with a P-C-P backbone and are predominantly used for the treatment of bone diseases. Several DP have also been shown to exert significant antiarthritic effects in the rat adjuvant-induced polyarthritis
Autor:
Robert J. Smith, James M. Justen, N. A. Rohloff, Marshall N. Brunden, Jia En Chin, Patricia L. Ruppel, Laurel M. Sam
Publikováno v:
Arthritis and rheumatism. 34(6)
Recombinant human interleukin-1 alpha (IL-1 alpha) induced a time-dependent (0-72 hours) and concentration-dependent (0.01-10 ng/ml) production of metalloproteinases (collagenase, gelatinase, stromelysin) and prostaglandin E2 (PGE2) in rabbit articul
Publikováno v:
Agents and Actions. 8:497-503
A simple laboratory test for the examination of topically-active steroids and non-steroids is described. The method(s) involves the application of 0.05 ml of 5% croton oil in ethanol or 0.1% H2SO4∶5% croton oil in ethanol to ears of rats. Irritants
Publikováno v:
Agents and Actions. 9:257-264
While some salicylates (salicyclic acid and salicylaldehyde, especially) are as potent as aspirin as acute, orally-active anti-flammatory drugs in the rat, they are either inactive or far less potent as PG synthesis inhibitors when added directly to
Publikováno v:
Clinical Immunology and Immunopathology. 26:24-34
A reversed passive Arthus reaction was elicited in the rat pleural cavity. The kinetics of this inflammatory response indicate that exudate volume (cells and fluid) reaches a maximum level approximately 2 to 4 hr postantibody challenge. The neutrophi
Autor:
James C. Cornette, N. A. Rohloff, Laurel M. Sam, James M. Justen, Robert J. Smith, Martin R. Deibel
Publikováno v:
Inflammation. 13:367-382
Recombinant human interleukin-1 alpha (rhIL-1 alpha) and recombinant human interleukin 1 beta (rhIL-1 beta) stimulated the time- and concentration-dependent release of glycosaminoglycan (GAG) from bovine nasal cartilage explants. Maximum GAG release
Autor:
N. A. Rohloff, Glenn Em
Publikováno v:
Experimental Biology and Medicine. 139:290-294
Summary and ConclusionsPGE1 and PGE2 produce antiarthritic and acute antiinflammatory effects when given at high dosages to rats. PGA2 and PGF2a are inactive in these tests. All of the prostaglandi...
Publikováno v:
Experimental Biology and Medicine. 138:244-248
Summary and DiscussionU-29,409 (2,3-dihydro- (1-naphthyl)-4-(1H)-quinazolinone), a male antispermatogenic drug, exerts anti-arthritic effects in rats similar to those elicited by Cytoxan. However, it is less effective than the latter. Laboratory scre
Publikováno v:
Agents and actions. 7(2)
The predominant white cell-type in circulating blood of normal rats is the lymphocyte. Granulocytes increase in the circulating blood of adjuvant-inoculated rats; lymphocytes remain the same or increase slightly. Some drugs, like Cytosar® (cytarabin