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Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?

Autor: Luís Pereira de Almeida, Rebekah Koppenol, Clévio Nóbrega, Adriana Marcelo, Carlos A. Matos

Publikováno v: Cell Death & Disease
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)

Stress granules (SGs) are membraneless cell compartments formed in response to different stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other proteins coalesce together. SGs assembly is crucial for cell survival,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d507d0a6b2ef228b18efcf97ab3c49a
http://europepmc.org/articles/PMC8187637

Selection and characterization of llama single domain antibodies against N-terminal huntingtin

Autor: Willeke M. C. van Roon-Mom, Gert-Jan B. van Ommen, Barry A. Pepers, Theo Verrips, Silvère M. van der Maarel, Menno H. Schut, Johan T. den Dunnen, Mohamed el Khatabi, Rinse Klooster

Publikováno v: Neurological Sciences, 36(3), 429-434
Neurological Sciences

Huntington disease is caused by expansion of a CAG repeat in the huntingtin gene that is translated into an elongated polyglutamine stretch within the N-terminal domain of the huntingtin protein. The mutation is thought to introduce a gain-of-toxic f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0a352cb98e8df7d42653d961711a1f
https://doi.org/10.1007/s10072-014-1971-6

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

Autor: Amritpal Mudher, T. Burbidge-King, J.L. Marsh, Leslie M. Thompson, Andreas Wyttenbach, D. Soh, Christopher Sinadinos

Publikováno v: Neurobiology of Disease, Vol 34, Iss 2, Pp 389-395 (2009)
Sinadinos, C; Burbidge-King, T; Soh, D; Thompson, LM; Marsh, JL; Wyttenbach, A; et al.(2009). Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons. Neurobiology of Disease, 34(2), 389-395. doi: 10.1016/j.nbd.2009.02.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/30g9v0dv

Huntington's Disease is a neurodegenerative condition caused by a polyglutamine expansion in the huntingtin (Htt) protein, which aggregates and also causes neuronal dysfunction. Pathogenic N-terminal htt fragments perturb axonal transport in vitro. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae09498de4caf9d5ee07db92c77ba70
http://www.sciencedirect.com/science/article/pii/S0969996109000424

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