Zobrazeno 1 - 10 of 101 pro vyhledávání: '"N., Wirtz"'
1
Akademický článek
The antimicrobial fibupeptide lugdunin forms water-filled channel structures in lipid membranes
Autor: Dominik Ruppelt, Marius F. W. Trollmann, Taulant Dema, Sebastian N. Wirtz, Hendrik Flegel, Sophia Mönnikes, Stephanie Grond, Rainer A. Böckmann, Claudia Steinem
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Recently, a novel cyclo-heptapeptide composed of alternating d,l-amino acids and a unique thiazolidine heterocycle, called lugdunin, was discovered, which is produced by the nasal and skin commensal Staphylococcus lugdunensis. Lugdunin displ
Externí odkaz: https://doaj.org/article/38880531d1434ebb8518ed3032bab98c
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3
Distinct Lugdunins from a New Efficient Synthesis and Broad Exploitation of Its MRSA-Antimicrobial Structure
Autor: Stephanie Grond, Nadine A. Schilling, Bernhard Krismer, Julian S. Saur, Sebastian N. Wirtz, Andreas Peschel
Publikováno v: Journal of medicinal chemistry. 64(7)
A new solid-phase peptide synthesis and bioprofiling of the antimicrobial activity of lugdunin, a fibupeptide, enable a comprehensive structure–activity relationship (SAR) study (MRSA Staphylococcu...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d1b2eeff6ce615d532771b97262d0d
https://pubmed.ncbi.nlm.nih.gov/33779184
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4
Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis
Autor: Sebastian N. Wirtz, Martin C. Konnerth, Julian S. Saur, Simon Heilbronner, Bernhard Krismer, Alexander Zipperer, Andreas Peschel, Sophia Krauss, Stephanie Grond, Benjamin O. Torres Salazar
Publikováno v: Antimicrobial Agents and Chemotherapy
Lugdunin is the first reported nonribosomally synthesized antibiotic from human microbiomes. Its production by the commensal Staphylococcus lugdunensis eliminates the pathogen Staphylococcus aureus from human nasal microbiomes. The cycloheptapeptide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87908d91bd5c2c1cea1ed4896519fd33
https://doi.org/10.1128/aac.01734-20
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5
Akademický článek
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6
Akademický článek
Fluorine-Substitution in Cholesteryl Ester Transfer Protein Inhibitors (CETPInhibitors) – Biology, Chemistry, SAR, and Properties
Autor: Holger Paulsena, Siegfried Zaiss, Delf Schmidt, Hilmar Bischoff, Klaus-Dieter Bremm, Paul Naab, Michael Lögers, Stephan N. Wirtz, Jürgen Stoltefuss, Gunter Schmidt, Arndt Brandes, Carsten Schmeck, Stefan Antons
Publikováno v: CHIMIA, Vol 58, Iss 3 (2004)
The inhibition of the cholesteryl ester transfer protein (CETP) provides a method for the elevation of the high density lipoprotein cholesterol (HDL-C) level, i.e. the 'good' cholesterol. The expected anti-atherogenic effect of this approach is inde
Externí odkaz: https://doaj.org/article/ecc93d90677b4787979a5008cafe3ab9
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7
Akademický článek
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8
Metal Complexes (M = Zn, Sn, and Pb) of 2-Phosphinobenzenethiolates: Insights into Ligand Folding and Hemilability
Autor: Richard A. Kemp, Christopher A. Larsen, Benjamin W. Stein, Rory Waterman, Melissa N. Wirtz, William E. Geiger, Brian Barry
Publikováno v: Inorganic Chemistry. 52:9875-9884
The divalent metal complexes M(II){(SC6H4-2-PR2)-κ(2)S,P}2 (3-7, and 9-11) (M = Zn, Sn, or Pb; R = (i)Pr, (t)Bu, or Ph), the Sn(IV) complexes Sn{(SC6H4-2-PR2)-κ(2)-S,P}Ph2Cl (12 and 13) (R = (i)Pr and (t)Bu), and the ionic Sn(IV) complexes [Sn{(SC6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208b6b972da16a24ea46b5829ee82a1
https://doi.org/10.1021/ic400990n
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9
Facilitated carbon dioxide reduction using a Zn(II) complex
Autor: Christopher A. Larsen, Richard A. Kemp, William E. Geiger, Brian Barry, Melissa N. Wirtz, Elizabeth S. Donovan
Publikováno v: Chemical communications (Cambridge, England). 52(8)
Two new Zn(II) complexes have been prepared and evaluated for their capacity to activate and reduce CO2. The electrochemical properties of dichlorobis[diphenyl-(2-pyridyl)phosphine-κ(1)-N]zinc(II) [corrected]. and dichloro[diphenyl-(2-pyridyl)phosph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c935c3d9f6966c758d0224a74148e23
https://pubmed.ncbi.nlm.nih.gov/26812211
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10
Acute metabolic, hormonal, and psychological responses to strength training with superimposed EMS at the beginning and the end of a 6 week training period
Autor: N, Wirtz, P, Wahl, H, Kleinöder, K, Wechsler, S, Achtzehn, J, Mester
Publikováno v: Journal of Musculoskeletal & Neuronal Interactions
Objectives: The aim was to determine metabolic and hormonal responses to strength training with or without superimposed electromyostimulation (EMS) at the beginning and the end of a 6 week training period. Methods: 20 strength trained subjects were r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c20bfb2f62062726e02cc03d39fc42d4
https://pubmed.ncbi.nlm.nih.gov/26636278
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